Dab tsi yog leflunomide hmoov?
LEFLUNOMING, tseem hu ua Airuohua, leflomide, lossis Dongwa, yog ib qho imidazole immunisuppressant nrog anti proliferative kev ua si. Niaj hnub nimno muab cov khoom lag luam niaj hnub no tso cov khoom no ua cov tshuaj antipyretic, analgesic, thiab anti-inflampation tshuaj. Vim tias qhov nyuaj hauv kev kho cov tshuaj ntawm cov khoom no rau cov neeg mob hloov khoom siv, nws yog feem ntau yog siv los kho cov kab mob autoimmune xws li rheumatoid mob caj dab. Tom qab tswj qhov ncauj,Leflunomide hmoovtau hloov pauv sai sai rau hauv cov metabolites nyob rau hauv txoj hnyuv phab ntsa thiab nplooj siab, nrog ib f ntawm 80%. Kev noj mov tsis cuam tshuam kev nqus. TMAX yog 6-12} sijhawm. Yog tias thawj zaug tau muab nrog cov tshuaj thauj khoom ntawm 100mg, txwv tsis pub muaj nyob hauv 3 hnub, txwv tsis pub nws yuav siv sijhawm ntau lub hlis kom ncav cuag cov ntshav khov kho. Cov metabolite nquag PPB yog 99.3%, feem ntau tau muab faib rau daim siab, raum, thiab tawv nqaij, nrog tsawg dua hauv cov ntaub so ntswg. Tom qab cov metabolism ntxiv ntawm cov metabolism hauv cov metabolites, 43% ntawm cov cim tau tawm hauv cov zis thiab 48% hauv cov quav. T1 / 2 yog li 2 lub lis piam, thiab Enterohapatic Sworculation yog qhov tseem ceeb ua rau lub neej ntev dua-lub neej ntawm cov metabolites. Kev noj haus muaj roj tsis muaj qhov cuam tshuam tseem ceeb rau cov tshuaj ntshav ntshav. Ua kom cov pa roj carbon lossis choleseryl ua kom muaj zog tuaj yeem inhibit kev nqus tshuaj.
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Khoom npe |
Leflomide |
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Cas |
75706-12-6 |
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Molecular Cov Qauv |
C12H9F3N2O2 |
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Molecular hnyav |
270.21 |
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Einecs tooj |
616-254-6 | |
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Chaw Cia Khoom |
2-8 degree |
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|
Kev tshwm sim |
Cov hmoov dawb |
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Melting taw tes |
166.5 Qib |
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| Ceev |
1.392 {{0. 06g / cm3 (ntxhib kwv yees) |
Dab tsi yog leflunomide hmoov lub tshuab ua haujlwm ntawm kev nqis tes ua?
Leflunomide hmoovyog hloov kho sai sai rau hauv cov metabolites los ntawm cytoplasm thiab microshawnes dehydre dese dna syntheres (Dhodh), yog li txo kev noj ntawm nucleotides hauv B lymphocytes, kev txiav txim siab biosynthesis ntawm DNA thiab tus neeg tiv thaiv cov hlwb los ntawm kev nkag mus ua pov thawj, yog li ua rau anti rheumatic cuam tshuam. Nws yog tsim nyog rau kev kho mob ntawm cov neeg laus nquag mob caj dab thiab Ankylosing kev puas tsuaj, thiab muaj peev xwm qeeb pob txha ua rau muaj kev puas tsuaj, txo cov tsos mob thiab cov cim qhia. Tsis tas li ntawd, LEFLUNOMIDIDIDIDIDIDE tseem tuaj yeem ua rau muaj kev ua si ntawm Tyrrisine Kinases qhov kev nthuav dav ntawm T Cawv, thiab tsis muaj lub cev tiv thaiv kab mob. Nws tseem tuaj yeem ua rau anti-inflammatory los ntawm inhibitioning synibritis ntawm bclooksenase ntawm kev tso tawm ntawm cov tshuaj antamine hauv mast hlwb thiab eosinophils.
Dab tsi yog qhov siv thiab cov kev tshwm sim ntawmLeflunomide hmoov?
LEFLUNOMING HMOOV yog cov yeeb tshuaj nonsteroidal muaj immunosuppressive thiab anti-inflammatoratory, siv los kho cov neeg laus mob mob rheumatoid.
Xeev siab, ntuav, raws plab, mob plab, poob ntawm cov qab los noj mov lossis poob phaus: noj tshuaj tom qab cov kev mob tshwm sim tom qab. Ntxais cov khoom qab zib, thaj suab thaj tsis tau txo qis siab xeev thiab ntuav. Qhia rau koj tus kws kho mob yog cov tsos mob hnyav heev lossis yog tias koj muaj kev tsis qab los noj mov.
Mob taub hau, kiv taub, tsis muaj zog: feem ntau txhim kho thaum koj tau siv rau cov tshuaj.
Kev ploj ntawm cov plaub hau: nws tau thim rov qab thaum cov tshuaj nres.
Muaj ntshav siab: Xyuas koj cov ntshav siab tsis tu ncua. Tham nrog koj tus kws kho mob yog tias muaj ntshav siab rau koj cov ntshav siab.
