Taw qhia ntawm Dapoxetine:
Dapoxetine hmoovyog dej-soluble dawb los yog dawb dawb hmoov. Nws yog ib hom tshiab ntawm 5-HT reuptake inhibitor. Nws cov qauv tshuaj zoo ib yam li cov tshuaj antidepressant fluoxetine. Nws tsuas yog 5-HT reuptake inhibitor uas tsis muaj halogen atoms. Lub hauv paus neurotransmitters 5-HT thiab dopamine thiab lawv cov receptors ua lub luag haujlwm tseem ceeb hauv kev tswj ejaculation. Dapoxetine tuaj yeem cuam tshuam 5-HT reuptake los ntawm inhibiting 5-HT transporters, nce 5-HT concentration hauv synaptic cleft, thiab qhib 5-HT2C thiab 5-HT1A receptors nyob rau hauv postsynaptic daim nyias nyias rau exert nws cov teebmeem. Piv nrog rau lwm yam 5-HT reuptake inhibitors, dapoxetine muaj qhov zoo ntawm kev ua tau zoo, luv luv ib nrab-lub neej, thiab tsawg dua kev phiv.
Dapoxetine yog dawb crystalline hmoov, tsw thiab qab zib, hygroscopic, soluble nyob rau hauv dej, thiab ruaj khov nyob rau hauv cov khoom, nrog ib tug melting point ntawm 175 ~ 177 degree.
| Khoom npe | Dapoxetine |
| CAS | 119356-77-3 |
| Cov mis mos molecular | C21H23 Nr |
| Molecular hnyav | 305.41 |
| EINECS Number | 1308068-626-2 |
| Kev cia khoom | -20 degree lub freezer |
| Melting point | 48 - 49 degree |
| Solubility | Soluble hauv chloroform (me ntsis), DMSO (me ntsis, rhuab) thiab methanol (me ntsis) |
| Qhov tshwm sim | Dawb rau lub teeb xim av hmoov |
| Boiling point | 454.4 ± 38. 0 degree (Predicted) |
| Qhov ntom | 1. 081 ± 0.06 g/cm3 |
Dapoxetine yog dab tsi?
Dab tsi yog pharmacological kev txiav txim ntawm Dapoxetine?
| Yam khoom | Specification | Cov txiaj ntsig |
| Kev piav qhia | Dawb los yog Lub teeb daj crystalline hmoov, tsw ntxhiab | Ua raws |
| Solubility | Yooj yim soluble hauv dej, unsoluble hauv ethanol | Ua raws |
| PH | 6.0~7.5 | 6.9 |
| Cov khoom muaj feem xyuam | Yooj yim impurity | 0.03% |
| Tag nrho lwm yam impurity | 0.10% | |
| Chloride | 0.05% | Ua raws |
| Ammonium | 0.05% | Ua raws |
| Fe | 0.01% | Ua raws |
| Poob rau ziab | Tsawg dua lossis sib npaug rau 1.0% | 0.32% |
| Cov hlau hnyav | 0.002% | Ua raws |
| Arsenid | 0.0001% | Ua raws |
| Cov kab mob endotoxins | 0.3EU/mg | Ua raws |
| Methanol | Tsawg dua lossis sib npaug rau 0.3% | 0.021% |
| Methylene dichloride | Tsawg dua lossis sib npaug rau 0.06% | 0.017% |
| Assay | 98.5~101.5% | 99.6% |
| Xaus: Ua raws li kev lag luam specification. | ||
Pharmacokinetics ntawm Dapoxetine
nqus
Kev noj zaub mov muaj roj tsawg tuaj yeem txo cov khoom Cmax los ntawm 10% thiab nce AUC (chaw nyob hauv qab nkhaus) los ntawm 12%, thiab tib lub sijhawm, nws tuaj yeem ncua sij hawm me ntsis ntawm cov khoom lub sijhawm ncov; Txawm li cas los xij, kev noj zaub mov muaj roj ntau yuav tsis cuam tshuam rau qib kev nqus. Cov kev hloov no tsis muaj qhov tseem ceeb hauv kev kho mob. Seb cov khoom no tuaj yeem noj nrog zaub mov lossis tsis tau.
Muab faib
Hauv vitro, ntau dua 99% ntawm cov khoom tuaj yeem ua ke nrog tib neeg cov ntshav ntshav protein. Cov protein binding tus nqi ntawm Desmethyldapoxetine, active metabolite, yog 98.5%.Dapoxetine hmoovtuaj yeem faib tau sai, nrog qhov nruab nrab ntawm qhov nruab nrab ntawm lub xeev faib ntim ntawm 162L L.
Metabolize
Cov kev tshawb fawb hauv vitro qhia tias Dapoxetine hmoov tuaj yeem raug tshem tawm los ntawm ntau lub tshuab enzyme hauv daim siab thiab lub raum, feem ntau yog CYP2D6, CYP3A4 thiab flavin monooxygenase 1 (FMO1).
Nws thiab N-oxide yog cov ntaub ntawv tseem ceeb hauv cov ntshav. Lwm cov metabolites suav nrog Desmethyldapoxetine, uas muaj cov haujlwm zoo ib yam li nws, thiab cov haujlwm ntawm bisdemethyldapoxetine yog li 50% ntawm nws. Xav txog qhov kev ua si thiab plasma dawb concentration, tsuas yog Desmethyldapoxetine tuaj yeem ua rau nws cov haujlwm hauv vivo.
Tshem tawm
Nws cov metabolites feem ntau yog tawm hauv cov zis nyob rau hauv daim ntawv ntawm conjugates. Tsis pom cov tshuaj thawj zaug hauv cov zis. Nws tuaj yeem raug tshem tawm sai, thiab cov pov thawj yog tias cov ntshav siab tsawg (tsawg dua 5% ntawm qhov siab tshaj plaws concentration) 24 teev tom qab kev tswj hwm. Ib nrab-lub neej ntawm nordapoxetine zoo ib yam li cov tshuaj qub.
