Indomethacin yog dab tsi?
Indomethacin yog ib qho zoo thiab tsis xaiv inhibitor ntawm COX1 thiab COX2. Hauv CHO hlwb, IC50 qhov tseem ceeb ntawm tib neeg COX-1 thiab COX-2 yog 18 nM thiab 26 nM, raws li.
Indomethacin yog ib qho tshuaj uas tsis yog-steroidal anti-inflammatory tshuaj (NSAIDs), uas muaj cov tshuaj tiv thaiv kab mob, antipyretic thiab analgesic. Nws ua lub luag haujlwm tiv thaiv kab mob los ntawm inhibiting cyclooxygenase thiab txo qis prostaglandin synthesis, thiab cov nyhuv antipyretic cuam tshuam rau inhibiting prostaglandin synthesis hauv inferior colliculus.
Indomethacin hmoovyog dawb los yog yellowish crystalline hmoov. Melting point yog 158-162 degree . Soluble nyob rau hauv acetone, me ntsis soluble nyob rau hauv methanol, ethanol, chloroform thiab ether, me ntsis soluble nyob rau hauv toluene thiab yuav luag insoluble nyob rau hauv dej. Tasteless, yuav luag odorless.
| Khoom npe | Indomethacin |
| CAS | 53-86-1 |
| Cov mis mos molecular | C19H16ClNO4 |
| Molecular hnyav | 357.79 |
| EINECS Number | 200-186-5 |
| Kev cia khoom | Khw hauv RT |
| Melting point | 158-162 degree |
| Solubility | Ethanol: 50 mg / mL, ntshiab, yellowish ntsuab. |
| Qhov tshwm sim | Dawb mus rau dawb hmoov |
| Boiling point | 499.4 ± 45. 0 degree (Predicted) |
| Qhov ntom | 1.2135 (zeeg) |
Yuav ua li cas yog lub pharmacological mechanism ntawm Indomethacin?
Indomethacin hmoovyog ib qho tshuaj indoleacetic acid nonsteroidal anti-inflammatory siv tshuaj, uas muaj anti-inflammatory, antipyretic thiab analgesic teebmeem. Nws cov txheej txheem yog txo cov synthesis ntawm prostaglandin los ntawm inhibiting cyclooxygenase. Nres qhov tsim ntawm nociceptive paj impulses nyob rau hauv cov ntaub so ntswg inflammatory thiab inhibit inflammatory tshua, nrog rau inhibiting lub chemotaxis ntawm cov qe ntshav dawb thiab tso tawm ntawm lysosomal enzymes. Raws li cov nyhuv antipyretic, vim tias nws ua haujlwm ntawm qhov chaw thermoregulatory ntawm hypothalamus, nws tuaj yeem ua rau cov hlab ntsha peripheral dilate thiab tawm hws, thiab ua rau kom kub dissipation. Cov nyhuv antipyretic hauv nruab nrab kuj tseem tuaj yeem cuam tshuam nrog inhibition ntawm prostaglandin synthesis hauv hypothalamus.
Khoom Specification
| Yam khoom | Specification | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb hmoov | Paub meej |
| tsw & saj | Yam ntxwv | Paub meej |
| Poob rau ziab | Tsawg dua lossis sib npaug rau 8.0% | 2.80% |
| Kev ntsuam xyuas (HPLC) | 10.0% min | 10.20% |
| Tshauv | Tsawg dua lossis sib npaug rau 1.0% | 0.35% |
| Hnyav Hlau | Tsawg dua los yog sib npaug li 10 ppm | Paub meej |
| Raws li | Tsawg dua lossis sib npaug rau 1.0ppm | Paub meej |
| Pb | Tsawg dua lossis sib npaug rau 1.0ppm | Paub meej |
| Cd | Tsawg dua lossis sib npaug rau 1.0ppm | Paub meej |
| Hg | Tsawg dua lossis sib npaug rau 0.1ppm | Paub meej |
| Tag nrho cov phaj suav | Tsawg dua lossis sib npaug li 1000 cfu / g | lees paub |
| Yeast & Pwm | Tsawg dua lossis sib npaug li 100 cfu / g | lees paub |
| E. Coli | Tsis zoo | Tsis zoo |
| Salmonella | Tsis zoo | Tsis zoo |
| Staphylococcus aureus | Tsis zoo | Tsis zoo |
| Xaus | Ua raws li USP Standard. | |
Cov teb twg yog indomethacin siv rau?
1.Indomethacin hmoovyog ib yam tshuaj uas tsis yog tshuaj hormonal los tiv thaiv inflammatory thiab analgesic.
2. Nws muaj anti-inflammatory thiab antipyretic teebmeem, thiab yog tsuas yog siv rau rheumatic mob caj dab, ankylosing spondylitis, osteoarthritis, thiab lwm yam., uas yog tsis yooj yim rau zam salicylic acid cov khoom los yog tsis pom tseeb curative nyhuv.
3. Cyclooxygenase (COX) inhibitor, uas selectively inhibits COX-1; Thaiv lub biosynthesis ntawm prostatic qaum.
HTML5 atlas of Indomethacin
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Puas yog indomethacin ib qho tshuaj tiv thaiv kab mob analgesic?