Yog tias koj xav tau, koj tuaj yeem Nyem email:sales1@faithfulbio.com
Khoom Qhia Txog Khoom
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Cov khoom |
Tus qauv |
Qho kawg |
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Tus neeg |
Cov hmoov dawb |
Cov hmoov dawb |
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So |
Raws li tau teev tseg |
Ntuas |
|
Daim qhia npe |
Ua raws li tus qauv |
Ntuas |
|
Poob rau ziab |
Tsawg dua los yog sib npaug rau 0. 5% |
0.13% |
|
Ignition residue |
Tsawg dua los yog sib npaug rau 0. 1% |
0.09% |
|
Kev sim siab |
99.0%-101.0% |
99.5% |
Dab tsi yog cov txheej txheem ntau lawm ntawm lefunomideHmoov?
Ethyl acetoacetate, Triethyl orthoformate, thiab acetic anhydride tau refluxed ua ke kom txog thaum cov ntaub ntawv raw tau meej heev, ntev li 5 teev. Distillation sau ntawm 140, 150 xyoo /1.87KPA cov feem ntau cov feem ntau ua rau muaj kev sib txuas (I) nrog cov txiaj ntsig ntawm 85%. Compound (i) yog yaj nyob rau hauv cov ethanol thiab kev sib tov ntawm hydroxyloride, thiab dej ntxiv dropwise ntawm {}} degree rau 1 teev.
Tom qab dripping, hnov mob rau txog 8 teev. Ntxiv concochloric acid thiab glacial acetic acid, refux rau 5 teev. Siv rau 1/2 ntim hauv qab kev txo qis, txias rau hauv qab 10 degree, thiab recrystallize ntawm 145-146. 5 degree thiab muaj txiaj ntsig ntawm 80%. Compound (II) yog yaj nyob rau hauv thaleyl chloride yog ntxiv dropwise ntawm {8}} degree raws li wurhux li 3 teev. Mloog zoo, factate, thiab sau cov leb feem ntawm {10}} degree /} degree / iii) nrog ib tug tawm los ntawm 75%. Dissve trifluorethylaniline thiab triethylamine hauv dichlorompethans thiab ntxiv cov compound (III) Dropwise ntawm {{14} degree. Rov qab los ntawm 25-30 degree rau 3 teev. Ntxiv dej, cais cov organic txheej, ntxuav nrog dej, ntxuav nrog dej ntshiab, thiab qhuav. Mloog zoo rau 1/3 ntim nyob rau hauv kev txo qis, ntxiv petroleum ether, txias, txias, txias, txias, thiab recrystallize los ntawm ethyl acetate kom tau txais dawb crystalline hmoov ntawmleflunomide hmoovNrog lub ntsiab lus melting ntawm 166-167 degree thiab ib tug tawm los ntawm 81%.
Yuav ua li cas thiab qhov twg yuav leflomidehmoovKev lag luam wholesale?
Peb muaj 8 xyoo kev paub hauv kev muag cov tshuaj tshawb fawb txog kev cai lij choj thiab muaj lub koob npe zoo, ua rau peb tus khub uas ntseeg siab.
Peb paub tseeb tias qhov zoo ntawm peb cov khoom los ntawm kev sim ua haujlwm ywj pheej, thiab txhua tus neeg siv khoom yog peb VIP.
Xa koj qhov kev nug kom paub ntau ntxiv, Nyem Email:sales1@faithfulbio.comTam sim no.
Ntau hom kev xa khoom rau koj xaiv
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Tsheb Thauj Mus Los |
Shipping Txoj Kev |
Cargo Qhov hnyav |
Yam uas pab |
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3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau hauv qab 50kg. |
Peb muaj cov chaw khaws khoom hauv Tebchaws Yelemees thiab California, Asmeskas, |
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7-15 hnub |
Los ntawm huab cua |
Haum rau ntau tshaj 50kg. |
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15-60 hnub |
Los ntawm hiav txwv |
Haum rau ntau tshaj 500kg. |
Kev tsis lees paub: Cov lus ntawm lub vev xaib no yog siv rau kev tshawb fawb thiab kev kawm sib pauv. Thov ua tib zoo saib pom qhov tseeb ntawm lawv cov kev xav thiab cov ntsiab lus. Yog tias koj pom muaj kev ua txhaum. Thov hu rau tus thawj tswj hwm kom sai. Peb tsis yog lub luag haujlwm rau cov kev rau txim ntawm cov ntaub ntawv thiab cov kev pabcuam tau muab rau hauv lub vev xaib no.
Tsab ntawv: Cov khoom lag luam yog rau kev tshawb fawb tsuas yog siv thiab tsis yog rau kev kuaj mob, kev kho mob, tiv thaiv kab mob, thiab lwm yam.
Xa koj qhov kev nug kom paub meej ntxiv, nyem email:sales1@faithfulbio.comTam sim no.
Cim npe nrov: leflunomide hmoov cas no 75706-12-6, cov chaw muag khoom, tsheb tsim khoom, kev lag luam, cov khoom siv dawb, khoom siv raw, ua hauv Phiaj suav