Acyclovir hmoov CAS 59277-89-3

Acyclovir, ib qho hluavtaws purine nucleoside antiviral, yog ib qho ntawm feem ntau siv tshuaj tiv thaiv kab mob. Nws yog tsuas yog siv rau ntau yam kab mob tshwm sim los ntawm tus kab mob herpes simplex, thiab tuaj yeem siv rau thawj lossis rov ua dua ntawm daim tawv nqaij, mucous membrane, kab mob sab nraud ntawm qhov chaw mos thiab kab mob HSV hauv cov neeg mob tsis muaj zog tiv thaiv kab mob. Raws li thawj qhov kev xaiv rau kev kho mob ntawm HSV encephalitis, nws yog qhov zoo tshaj rau adenosine arabine hauv kev txo qis kev mob thiab kev tuag. Nws kuj tseem tuaj yeem siv rau tus kab mob herpes zoster, Epstein-Barr tus kab mob, thiab cov neeg uas muaj kev tiv thaiv kab mob ua rau mob khaub thuas thiab lwm yam kab mob. Topically siv rau ntawm daim tawv nqaij xwb, daim tawv nqaij absorption yog tsawg. Hloov mus rau hauv triphosphate tebchaw hauv vivo, nws cuam tshuam nrog cov kab mob DNA polymerase, inhibits kab mob DNA replication thiab plays lub luag hauj lwm tiv thaiv kab mob, uas muaj zog rau cov kab mob. Acyclovir hloov los ntawm tus kab mob thymidine kinase rau acyclovir monophosphate thiab tom qab ntawd los ntawm tus tswv tsev cell kinase rau ACyclovir triphosphate (ACV-TP, tseem hu ua acyclovir GTP). ACV-TP yog ib qho zoo heev inhibitor ntawm tus kab mob DNA replication. ACV-TP sib tw inhibits thiab inactivates kab mob DNA polymerase. Cov monophosphates kuj tau muab tso rau hauv cov kab mob DNA, uas ua rau kev txiav tawm ntawm cov protein synthesis saw.

Cov khoom no yog purine nucleoside derivative, muaj cov nyhuv inhibitory ntawm DNA synthesis, thiab nws cov kev tiv thaiv kab mob herpesvirus yog 160 npaug zog dua li ntawm adenosine arabine. Nws yog siv rau kev kho mob yooj yim herpes virus encephalitis, herpes virus keratitis thiab lwm yam kab mob ntawm qhov chaw mos, AIDS varicella zoster kab mob thiab cytomegalovirus kab mob, kab mob siab B thiab lwm yam.