Rapamycin hmoov(sirolimus hmoov) yog ib yam tshiab ntawm macrolide immunosuppressant. Nws yog hmoov dawb nrog lub melting point ntawm 183-185 degree . Nws yog lipophilic thiab yooj yim soluble hauv methanol, ethanol, acetone, chloroform, thiab lwm yam organic Solvent, me ntsis soluble hauv dej, thiab yuav luag insoluble hauv ether. Nws tau tsim thaum ntxov li xyoo 1970 thiab yog thawj zaug siv los ua tshuaj tiv thaiv kab mob qis. Nws tau pom nyob rau xyoo 1977 tias nws muaj cov tshuaj tiv thaiv kab mob. Txij li xyoo 1989, RAPA tau raug sim ua tshuaj tshiab rau kev kho mob ntawm kev hloov pauv hauv nruab nrog cev. Los ntawm cov txiaj ntsig ntawm kev sim tsiaj thiab kev siv tshuaj kho mob, nws yog ib hom tshuaj tiv thaiv kab mob tshiab nrog cov nyhuv curative zoo, tsis muaj tshuaj lom, thiab tsis muaj nephrotoxicity.
Nws yog cov tshuaj tua kab mob macrolide, zoo ib yam hauv cov qauv rau FK506, tab sis nws txoj kev tiv thaiv kab mob sib txawv kiag li. FK506 inhibits qhov kev loj hlob ntawm T lymphocytes los ntawm G0 mus rau G1, thaum Rapamycin thaiv cov teeb liab hloov mus los ntawm cov cytokine receptors sib txawv, thaiv kev loj hlob ntawm T lymphocytes thiab lwm cov hlwb los ntawm G1 mus rau S. Piv nrog FK506, Rapamycin tuaj yeem thaiv calcium-dependent thiab ywj siab teeb liab transduction. Txoj kev ntawm calcium-T lymphocytes thiab B lymphocytes.
Nws yog cov tshuaj tua kab mob macrolide tau los ntawm actinomycetes, thiab nws cov qauv zoo ib yam li FK506. Tab sis muaj cov txheej txheem sib txawv ntawm kev tiv thaiv kab mob. Rapamycin thaiv cov teeb liab hloov mus los ntawm ntau yam cytokine receptors, xws li inhibiting cell proliferation induced by IL-2 thiab IL-4, IL-1 induced IFN- ntau lawm, thiab IL-2 thiab IL -2R induction Qhov kev qhia ntawm daim nyias nyias antigen thaiv cov ntaub ntawv hloov pauv txoj hauv kev tom qab kev khi ntawm IL-2 thiab IL-2r, yog li thaiv cov txheej txheem ntawm T lymphocytes thiab lwm cov hlwb los ntawm G1. mus rau theem S. Piv nrog FK506, RAPA tuaj yeem thaiv cov calcium-dependent thiab calcium-yooj yim teeb liab transduction txoj kev ntawm t-lymphocytes thiab b-lymphocytes.
|
|
| Cov duab tiag tiag ntawm Sirolimus hmoov | Sirolimus Structure Diagram |
Khoom siv
1. Rapamycin hmoovyog ib qho tshuaj tiv thaiv kab mob tshiab thiab muaj txiaj ntsig zoo nrog kev ua haujlwm tiv thaiv kab mob.
2. Nws yog ib tug tswv cuab ntawm tsev neeg macrolide immunosuppressant.
3. Nws yog lub substrate ntawm cytochrome P450 III A4 (CYP3A4) thiab P- glycoprotein.
4. Nws yog qhov tsim nyog rau cov neeg mob tau txais kev hloov hauv lub raum kom tsis txhob muaj lub cev tsis zoo.
Khoom Specification
Yam khoom | Specification | Cov txiaj ntsig |
Kev piav qhia | tawm-dawb mus rau daj crystalline hmoov | Ua raws |
Kev txheeb xyuas | IR spectrum ntawm Potassium Bromide kev npaj ntawm cov qauv qhia maxima ntawm tib lub wavelengths raws li qhov kev npaj zoo sib xws ntawm cov qauv siv hauv tsev | Ua raws |
UV spectrum ntawm 95% Ethanol npaj ntawm cov qauv nthuav tawm maxima ntawm 267nm, 277nm, thiab 288nm uas zoo sib xws ntawm kev npaj hauv tsev siv tus qauv. | Ua raws | |
Lub sijhawm khaws cia ntawm qhov siab tshaj plaws rau Trans- thiab Cis-stereoisomers hauv chromatogram ntawm Assay kev npaj sib raug rau qhov hauv chromatogram ntawm tus qauv kev npaj, raws li tau txais hauv Assay | Ua raws | |
Poob rau ziab | Tsawg dua los yog sib npaug rau 0.5% | 0.16% |
Hnyav hlau | Tsawg dua lossis sib npaug rau 0.002% | Ua raws |
Tag nrho impurity | Tsawg dua lossis sib npaug rau 2.0% | 0.76% |
Ib leeg impurity | Tsawg dua lossis sib npaug rau 1.0% | 0.67% |
Cis-stereoisomer ntawm Sirolimus | Tsawg dua lossis sib npaug rau 5.0% | 2.4% |
Assay | Ntau dua lossis sib npaug rau 98.0% | 99.2% |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Koj tuaj yeem tiv tauj kuv ntawm WhatsApp:+86 13137770562
Muaj ntau txoj kev xa khoom rau koj xaiv
Tsheb thauj mus los | Shipping txoj kev | Cargo hnyav xav tau | Qhov zoo |
3-7 hnub | DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, | Haum rau qis dua 50kg. | Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, lub teb chaws USA, |
7-15 hnub | Los ntawm Cua | Haum rau ntau tshaj 50kg. | |
15-60 hnub | Los ntawm Hiav Txwv | Haum rau ntau tshaj 500kg. |
Tsis lees paub: Cov ntawv luam tawm ntawm lub vev xaib no yog siv los txhawb kev sib pauv kev kawm thiab kev kawm, thiab tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov lim kom zoo. Yog tias koj ntseeg tias tsab xov xwm no ua txhaum, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.
Nco tseg: Cov tshuaj no yuav tsum tau siv rau kev tshawb fawb nkaus xwb. Cov lus thov no tsis tau raug soj ntsuam los ntawm Food and Drug Administration. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv lawv. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho lossis tiv thaiv kab mob.
Cim npe nrov: rapamycin hmoov cas 53123-88-9, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, kev muag khoom