Bortezomib hmoov, ib qho tshuaj rau kev kho mob qog nqaij hlav hauv cov kab mob hematopoietic, yog dawb lossis ze li ntawm cov hmoov dawb crystalline, uas yog soluble hauv dimethyl sulfoxide thiab ethanol, tab sis insoluble hauv dej. Melting point: 122-124 degree, molecular mis: C19H25BN4O4, molecular hnyav: 384.23700, ntom: 1.214.
Bortezomib tuaj yeem ua ke nrog melphalan thiab prednisone rau kev kho mob ntawm cov neeg mob uas tsis tau kho yav dhau los uas muaj ntau yam myeloma uas tsis haum rau kev siv tshuaj tua kab mob siab thiab kev tiv thaiv pob txha pob txha; Nws kuj tseem tuaj yeem siv rau kev kho mob ntawm cov neeg mob uas rov muaj dua lossis refractory mantle cell lymphoma, uas tau txais tsawg kawg ib qho kev kho mob ua ntej siv Bortezomib.
Bortezomib yog dab tsi?
Bortezomib hmoovyog ib qho tshuaj tiv thaiv qog noj ntshav tshiab tsim los ntawm American Millennium Pharmaceutical Company. Nws yog 26S proteasome inhibitor, uas thaiv kev degradation ntawm ntau cov proteins uas tswj apoptosis thiab teeb liab hloov hauv cov hlwb, thiab ua rau cov qog hlwb tuag.
Bortezomib yog ib qho tshuaj tiv thaiv kab mob cancer thiab thawj cov tshuaj tiv thaiv proteasome rau tib neeg. Proteasome yog lub cell complex uas decomposes protein. Hauv qee cov qog nqaij hlav, cov protein, uas feem ntau tua cov qog nqaij hlav cancer, tawg sai heev. Bortezomib cuam tshuam cov txheej txheem no thiab cia cov proteins no tua cov qog nqaij hlav cancer. Nws tau pom zoo rau kev kho mob ntawm ntau yam myeloma thiab mantle cell lymphoma hauv Tebchaws Meskas thiab Europe. Hauv ntau tus neeg mob myeloma, cov lus teb kho mob tau ua tiav hauv cov neeg mob uas muaj lwm cov kab mob refractory lossis cov kab mob loj zuj zus.
Bortezomib yog thawj hluavtaws proteasome inhibitor nyob rau hauv lub ntiaj teb no, uas muaj peev xwm ncua, nres thiab kho qhov deterioration ntawm ntau yam myeloma thiab mantle cell lymphoma. Nws yog ib qho tshuaj tiv thaiv kab mob tshiab rau kev kho mob. Qhov inhibition ntawm proteasomes yog thim rov qab, yog li tswj tau thiab kwv yees kev nyab xeeb tshuaj yog nws qhov zoo tshaj plaws.
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Cov duab tiag tiag ntawm Bortezomib nyoos hmoov | Bortezomib Structure Diagram |
Bortezomib ua haujlwm li cas?
Bortezomib yog ib qho kev thim rov qab inhibitor ntawm chymotrypsin-zoo li kev ua ntawm 26S proteasome nyob rau hauv mammalian hlwb. 26S proteasome yog ib tug loj protein complex, uas yuav degrade ubiquitinated proteins. Ubiquitin proteasome channel plays lub luag haujlwm tseem ceeb hauv kev tswj hwm cov ntsiab lus ntawm cov proteins tshwj xeeb hauv cov hlwb kom muaj kev ruaj ntseg ntawm ib puag ncig intracellular. Protein hydrolysis yuav cuam tshuam rau ntau theem teeb liab series hauv hlwb, thiab qhov kev puas tsuaj rau ib puag ncig intracellular yuav ua rau cell tuag. Qhov inhibition ntawm 26S proteasome tuaj yeem tiv thaiv hydrolysis ntawm cov proteins tshwj xeeb. Kev sim hauv vitro tau ua pov thawj tias bortezomib yog cytotoxic rau ntau hom qog noj ntshav. Cov qauv qog ua ntej hauv vivo kuaj tau ua pov thawj tias bortezomib tuaj yeem ncua kev loj hlob ntawm cov qog nrog rau ntau yam myeloma.
