Mirogabalin Besylate API CAS 1138245-21-2
Khoom npe: Mirogabalin besylate
Lub ntsiab lus: Mirogabalin besylat; Mirogabalin Besilate; MIROGABALIN BENZENESULFONIC ACID; Mirogabalin Besylate 10928
CAS Nr .: 1138245-21-2
EINECS NO.:/
Cov mis mos molecular: C18H25NO5S
Purity & Qib: 99%; Qib tshuaj
Cim: Dawb hmoov
Cov qauv dawb: Muaj
Tshuag: Hauv Tshuag
Warehouse: USA/EU/AU Warehouse
MOQ & Pob: 1g; Pob raws li xav tau
Shipping: Kev nyab xeeb thiab xa khoom sai
Lub Sijhawm Lead: 5-10 hnub
Khw & Txee lub neej: Txias & qhuav qhov chaw; 24 hli
Hauj lwm lawm
Khoom piav qhia
Mirogabalin besylate API CAS 1138245-21-2yog ib yam khoom tshiab analgesic teej tug mus rau chav Gabapentin. Nws exerts nws cov nyhuv analgesic los ntawm inhibiting calcium -mediated neurotransmitter tso tawm nyob rau hauv voltage-gated calcium channels (VGCCs), tshwj xeeb tshaj yog los ntawm kev khi rau 2δ-1 subunit. Nws muaj kev sib raug zoo siab rau ob qho tib si 2δ-1 thiab 2δ-2 subunits, uas cuam tshuam nrog kev ua haujlwm ntawm kev ua xua (2δ-1) thiab cov kev mob tshwm sim hauv nruab nrab paj hlwb (2δ-2). Ib qho tseem ceeb ntawm Mirogabalin besylate yog nws qhov kev sib cais ntev ib nrab-lub neej (tshaj 11 teev ntawm 2δ-1), uas ntev dua li ntawm pregabalin (kwv yees li 1.5 teev ntawm 2δ-1 thiab 2δ-2). Cov cuab yeej no tau ntseeg tias yuav pab txhawb rau nws cov txiaj ntsig zoo thiab ua kom ntev ntev thaum txo cov kev mob tshwm sim cuam tshuam nrog Gabapentin zoo li cov khoom.
Cov ntawv thov tseem ceeb
Mob ntshav qab zib peripheral neuropathy (DPNP): Ua kom cov neeg mob txo qis qhov mob nruab nrab txhua hnub.
Postherpetic neuralgia (PHN): Ua kom pom kev ua tau zoo dua piv rau cov placebo hauv ntau theem III kev sim tshuaj.
Postoperative neuralgia: Cov kev tshawb fawb tsis ntev los no qhia tau hais tias nws kuj txhim kho trigeminal neuralgia tom qab pob txha taub hau hauv paus kev phais.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
COA
| Kev sim | Specifications | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb hmoov | ua raws |
| Purity (HPLC) | Ntau dua lossis sib npaug li 98% | 99.90% |
| Cov ntsiab lus dej (KF) | Tsawg dua lossis sib npaug li 5% | 2.69% |
| Methanol (los ntawm GC) | Tsawg dua lossis sib npaug li 1% | 0.02% |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 2% | 0.00% |
| Cov ntsiab lus ntawm cov hlau hnyav (AAS) | ||
| Pb | Tsawg dua los yog sib npaug li 0.5 ppm | N.D |
| Raws li | Tsawg dua los yog sib npaug li 0.5 ppm | N.D |
| Hg | Tsawg dua los yog sib npaug li 0.5 ppm | N.D |
| Cd | Tsawg dua los yog sib npaug li 0.5 ppm | N.D |
| Xaus | Ua raws li kev lag luam specification | |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
Cov mis mos molecular: C18H25NO5S
Molecular Luj: 367.460
PIB: 367.145355
InChIKey OKJXJRVWXYRSAN-TXULWXBWSA-N
SMILES CCC1=CC2C(C1)CC2(CN)CC(=O)OO=S(=O)(O)c1ccccc1
Cia txias: 2-8 degree
Pharmacological Mechanism of Action ntawm Mirogabalin Besylate API CAS 1138245-21-2
Nws xaiv thiab nrog siab affinity khi rau ₂δ-1 subunit ntawm voltage-gated calcium channels (Kd≈13.5 nM), nrog tsawg affinity rau ₂δ-2.
Nws inhibits calcium influx mus rau hauv dorsal cag ganglion (DRG) thiab presynaptic cheeb tsam ntawm tus txha caj qaum, txo qhov tso tawm ntawm qhov mob neurotransmitters xws li glutamate, tshuaj P, thiab calcitonin noob- ntsig txog peptide, yog li thaiv qhov mob teeb liab kis.
Nws dissociates maj mam los ntawm ₂δ-1, uas ua rau lub sij hawm ntev analgesic nyhuv; nws qhov kev xaiv qis rau ₂δ-2 ua rau muaj kev cuam tshuam tsawg dua hauv nruab nrab (kiv taub hau, tsaug zog).
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
vim li cas xaiv peb
Peb lub Hoobkas
Pob
Shipping Txoj Kev
|
Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
|
3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, thiab cov neeg muas zaub nyob rau hauv cov teb chaws Europe thiab America muaj peev xwm txaus siab rau xa cov khoom ncaj qha los ntawm ob qhov chaw. |
|
7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
|
|
15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
FAQ
01. Dab tsi yog txoj hauv kev tseem ceeb ntawm excretion rau Mirogabalin besylate API CAS 1138245-21-2?
Nws yuav luag tag nrho excreted unchanged ntawm ob lub raum, ho cuam tshuam rau lub raum ua haujlwm.
02. Dab tsi yog qhov tshwm sim tsis zoo ntawm Mirogabalin besylate API CAS 1138245-21-2?
kiv taub hau, tsaug zog, qaug zog, qhov ncauj qhuav, cem quav, peripheral edema, hnyav nce, thiab lwm yam.
03. Kuv tuaj yeem yuav Mirogabalin besylate API CAS 1138245-21-2 qhov twg?
Cim npe nrov: mirogabalin besylate api cas 1138245-21-2, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, kev muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua nyob rau hauv Suav teb
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