Khoom Taw Qhia
Celecoxib hmoovyog ib tiam tshiab ntawm non-steroidal anti-inflammatory analgesics. Nws inhibits zus tau tej cov prostaglandins los ntawm kev xaiv inhibiting cyclooxygenase-2 (COX-2), ua kom muaj kev tiv thaiv kab mob thiab tshuaj tua kab mob. Cov phenyl pawg ntawm celecoxib khi rau hydrophobic channel ntawm COX-2, thiab pawg hydrophilic sulfonamide tsim cov saw hydrogen nrog arginine ntawm txoj hauj lwm 513 thiab histidine ntawm txoj hauj lwm 90 hauv "sab hnab tshos" ntawm COX{{8 }}. Cov khoom no kuj zoo sib xws rau arginine ntawm txoj hauj lwm 120 ntawm COX-2, yog li inhibiting X-2 los ntawm kev hloov arachidonic acid rau hauv prostaglandins uas muaj teeb meem rau tib neeg lub cev. Vim muaj qhov sib txawv me me hauv cov qauv ntawm COX-1 thiab COX-2, cov tshuaj no tsis tuaj yeem nkag mus rau COX-1 molecule, thiab nws tsis tuaj yeem cuam tshuam kev hloov pauv ntawm arachidonic acid rau hauv prostaglandins los ntawm COX{ {15}}.
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| Celecoxib hmoov Daim duab | Celecoxib hmoov MF |
Khoom siv
Celecoxib hmoovNws muaj cov txiaj ntsig zoo los tiv thaiv kab mob thiab tshuaj tua kab mob, tiv thaiv kab mob plab, tswj lub raum cov ntshav khiav, thiab tswj cov platelet aggregation, thiab daws cov kab mob plab hnyuv ntawm cov NSAIDs uas nquag siv. Nws yog siv los kho mob caj dab thiab muaj cov tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob, thiab txo cov tsos mob thiab cov tsos mob ntawm osteoarthritis thiab mob caj dab rheumatoid.
Lub hom phiaj ntawm txoj kev tshawb no yog kev txheeb xyuas ntawm celecoxib los ntawm ntau txoj kev tshuaj ntsuam. Celecoxib tau txheeb xyuas los ntawm nws cov melting range, ultraviolet thiab infrared spectrophotometric, nyias txheej chromatography, thiab nuclear magnetic resonance, tag nrho cov ntawm lawv ua raws li cov txheej txheem ntawm cov nom lis dej num. Cov txheej txheem siv tau pom tias yog ceev, ua tau zoo, rov tsim dua thiab tsim nyog rau kev txheeb xyuas ntawm celecoxib.
Results: Faster dissolution rate was exhibited by SD containing 1:5 ratio of celecoxib: PVP K-30 prepared by coevaporation method. In vitro drug release of celecoxib, gels revealed that formulation with HPMC has higher drug release as compared to Carbopol. Conclusion: The increase in dissolution rate for SD is observed in the following order of PVP K-30>urea>mannitol>PEG 6000. CPD5 gel uas muaj SD CP5 thiab 20% DMSO tau pom qhov zoo tshaj plaws hauv vitro tso tawm 74.13% thaum kawg ntawm 6 h.
Khoom Specification
| Yam khoom | Specification | Kev tshwm sim |
| Qhov tshwm sim | Dawb mus rau dawb hmoov | Ua raws |
| Kev sib hloov tshwj xeeb[]D20 | {{0}}.5 degree ~ -86.0 degree | -84.7 degree |
| Lub Xeev Txoj Cai | NLT98.0% | 98.65% |
| Chloride | NMT 0.020% | NMT 0.020% |
| Ammonium | NMT 0.02% | NMT 0.02% |
| Sulfate | NMT 0.020% | NMT 0.020% |
| Hlau | NMT 10 ppm | NMT 10 ppm |
| Heavy Metals (Pb) | NMT 10 ppm | NMT 10 ppm |
| Arsenic | NMT 1 ppm | NMT 1 ppm |
| Lwm yam Amino Acids | Chromatographically tsis ntes tau | Ua raws |
| Poob rau ziab | NMT 0.30% | 0.20% |
| Residue ntawm Ignition | NMT0.10% | 0.05% |
| Assay | 99.0% ~101.0% | 99.50% |
| PH | 5.9~6.9 | 6.0 |
| Xaus | Ua raws li tus qauv kev lag luam | |
Yuav Ua Li Cas Kom Tau Txais Cov QauvCelecoxib hmoov?
Txais tos xa ib qho kev nug rausunny@faithfulbio.comtxhua lub sijhawm rau tus qauv dawb yog tias koj xav tau APICelecoxib hmoov.
Qhov zoo tshaj plaws Celecoxib hmoov Chaw tsim tshuaj paus thiab tsum
Faithfulbio muaj kev paub dhau los hauv kev xa tawm cov ntaub ntawv raw thiab tau tsim kev sib raug zoo thiab kev koom tes ntev nrog peb cov neeg siv khoom. Peb ib txwm muab cov khoom zoo thiab kev pabcuam ua ntej. Yog tias koj muaj cov khoom siv raw khoom xav tau, thov hu rau peb. Peb tuaj yeem lees paub qhov kev txiav txim nrog koj raws li koj qhov yuav khoom ntau. Peb kuj txhawb peb txoj kev koom tes thawj zaug pib los ntawm cov qauv. Tsis tas li ntawd, peb txoj kev thauj mus los sai thiab nyab xeeb kuj ua rau koj tshem tawm cov teeb meem ntawm kev lis kev cai.
Peb muaj kev ntseeg siab ntawm peb cov khoom zoo, tab sis yog tias muaj teeb meem tom qab muag, peb yuav teb sai li sai tau thiab daws lawv nrog koj txoj hauv kev zoo tshaj plaws.
Vim Li Cas Xaiv FaithfulbioCelecoxib hmoov?
Faithfulbio tshwj xeeb hauvCelecoxib hmoovrau ntau xyoo, peb muab cov khoom ntawm tus nqi sib tw, thiab peb cov khoom yog qhov zoo tshaj plaws, vim tias peb nruj heev hauv cov khoom tsim thiab kev sim, thiab muaj kev ua tiav thiab paub tab. Tsis tas li ntawd, peb cov neeg ua haujlwm Cov lus hais rau cov khoom muaj kev sib tw heev.
Muaj ntau txoj kev xa khoom rau koj xaiv
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Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
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3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
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7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
ua siab zoo ceeb toom:SivCelecoxib hmoovrau kev tshawb fawb nkaus xwb. Txhua lub tebchaw muaj kev pheej hmoo. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv. Tsis tas li ntawd, cov lus piav qhia saum toj no ntawm qhov sib xyaw yog los ntawm cov ntaub ntawv online. Yog tias muaj kev ua txhaum cai, thov hu rau peb kom tshem tawm.
Yuav Ua Li Cas Celecoxib hmoov?
Cia li xa email rausunny@faithfulbio.com, lossis xa koj qhov yuav tsum tau ua hauv daim ntawv hauv qab, peb muaj kev pabcuam txhua lub sijhawm!
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