BPN 14770 CAS Nr .: 1606974-33-7

Khoom npe: BPN14770
Lub ntsiab lus: Zatolmilast; Zatolmilast, Phosphodiesterase (PDE), BPN-14770, Inhibitor, BPN 14770, inhibit; Zatolmilast (BPN14770); Zatolmilast (BPN14770), S6844
CAS Nr .: 1606974-33-7
EINECS NO.:/
Cov mis mos molecular: C21H15ClF3NO2
Purity & Qib: 99%; Qib tshuaj
Cim: Dawb hmoov
Cov qauv dawb: Muaj
Tshuag: Hauv Tshuag
Warehouse: USA/EU/AU Warehouse
MOQ & Pob: 1g; Pob raws li xav tau
Shipping: Kev nyab xeeb thiab xa khoom sai
Lub Sijhawm Lead: 5-10 hnub
Khw & Txee lub neej: Txias & qhuav qhov chaw; 24 hli

Xa kev nug

Ces

Hauj lwm lawm

BPN 14770 CAS Nr .: 1606974-33-7yog ib qho kev xaiv allosteric inhibitor ntawm phosphodiesterase 4D (PDE4D), nrog IC50 qhov tseem ceeb ntawm 7.8 nM rau PDE4D7 thiab 7.4 nM rau PDE4D3. Zatolmilast yog ib tus neeg sib tw tshawb nrhiav nyob rau theem tseem ceeb hauv kev kho mob thoob ntiaj teb, tshwj xeeb tsim los daws Fragile X syndrome, qhov tsis tshua muaj kab mob neurodevelopmental.

Raws li lub ntiaj teb thawj qhov kev xaiv zoo tshaj plaws allosteric modulator tsom rau PDE4D, nws txoj haujlwm tseem ceeb nyob hauv kev tswj hwm lub cev ntawm intracellular cyclic adenosine monophosphate (cAMP) txoj kev taw qhia. Los ntawm tshwj xeeb inhibiting ob isoforms PDE4D3 thiab PDE4D7, nws zoo nce intracellular cAMP concentration, yog li activating downstream CREB signaling txoj kev, txhawb lub synthesis thiab tso tawm ntawm lub hlwb- muab tau neurotrophic yam (BDNF), kho puas synaptic kev twb kev txuas nyob rau hauv lub synaptic theem, thiab enh lub hlwb. kev txawj ntse, lus, thiab neurological functions. Fragile X syndrome, uas yog qhov ua rau muaj kev tsis taus ntawm kev txawj ntse thiab kev puas siab puas ntsws spectrum, tau ntev tsis muaj cov phiaj xwm cuam tshuam. Zatolmilast, nrog nws cov txheej txheem tshwj xeeb ntawm kev nqis tes ua, yuav tsum ua kom tiav qhov sib txawv no.

Kev sim	Specifications	Cov txiaj ntsig
Qhov tshwm sim	Dawb hmoov	Ua raws
Specification	99%	Ua raws
tsw	Yam ntxwv	Ua raws
Particle loj	100% dhau 80 mesh	Ua raws
Cov hlau hnyav
Total Heavy metals	Tsawg dua lossis sib npaug li 10ppm	Ua raws
Microbial
Tag nrho microbacterial suav	Tsawg dua lossis sib npaug li 1000cfu / g	Ua raws
Poov & Mould	Tsawg dua lossis sib npaug li 100cfu / g	Ua raws
Escherichia Coli muaj nyob	Tsis zoo	Ua raws
Salmonella	Tsis zoo	Ua raws
Staphylococcus	Tsis zoo	Ua raws
Xaus	Ua raws li kev lag luam specification

Acidity/Balance: Cov molecule muaj ib pawg carboxyl (-COOH), faib nws li cov kua qaub tsis muaj zog.

pKa: Tus nqi tseeb tsis qhia tawm (kwv yees ntau yam 4.5–5.5)

Lipid-dej faib coefficient (logP): Kev sim tus nqi tsis qhia tawm (kev kwv yees kwv yees 4.0–5.0, siab lipophilic)

Stability: Khoom: ruaj khov thaum tiv thaiv los ntawm lub teeb, qhuav, thiab nyob rau hauv qhov kub thiab txias.

Kev daws: Yooj yim hydrolyzed hauv aqueous tov; kuj ruaj khov nyob rau hauv DMSO tov.

Sensitive rau lub teeb, tshav kub, thiab oxidants.

Polarity: Nruab nrab polarity.

Zatolmilast yog ib qho kev xaiv phosphodiesterase 4D (PDE4D) allosteric inhibitor.

Core Function: Tshwj xeeb inhibits PDE4D3 thiab PDE4D7 isoforms (IC50 qhov tseem ceeb ntawm 7.4 nM thiab 7.8 nM, raws li), tiv thaiv kev degradation ntawm tus xa xov thib ob cyclic adenosine monophosphate (cAMP).