Kuv yuav tsum xyuam xim rau dab tsi thaum siv Bortezomib?
Nws yuav tsum tau siv nyob rau hauv kev saib xyuas ntawm tus kws kho mob uas muaj kev paub txog kev siv tshuaj antineoplastic, thiab tag nrho cov ntshav cell suav (CBC) yuav tsum tau saib xyuas ntau zaus thaum siv nws. Nws yog ib qho tshuaj tiv thaiv qog, yog li nws yuav tsum tau ua tib zoo npaj thiab ua haujlwm nrog cov hnab looj tes tiv thaiv kev sib cuag ntawm daim tawv nqaij.
Cov yam ntxwv kev nyab xeeb ntawm Bortezomib monotherapy yog zoo ib yam li cov kev pom nyob rau hauv kev sib xyaw ntawm melphalan thiab prednisone.
Yuav xaiv cov khoom siv li cas
Nilotinib | 641571-10-0 |
Toremifene Citrate | 89778-27-8 |
Sodium dichloroacetate hmoov | 2156-56-1 |
Ribonucleic acid | 63231-63-0 |
sorafenib tosylate | 475207-59-1 |
Vinblastine Sulfate / Vinblastine Sulphate | 143-67-9 |
vincristine | 57-22-7 |
Topotecan hydrochloride | 119413-54-6 |
Flutamide | 13311-84-7 |
Lomustine | 13010-47-4 |
Lenvatinib mesylate | 857890-39-2 |
Dasatinib | 302962-49-8 |
Oxaliplatin | 61825-94-3/63121-00-6 |
Sunitinib malate | 341031-54-7 |
Irinotecan | 97682-44-5 |
Irinotecan Hydrochloride | 100286-90-6 |
Lenalidomide | 191732-72-6 |
Doxorubicin hydrochloride | 25316-40-9 |
Pirfenidone | 53179-13-8 |
cov tshuaj bicalutamide | 90357-06-5 |
Cyclophosphamide | 50-18-0 |
Temozolomide | 85622-93-1 |
Methotrexate / Trexall | 59-05-2 |
Anastrozole / Anastrazole / Arimidex | 120511-73-1 |
Tamoxifen | 10540-29-1 |
Tamoxifen citrate | 54965-24-1 |
Trilostane | 13647-35-3 |
Exemestane | 107868-30-4 |
Ruxolitinib | 941678-49-5 |
Ruxolitinib phosphate | 1092939-17-7 |
Sirolimus / Rapamycin | 53123-88-9 |
Indole 3 Carbinol / | 700-06-1 |
3,3'-Diindolylmethane hmoov | 1968-05-4 |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Koj tuaj yeem tiv tauj kuv ntawm WhatsApp:+86 13137770562
Muaj ntau hom kev xa khoom rau koj xaiv
Tsheb thauj mus los | Shipping txoj kev | Cargo hnyav xav tau | Qhov zoo |
3-7 hnub | DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, | Haum rau qis dua 50kg. | Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, lub teb chaws USA, |
7-15 hnub | Los ntawm Cua | Haum rau ntau tshaj 50kg. | |
15-60 hnub | Los ntawm Hiav Txwv | Haum rau ntau tshaj 500kg. |
Tsis lees paub: Cov ntawv luam tawm ntawm lub vev xaib no yog siv los txhawb kev sib pauv kev kawm thiab kev kawm, thiab tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov lim kom zoo. Yog tias koj ntseeg tias tsab xov xwm no ua txhaum, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.
Nco tseg: Cov tshuaj no yuav tsum tau siv rau kev tshawb fawb nkaus xwb. Cov lus thov no tsis tau raug soj ntsuam los ntawm Food and Drug Administration. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv lawv. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho lossis tiv thaiv kab mob.
Cim npe nrov: bortezomib hmoov cas 179324-69-7, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, muag