HTML5 atlas of Dapoxetine
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1H NMR ntawm Dapoxetine
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13C NMR ntawm Dapoxetine
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Dapoxetine ua haujlwm li cas?
Cov txheej txheem ntawm dapoxetine yog xav tias muaj feem xyuam rau inhibition ntawm serotonin reuptake los ntawm neurons thiab tom qab txhim kho kev ua serotonin. Lub hauv paus ejaculatory paj hlwb yog tsim los ntawm tus txha caj qaum thiab lub paj hlwb cheeb tsam, tsim ib tug heev interconnected network. Raws li kev cuam tshuam ntawm qhov chaw mos thiab lub hlwb stimulation, lub paj hlwb sympathetic, parasympathetic paj hlwb, thiab somatic spinal qaum chaw koom tes los tswj cov xwm txheej physiological thaum lub sij hawm ejaculation. Kev sim ua pov thawj qhia tau tias serotonin ({0}}HT) tuaj yeem cuam tshuam ejaculation nyob rau hauv tag nrho cov descending hlwb txoj kev. Txog tam sim no, peb hom subtypes ntawm 5-HT receptor (5-HT(1A), 5-HT(1B), thiab 5-HT(2C)) tau kwv yees los kho cov kev cai ntawm 5-HT ntawm ejaculation.
Dab tsi yog cov tshuaj sib cuam tshuam ntawm Dapoxetine?
Zoo li tag nrho lwm cov khoom,dapoxetine hmoovtuaj yeem cuam tshuam nrog lwm yam tshuaj. Feem ntau, nws yuav tsum tsis txhob sib xyaw nrog cov tshuaj tiv thaiv kev ntxhov siab, cov ntshav thinners, los yog cov khoom siv kho mob raum lossis kab mob siab, thiab yuav tsum tsis txhob siv los ntawm cov neeg uas nquag ua kom lub cev qhuav dej ntau dhau.
Lwm cov tshuaj cuam tshuam nrog dapoxetine. Tias yog vim li cas koj yuav tsum qhia peb seb cov tshuaj noj dab tsi, tshuaj tom khw muag khoom, thiab cov tshuaj ua si uas koj noj, siv lawv zoo dua.
Thaum twg kuv yuav tsum tsis txhob siv dapoxetine?
rhiab heev
Yog tias koj ua xua rau dapoxetine, thov zam. Kev ua xua rau cov tshuaj no tsis tshua muaj. Txawm li cas los xij, yog tias koj pom cov tsos mob xws li pob khaus, khaus / o (tshwj xeeb tshaj yog ntsej muag / tus nplaig / caj pas), kiv taub hau, thiab ua tsis taus pa, thov mus nrhiav kev kho mob tam sim ntawd.
Lub plawv tsis muaj zog
Lub plawv tsis ua haujlwm yog ib yam kab mob uas lub plawv tsis tuaj yeem tso ntshav txaus rau tag nrho lub cev. Yog tias koj raug kev txom nyem los ntawm lub plawv tsis ua haujlwm, dapoxetine tsis pom zoo vim tias nws tuaj yeem ua rau muaj kev pheej hmoo ntawm kev puas tsuaj.
arrhythmia
Yog tias koj muaj arrhythmia, nws tsis pom zoo kom siv dapoxetine vim nws yuav ua rau muaj kev pheej hmoo ntawm kev puas tsuaj.
Kev puas siab puas ntsws Bipolar
Kev puas siab puas ntsws bipolar yog ib qho kev puas siab puas ntsws uas muaj kev hloov pauv loj heev, suav nrog kev mob siab ntsws (mob siab, ua siab ntev, kev zoo siab heev, thiab lwm yam) thiab kev nyuaj siab (kev nyuaj siab thiab kev tu siab). Yog tias koj muaj keeb kwm ntawm kev puas siab puas ntsws bipolar, dapoxetine tsis pom zoo vim nws yuav ua rau muaj kev pheej hmoo ntawm kev mob nkeeg.
Nruab nrab mus rau lub siab ua haujlwm hnyav
Yog tias koj muaj teeb meem mob siab rau mob siab, dapoxetine tsis pom zoo. Lub siab ua haujlwm tsis zoo tuaj yeem ua rau cov tshuaj nkag mus rau hauv cov ntshav, yog li ua rau muaj kev phom sij loj.
Yuav ua li cas thiab qhov twg yuav dapoxetine lag luam wholesale?
Koj tuaj yeem tso siab rau peb qhov kev txiav txim vim tias peb muaj cov ntaub ntawv zoo ntawm kev muag tshuaj raws cai.
Peb ua qhov kev kuaj xyuas ywj pheej ntawm txhua yam khoom thiab tom qab ntawd muag rau peb cov neeg siv khoom hwm.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Muaj ntau txoj kev xa khoom rau koj xaiv
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Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
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3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
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7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Tsis lees paub: Cov ntawv luam tawm ntawm lub xaib no yog siv los txhawb kev sib pauv kev kawm thiab kev kawm, thiab tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov lim kom zoo. Yog tias koj ntseeg tias tsab xov xwm no ua txhaum, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.
Nco tseg: Cov tshuaj no yuav tsum tau siv rau kev tshawb fawb nkaus xwb. Cov lus thov no tsis tau raug soj ntsuam los ntawm Food and Drug Administration. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv lawv. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho, lossis tiv thaiv txhua yam kab mob.
Cim npe nrov: dapoxetine hmoov cas 119356-77-3, Suav teb, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, kev muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua nyob rau hauv Tuam Tshoj