Cabozantinib Powder yog dab tsi?
Cabozantinib yog qhov tshiab molecular tsom cov yeeb tshuaj tsim los ntawm exelixis biopharmaceutical tuam txhab hauv Tebchaws Meskas. Thaum Lub Kaum Ib Hlis 29, 2012, Asmeskas Cov Ntaub Ntawv Noj thiab Tshuaj Siv (FDA) Pom zoo cabrozantinib rau kev kho mob ntawm UntreStally hauv zos lossis Metastatic Median Cancer Cancer.Cabozantinib Hmoovyog nyob rau hauv ib chav kawm ntawm cov tshuaj hu ua kinase inhibitors.Nws ua haujlwm los ntawm kev thaiv qhov kev txiav txim ntawm cov protein ntau txawv txav uas ua rau cov qog nqaij hlav qog noj ntshav ntau. Qhov no yuav pab qeeb lossis nres kev sib kis ntawm cov qog nqaij hlav cancer.
 |
Khoom npe |
Cabozantinib |
|
CAS |
849217-68-1 |
|
|
Cov mis mos molecular |
C28H24FN3O5 |
|
|
Molecular hnyav |
501.51 |
|
|
EINECS Number |
692-846-8 |
|
|
Kev cia khoom |
-20} degree lub freezer |
|
|
Qhov tshwm sim |
Cov hmoov dawb |
|
|
melting point |
212-215 degree | |
|
Solubility |
Dissolved nyob rau hauv dimethyl sulfoxide |
Puas yog Cabozantinib hmoov muaj kev ua haujlwm biological?
Cabozantinib Hmoov (XL184, BMS -907351}) yog cov tshuaj tiv thaiv zoo nrog IC5 {4 4}} ntawm 0.035nm hauv cov xovtooj ntawm tes. Nws kuj ua tau zoo c-tau ntsib, ret, khoom, flt {{{, thiab axnm, 4nm, 12nm, 12.3nm, thiab 7nm, feem. Cabozantinib tuaj yeem ntxias Puma nyob hauv cov mob plab hnyuv los ntawm AKT / GSK {{25} b ntawm txoj kev taug.
Cabozantinib Powder ua haujlwm li cas?
Cabozantinib hmoovua haujlwm nyob rau hauv 2 txoj kev:
txwv cov qog nqaij hlav los ntawm kev loj hlob ntawm lawv cov hlab ntsha uas muab zaub mov thiab oxygen kom loj hlob
thaiv cov lus uas qhia cov qog nqaij hlav cancer kom loj hlob
Hauv vitro biochemical thiab / lossis cytological tsom xam pom tias cabozantinib inhibits RET, human hepatocyte growth factor receptor (MET), vascular endothelial growth factor 1 (VEGFR-1), VEGFR-2, VEGFR{{3} }, qia cell loj hlob yam receptor (KIT), tyrosine kinase receptor (TRKB), FMS zoo li phau ntawv tshuaj tyrosine kinase 3 (FLT-3), AXL, thiab tib neeg txoj kev loj hlob zoo li domain tyrosine kinase 2 (HGF-2). Tsis muaj immunoglobulin zoo li thiab EGF zoo li domains2 (TIE-2) Kev ua haujlwm tyrosine kinase ntawm cov kinase receptors ua lub luag haujlwm tseem ceeb hauv cov txheej txheem loj hlob ntawm ob lub hlwb thiab qog hlwb. Kev qhia txawv txav ntawm cov receptors no ua lub luag haujlwm tseem ceeb hauv qhov tshwm sim thiab kev loj hlob ntawm ntau cov qog, nrog rau inhibiting qog cell apoptosis, koom nrog cov txheej txheem pathological xws li qog angiogenesis thiab ntxeem tau. Cabozantinib tawm dag zog los tiv thaiv qog nqaij hlav los ntawm inhibiting cov haujlwm ntawm kinases tau hais tseg, tua cov qog hlwb, txo cov metastasis, thiab inhibiting qog angiogenesis.
Yog tias koj muaj qhov kev xav tau qub, Nyem email:sales1@faithfulbio.com
Khoom Qhia Txog Khoom
| Kev ntsuam xyuas | Lub hom phiaj | Kev tshwm sim |
|
Kev tshwm sim |
Cov hmoov dawb |
Ntuas |
| Kev txheeb xyuas | H-NMR | Ntuas |
| Tus neeg Iypurity | Tsawg dua los yog sib npaug rau 0.5% | 0.23% |
| Tag nrho impurity | Tsawg dua lossis sib npaug rau 1.0% | 0.33% |
| Purity | 98.0%-100% | 99.5% |
Xaus:Raws li specification thiab tsim nyog.
Puas yog Cabozantinib Powder muaj qhov cuam tshuam tsis zoo?
In clinical trials, common adverse reactions caused by cabozantinib include diarrhea, stomatitis, Palmar plantar erythropathy syndrome (PPES), weight loss, loss of appetite, nausea, fatigue, oral pain, color changes, taste disorders, high blood pressure, abdominal pain, and constipation. The most common laboratory abnormalities (>25%) yog qhov nce nyob rau hauv aspartate aminottransferase thiab alanotransferase, kev txo qis hauv cov lymphocemia, neutropocytop, hypophosphatemia, thiab hyperbilirubinemia. Tom qab thawj koob ntawm cabozantinib kho, 57% ntawm cov neeg mob pom tias muaj kev nce siab hauv cov neeg mob qog ua ke (cov nyiaj tau los ntawm cov neeg mob tau txais qhov chaw.