Indomethacin hmoovyog ib yam uas tsis yog-corticosteroid anti-inflammatory, antipyretic thiab analgesic tshuaj uas muaj zog. Los ntawm inhibiting cyclooxygenase, nws tuaj yeem txo cov synthesis ntawm prostaglandin (PG), nres qhov tsim ntawm qhov mob paj hlwb impulse nyob rau hauv cov ntaub so ntswg inflammatory thiab inhibit inflammatory cov tshuaj, yog li ua antipyretic, analgesic thiab anti-inflammatory teebmeem. Indomethacin muaj zog tiv thaiv kab mob thiab tshuaj tua kab mob, thiab nws cov tshuaj tiv thaiv kab mob yog 84 npaug zog dua li ntawm phenylbutazone thiab muaj zog dua li ntawm hydrocortisone. Kev siv ua ke nrog glucocorticoid, tshuaj aspirin thiab phenylbutazone tuaj yeem txo lawv cov koob tshuaj, tshuaj lom thiab kev phiv thiab txhim kho cov nyhuv curative. Qhov thib ob, cov nyhuv antipyretic yog 10 npaug ntawm aminopyrine; Cov nyhuv analgesic tsis muaj zog, thiab nws tsuas muaj cov nyhuv analgesic ntawm qhov mob, tab sis nws cov nyhuv ntawm qhov mob inflammatory zoo dua li ntawm phenylbutazone, analgin thiab salicylic acid.
Dab tsi yog qhov txawv ntawm ibuprofen thiab indomethacin?
Ibuprofen thiab indomethacin yog cov tshuaj antipyretic, analgesic thiab anti-inflammatory tshuaj, thiab ntau qhov sib txawv yog raws li nram no:
1. Cov qauv sib txawv:Indomethacin hmoovbelongs rau cov tshuaj indole, thaum ibuprofen belongs rau aryl propionic acid tshuaj;
2. Lub hom phiaj ntawm kev ua yeeb tshuaj yog txawv: lawv txhua tus muaj cov tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob hauv cov tshuaj pharmacological, tab sis lawv lub hom phiaj yog txawv. Indomethacin yog ib qho ntawm cov muaj zog tshaj inhibitors ntawm prostaglandin synthase, uas muaj pom tseeb los tiv thaiv inflammatory thiab anti-rheumatic los, thiab kuj muaj ib tug zoo analgesic nyhuv ntawm inflammatory mob. Nws cov teebmeem antipyretic thiab analgesic zoo ib yam li cov tshuaj aspirin. Ibuprofen kuj muaj zog antipyretic, analgesic, anti-inflammatory thiab anti-rheumatic teebmeem, tab sis nws cov nyhuv muaj feem xyuam rau ntau npaum. Hauv ntau npaum li cas, nws tuaj yeem kho mob rheumatoid mob caj dab, mob caj dab rheumatic thiab osteoarthritis. Kev kho mob niaj hnub tuaj yeem txo qhov mob me thiab nruab nrab thiab tseem tuaj yeem siv rau kev kho mob antipyretic, tab sis kev saib xyuas yuav tsum tau them rau qhov kev xaiv ntawm ntau npaum li cas rau qhov mob thiab kev kho mob antipyretic.
Dab tsi yog kev ceev faj rau kev siv Indomethacin?
(1) Indomethacin hmoovthiab cov tshuaj aspirin hmoov yog cross-allergic. Cov neeg mob hawb pob los ntawm kev tsis haum tshuaj aspirin tuaj yeem ua rau bronchospasm thaum siv nws. Cov neeg uas tsis haum rau lwm cov tshuaj uas tsis yog-steroidal anti-inflammatory thiab analgesic tshuaj kuj yuav ua xua rau cov khoom no.
(2) Cov khoom no yuav tsum tau siv nrog ceev faj rau cov neeg mob uas mob plawv tsis txaus thiab kub siab.
(3) Vim tias indomethacin tuaj yeem cuam tshuam cov platelet aggregation, nws tuaj yeem ua rau lub sijhawm los ntshav ntev, thiab cov nyhuv no tuaj yeem kav ntev li 1 hnub tom qab tso tseg.
Yuav ua li cas thiab qhov twg yuav Indomethacin Powder wholesale?
Koj tuaj yeem tso siab rau peb qhov kev txiav txim vim tias peb muaj cov ntaub ntawv zoo ntawm kev muag tshuaj raws cai.
Peb ua qhov kev kuaj xyuas ywj pheej ntawm txhua yam khoom thiab tom qab ntawd muag rau peb cov neeg siv khoom hwm.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Muaj ntau txoj kev xa khoom rau koj xaiv
|
Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
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3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
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7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Tsis lees paub: Cov ntawv luam tawm ntawm lub xaib no yog siv los txhawb kev sib pauv kev kawm thiab kev kawm, thiab tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov lim kom zoo. Yog tias koj ntseeg tias tsab xov xwm no ua txhaum, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.
Nco tseg: Cov tshuaj no yuav tsum tau siv rau kev tshawb fawb nkaus xwb. Cov lus thov no tsis tau raug soj ntsuam los ntawm Food and Drug Administration. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv lawv. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho, lossis tiv thaiv txhua yam kab mob.
Cim npe nrov: indomethacin hmoov cas 53-86-1, Suav teb, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua nyob rau hauv Tuam Tshoj