Khoom Taw Qhia
Atorvastatin hmoov CAS 134523-00-5yog HMG-CoA reductase inhibitor nyob rau hauv daim ntawv ntawm calcium ntsev. Nws tau xub sau npe hauv Tebchaws Yelemees thiab UK thaum Lub Ob Hlis 1997 thiab thawj zaug pom zoo rau kev lag luam hauv UK thaum lub Plaub Hlis 1997. Cov txheeb ze molecular loj yog 1155.36. Atorvastatin yog ib qho tshuaj statin feem ntau siv hauv kev kho mob. Ntxiv nrog rau kev kho mob hypercholesterolemia, nws muaj kev tiv thaiv zoo ntawm kev kub siab, kab mob plawv thiab kab mob cerebrovascular.
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| Atorvastatin hmoov Daim duab | Atorvastatin hmoov MF |
Khoom siv
Atorvastatin hmoov CAS 134523-00-5yog statin feem ntau siv hauv kev kho mob. Ntxiv nrog rau kev kho mob hypercholesterolemia, nws muaj kev tiv thaiv zoo ntawm kev kub siab, kab mob plawv thiab kab mob cerebrovascular. Los ntawm txoj kev xav ntawm cov kab mob plawv, atorvastatin tuaj yeem tiv thaiv kev ua haujlwm endothelial, ncua atherosclerosis, tiv thaiv cov kab mob hauv nruab nrog cev thiab txhim kho kev soj ntsuam hauv cov neeg mob atherosclerosis; atorvastatin tuaj yeem txo CRP thiab txo cov tsos mob hauv cov neeg mob uas mob plawv; atorvastatin tuaj yeem txo CD40 thiab CD40L qhia hauv cov neeg mob ntshav siab, ua kom cov nyhuv hypotensive thiab txhim kho lub cev kev nplij siab ntawm cov neeg mob. Los ntawm qhov kev xav ntawm kab mob cerebrovascular, atorvastatin tuaj yeem txo qis-CRP ntau ntau thiab txhim kho kev puas hlwb hauv cov neeg mob uas mob cerebral infarction; atorvastatin tuaj yeem cuam tshuam qhov kev qhia ntawm cysteine proteases 3 thiab 5 thiab txo cov tsos mob vasospasm hauv cov neeg mob uas muaj ntshav qab zib subarachnoid.
Lub synthesis ntawm benzyl ether pyrrole intermediate, nrog rau cov atorvastatin precursor, tau ua los ntawm kev kho mob ntawm 1,4-diketone intermediates 4 thiab 10, raws li, nrog rau cov lag luam muaj thawj amine 5 nyob rau hauv ib tug pivalic acid. -catalyzed Paal-Knorr condensation cov tshuaj tiv thaiv (Scheme (Scheme1.1). Lub 1,4-diketone intermediates 4 thiab 10 tau ua ke los ntawm Stetter cov tshuaj tiv thaiv .
Hauv cov ntsiab lus, cov , -unsaturated ketone 1 tau ua ke nrog benzaldehydes 2 thiab 9, feem, nyob rau hauv lub xub ntiag ntawm triethylamine thiab thiazolium bromide catalyst 3 kom them tau qhov sib thooj 1, 4-diketone intermediates 4 thiab 10, raws li. Atorvastatin tau txais los ntawm nws cov neeg ua ntej tom qab ze li ntawm qhov kev tshem tawm ntawm ketal-ester tiv thaiv pab pawg hauv cov kab sib txuas nrog cov kab ke hydrochloric acid thiab sodium hydroxide kho.