Dab tsi yog cov kev tshawb fawb txog Cabozantinib?
Hauv kev tshawb fawb vitro
XL184 yog ib qho me me molecule inhibitor ntawm ntau yam receptor tyrosine kinases, tshwj xeeb tshaj yog inhibiting c-Met thiab VEGFR2. XL-184 kuj ua tau zoo ntawm Ret, Kit, FLT1, FLT3, FLT4, Tie2, IC50 qhov tseem ceeb rau AXL yog 4nM, 4.6nM, 12nM, 11.3nM, 6nM, 14.3nM, thiab 7nM , raws. XL184 tsis muaj zog inhibits RON thiab PDGFR - nrog IC50 qhov tseem ceeb ntawm 124nM thiab 234nM, raws li, thaum nws yuav luag tsis muaj kev cuam tshuam ntawm FGFR1 nrog IC50 tus nqi ntawm 5.294 μ M. Kev kho mob ntawm MPNST hlwb nrog XL184 ntawm qis concentrations (0.{{30). }}.5 μ M) cuam tshuam loj heev thiab inducible Met phosphorylation thiab downstream signaling, as well as HGF induced MPNST cell migration and invasion.Cabozantinib hmoovua rau cytokine stimulated human umbilical vein endothelial cells (HUVECs) thiab inhibits Met thiab VEGFR2 phosphorylation. Txawm hais tias XL184 tsis tuaj yeem cuam tshuam kev loj hlob ntawm MPNST hlwb ntawm qhov siab ntawm 0.1 μ M, nws tuaj yeem cuam tshuam kev loj hlob ntawm MPNST hlwb. Txawm li cas los xij, ntawm qhov concentration ntawm 5-10 μ M, nws tuaj yeem cuam tshuam kev loj hlob ntawm MPNST hlwb.
Hauv Vivo Tshawb Fawb
XL184 kho RIP-Tag2 nas nqa cov kab mob pancreatic islet cell ntawm ib koob ntawm 30mg / kg cuam tshuam 83% ntawm cov hlab ntsha qog, txo cov pericytes thiab lub tsho hauv qab hauv qab ntawm lub cev, ua rau muaj kev cuam tshuam ntawm intratumoral hypoxia thiab nthuav cov qog cell apoptosis, thiab qeeb. regrowth tom qab discontinuation. Piv nrog rau XL999, Cabozantinib Tseem ceeb inhibited vegfr ntau dua c-ntsib, ua rau muaj cov hlab ntshav ntawm cov hlab ntshav, qhia txog lwm cov hlab ntshav XL184 tseem txo cov ntxeem tau thiab metastasis ntawm thawj hlav. Kev kho mob XL184 kev kho mob scid nas ntawm 30mm / kg ib hnub twg tshem tawm txoj kev loj hlob thiab metastasis ntawm tib neeg mpnst transplanted hlav. Cabozantinib tuaj yeem ua rau muaj kev loj hlob ntawm tus mob cancom mis thiab mob ntsws ua rau mob qog nqaij daim tawv, txo cov kev loj hlob ntawm cov qog thiab cov hlwb endothelial, thiab txhawb nqa tus apoptosis. XL184 kho cov nas nqa mda-mb {8}} Cov hlav} kev zas xim ntawm cov tshuaj 100mg / kg, ntsig txog kev nkag mus rau cov qog tsis tu ncua.
Yuav ua li cas thiab qhov twg yuav Cabozantinib Powder wholesale?
Peb muaj 8 xyoo dhau los ntawm kev muag cov tshuaj tshawb fawb raug cai thiab muaj lub koob npe zoo, ua rau peb muaj kev ntseeg siab.
Peb paub tseeb tias qhov zoo ntawm peb cov khoom los ntawm kev sim ua haujlwm ywj pheej, thiab txhua tus neeg siv khoom yog peb VIP.
Xa koj qhov kev nug kom paub ntau ntxiv, Nyem Email:sales1@faithfulbio.comTam sim no.
Muaj ntau txoj kev xa khoom rau koj xaiv
|
Tsheb Thauj Mus Los |
Shipping txoj kev |
Cargo Qhov hnyav |
Qhov zoo |
|
3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau hauv qab 50kg. |
Peb muaj cov chaw khaws khoom hauv Tebchaws Yelemees thiab California, Asmeskas, |
|
7-15 hnub |
Los ntawm huab cua |
Haum rau ntau tshaj 50kg. |
|
|
15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Kev tsis lees paub: Cov ntawv hauv lub vev xaib no yog siv rau kev tshawb fawb thiab kev sib pauv kev kawm. Thov ua tib zoo saib qhov tseeb ntawm lawv cov kev xav thiab cov ntsiab lus. Yog tias koj pom muaj kev ua txhaum cai. Thov hu rau tus thawj tswj hwm tam sim ntawd. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm cov ntaub ntawv thiab cov kev pabcuam muab rau hauv lub vev xaib no.
Tsab ntawv: Cov khoom no yog siv rau kev tshawb fawb nkaus xwb thiab tsis yog npaj rau kev kuaj mob, kev kho mob, kev tiv thaiv kab mob, thiab lwm yam.
Xa koj qhov kev nug kom paub meej ntxiv, nyem email:sales1@faithfulbio.comTam sim no.
Cim npe nrov: Cabozantinib hmoov cas {849217-68-1, cov chaw muag khoom, chaw tsim khoom, kev lag luam, cov khoom siv dawb, khoom siv raw, ua hauv Phiaj suav