Cov teebmeem hauv qab: Ua kom lub hlwb cAMP nce siab, ua kom lub cev cAMP cov lus teb -binding protein (CREB) phosphorylation, txhawb lub hlwb- muab tau los ntawm neurotrophic factor (BDNF) synthesis, thaum kawg txhim kho synaptic plasticity thiab txhim kho kev txawj ntse.

Peb ua raws li lub hauv paus ntsiab lus ntawm "tus neeg siv khoom ua ntej, kev ua siab ncaj ua ntej", thiab ib txwm muab cov neeg siv khoom nrog cov khoom zoo thiab muaj txiaj ntsig zoo thiab - cov kev pabcuam zoo. Xaiv kev ncaj ncees. Xaiv lub neej noj qab nyob zoo!

Nrog rau peb cov kev siv zog tas mus li thiab kev pabcuam zoo, peb cia siab tias yuav tsim kom muaj kev koom tes ntev ntev thiab kev txhim kho nrog cov neeg siv khoom thiab muab sijhawm rau peb. Peb ntseeg tias peb yuav ua rau koj txaus siab rau thawj -chav kawm zoo, nyab xeeb thiab xa khoom sai thiab txaus siab tom qab- kev muag khoom.

BPN14770 CAS 1606974-33-7

Tsheb thauj mus los	Shipping txoj kev	Cargo hnyav xav tau	Qhov zoo
3-7 hnub	DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, UPS, USPS, FedEx, TNT, EMS	Haum rau qis dua 50kg. International qhov rooj rau qhov rooj nthuav qhia	Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, thiab cov neeg muas zaub nyob rau hauv cov teb chaws Europe thiab America muaj peev xwm txaus siab rau xa cov khoom ncaj qha los ntawm ob qhov chaw.
7-15 hnub	Los ntawm Cua	Haum rau ntau tshaj 50kg. ceev thiab pheej yig dua rau kev txiav txim loj
15-60 hnub	Los ntawm Hiav Txwv	Haum rau ntau tshaj 500kg. Kev xa khoom pheej yig tshaj plaws

Cov kev ntsuam xyuas cuam tshuam qhia tau tias nws ua tau zoo tag nrho, nrog rau qhov tsis tshua muaj tshwm sim ntawm qhov tsis zoo tshwm sim thiab kev nyab xeeb zoo tag nrho.

Nws yuav tsum tau muab cia rau hauv qhov chaw txias, qhuav, lub teeb - tiv thaiv, thiab kaw ib puag ncig. Rau lub sijhawm ntev - khaws cia, nws raug nquahu kom tswj hwm qhov chaw qis dua -20 degrees Celsius thiab tsis txhob raug kub hnyiab thiab lub teeb muaj zog.

Koj tuaj yeem tiv tauj tus email chaw nyob hauv qab no:sales4@faithfulbio.com

Tsis lees paub: Tag nrho cov khoom lag luam (tsis yog- cov khoom raug cai) cov duab raug coj los ua zoo, tab sis vim yog lub zog ntawm lub teeb (lub sijhawm sib txawv, lub teeb tom qab sib txawv), cov txheej txheem tua, cov khoom siv sib txawv thiab lwm yam, tej zaum yuav muaj qee qhov sib txawv ntawm daim duab thiab cov xim tiag tiag, cov xim ntawm cov khoom, thov coj cov nyhuv tiag tiag, xim txawv ntawm cov khoom tsis yog qhov teeb meem zoo.

Nco tseg: Nco ntsoov sab laj nrog tus kws kho mob uas tsim nyog ua ntej noj cov tshuaj tshiab. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho lossis tiv thaiv txhua yam kab mob.Thaum lub sijhawm yuav khoom, tus neeg yuav khoom thoob ntiaj teb pom zoo xav tias muaj kev pheej hmoo ntawm txhua yam khoom tuaj txog. Peb tsis tuaj yeem hloov cov khoom ploj lossis raug kaw. Ua ntej xa cov khoom, koj yuav tsum paub meej tias koj pom zoo rau cov nqe lus no.Qhov no tsuas yog kev pom zoo koob tshuaj raws li peb tus kheej kev paub thiab cov ntaub ntawv pov thawj. Peb pom zoo kom koj ua koj tus kheej kev tshawb fawb ua ntej siv cov khoom no.

Nqe lus:Cov khoom no tsuas yog siv rau kev tshawb fawb tshawb fawb, thiab qhov tshwm sim ntawm lwm yam kev siv tsis muaj lub luag haujlwm.

Cim npe nrov: bpn14770 cas 1606974-33-7, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, kev muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua nyob rau hauv Suav teb

Tug:Dabogratinib CAS 2800223-30-5

Tom ntej:XEN1101 CAS 1009344-33-5

Xa kev nug

Koj Tseem Yuav Zoo Li