Khoom Specification
| Yam khoom | Specification | Kev tshwm sim | |
| Qhov tshwm sim | Dawb rau lub teeb daj hmoov | Ua raws | |
| Poob rau ziab | Tsawg dua lossis sib npaug rau 2.0% | 0.19% | |
| Cov hlau hnyav | Tsawg dua los yog sib npaug li 10 ppm | <10ppm | |
| Dej | Tsawg dua lossis sib npaug rau 1.0% | 0.20% | |
| Sulfated tshauv | Tsawg dua lossis sib npaug rau {{0}}.5%, txiav txim siab ntawm 1.0 g. | 0.01% | |
| Cov khoom muaj feem xyuam | Unspecified impurities: rau txhua impurity | Tsawg dua lossis sib npaug rau 0.10% | <0.10% |
| Tag nrho impurity | Tsawg dua los yog sib npaug rau 0.5% | 0.19% | |
| Purity | Ntau dua lossis sib npaug rau 99.0% | 99.54% | |
| Assay | 99. | 99.86% | |
| Microbiological Analysis | |||
| Tag nrho cov phaj suav | Tsawg dua lossis sib npaug li 1000cfu / g | Ua raws | |
| Poov thiab Pwm | Tsawg dua lossis sib npaug li 100cfu / g | Ua raws | |
| E. Coli. | Tsis muaj | Tsis zoo | |
| Salmonella | Tsis muaj | Tsis zoo | |
| S.aureus | Tsis muaj | Tsis zoo | |
| Xaus | Cov khoom saum toj no ntawm cov khoom ua raws li cov qauv kev lag luam | ||
Yuav Ua Li Cas Kom Tau Txais Cov QauvAtorvastatin hmoov?
Txais tos xa ib qho kev nug rausunny@faithfulbio.comtxhua lub sijhawm rau tus qauv dawb yog tias koj xav tau APIAtorvastatin hmoov.
Qhov zoo tshaj plaws Atorvastatin hmoov Chaw tsim tshuaj paus thiab tsum
Faithfulbio muaj kev paub dhau los hauv kev xa tawm cov ntaub ntawv raw thiab tau tsim kev sib raug zoo thiab kev koom tes ntev nrog peb cov neeg siv khoom. Peb ib txwm muab cov khoom zoo thiab kev pabcuam ua ntej. Yog tias koj muaj cov khoom siv raw khoom xav tau, thov hu rau peb. Peb tuaj yeem lees paub qhov kev txiav txim nrog koj raws li koj qhov yuav khoom ntau. Peb kuj txhawb peb txoj kev koom tes thawj zaug pib los ntawm cov qauv. Tsis tas li ntawd, peb txoj kev thauj mus los sai thiab nyab xeeb kuj ua rau koj tshem tawm cov teeb meem ntawm kev lis kev cai.
Peb muaj kev ntseeg siab ntawm peb cov khoom zoo, tab sis yog tias muaj teeb meem tom qab muag, peb yuav teb sai li sai tau thiab daws lawv nrog koj txoj hauv kev zoo tshaj plaws.
Vim Li Cas Xaiv FaithfulbioAtorvastatin hmoov?
Faithfulbio tshwj xeeb hauvAtorvastatin hmoovrau ntau xyoo, peb muab cov khoom ntawm tus nqi sib tw, thiab peb cov khoom yog qhov zoo tshaj plaws, vim tias peb nruj heev hauv cov khoom tsim thiab kev sim, thiab muaj kev ua tiav thiab paub tab. Tsis tas li ntawd, peb cov neeg ua haujlwm Cov lus hais rau cov khoom muaj kev sib tw heev.
Muaj ntau txoj kev xa khoom rau koj xaiv
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Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
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3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
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7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
ua siab zoo ceeb toom:SivAtorvastatin hmoovrau kev tshawb fawb nkaus xwb. Txhua lub tebchaw muaj kev pheej hmoo. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv. Tsis tas li ntawd, cov lus piav qhia saum toj no ntawm qhov sib xyaw yog los ntawm cov ntaub ntawv online. Yog tias muaj kev ua txhaum cai, thov hu rau peb kom tshem tawm.
Yuav Ua Li Cas Atorvastatin hmoov?
Cia li xa email rausunny@faithfulbio.com, lossis xa koj qhov yuav tsum tau ua hauv daim ntawv hauv qab, peb muaj kev pabcuam txhua lub sijhawm!
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