Quinine yog dab tsi?
Quinine yog alkaloid rho tawm los ntawm cinchona bark, uas muaj nyob rau hauv cinchona bark ntawm Rubiaceae. Nws muaj cov nyhuv antimalarial. Quinine yog ib qho potassium channel inhibitor uas tuaj yeem cuam tshuam cov +100 mV tam sim no ntawm MT mSlo3 (KCa5.1) channel induced los ntawm voltage pulses, thiab nws cov nqi IC50 yog 169 μM.
Quinine hmoovyog ib tug dawb crystalline hmoov nrog me ntsis weathering zog. Nws tsis muaj ntxhiab thiab iab me ntsis. Nws yog me ntsis soluble hauv dej thiab glycerol, yooj yim soluble hauv ethanol, chloroform, thiab soluble hauv dilute acid thiab dilute ammonia dej. Nws muaj zog xiav fluorescence nyob rau hauv sulfuric acid. Nws yog ib qho yooj yim los tsim cov ntsev nrog ntau cov kua qaub. Melting point: 173-177 degree Kev sib hloov: -145.2 degree (ethanol)
Quinine feem ntau pom muaj nyob rau hauv cov tawv ntoo los yog cag ntoo ntawm liab cinchona ntoo los yog cinchona Rai, nroj tsuag ntawm Rubiaceae. Quinine crystallized nyob rau hauv benzene yog koob-zoo li crystals uas muaj cov kuab tshuaj, uas maj mam poob cov kuab tshuaj nyob rau hauv cov huab cua thiab ua me me crystalline anhydrous tshuaj. Nws yog insoluble nyob rau hauv dej, soluble nyob rau hauv ethanol, chloroform thiab boiling benzene, thiab soluble nyob rau hauv anhydrous ether (1:250). Muaj ob lub nitrogen atoms nyob rau hauv lub quinine molecule, uas cov nitrogen atom nyob rau hauv lub quinine nucleus yog nyob rau hauv ib tug tertiary amine lub xeev, muaj zog alkalinity, thiab muaj peev xwm tsim ntsev nrog acids, muaj zog iab saj. Quinine sulfate dihydrate yog dawb, zoo koob zoo li siv lead ua, mos, yooj yim rau compress, tsis muaj ntxhiab, iab heev, thiab maj mam hloov xim thaum raug teeb. Nws yog yooj yim soluble nyob rau hauv ib tug sib tov ntawm chloroform thiab anhydrous ethanol (2: 1), thiab me ntsis soluble nyob rau hauv dej, ethanol, chloroform thiab ether.
| Khoom npe | Quinine |
| CAS | 130-95-0 |
| Cov mis mos molecular | C20H24N2O2 |
| Molecular hnyav | 324.42 |
| EINECS Number | 205-003-2 |
| Kev cia khoom | Khaws nyob rau hauv qhov chaw tsaus, inert cua, chav tsev kub |
| Melting point | 173-175 degree (lit.) |
| Solubility | Soluble hauv dej |
| Qhov tshwm sim | Dawb crystalline hmoov |
| Boiling point | 462.75 degree (kev kwv yees ntxhib) |
| Qhov ntom | 1.1294 (zeeg) |
Cov tshuaj pharmacological ntawm Quinine yog dab tsi?
Quinine yog quinoline derivative uas muaj zog tua cov nyhuv ntawm erythrocytic schizonts ntawm ntau yam kab mob malarial. Quinine tuaj yeem khi rau DNA ntawm malarial parasites los ua ib qho nyuaj, inhibit DNA replication thiab RNA transcription, thiab yog li inhibit cov protein synthesis ntawm cov cab, tab sis nws cov nyhuv tsis muaj zog dua li ntawm chloroquine. Quinine tseem tuaj yeem txo cov pa oxygen noj ntawm malarial parasites, inhibit phosphorylase hauv malarial parasites thiab cuam tshuam nrog lawv cov piam thaj metabolism. Quinine kuj ua rau hemochromatin aggregation, tab sis txoj kev loj hlob qeeb thiab tsis tshua muaj cov kab loj. Nyob rau hauv cov ntshav, ib tug tej yam concentration ntawmQuinine hmoovtuaj yeem ua rau ntxov ntxov rupture ntawm parasitized qe ntshav liab, yog li tiv thaiv kev loj hlob ntawm schizonts. Quinine tsis muaj txiaj ntsig tawm tsam erythrocytic theem thiab tsis tuaj yeem kho benign malaria. Kev kho mob mus sij hawm ntev tuaj yeem kho tus mob malaria, tab sis nws tsis muaj kev cuam tshuam ncaj qha rau gametocytes ntawm malignant malaria, yog li nws tsis tuaj yeem cuam tshuam kev sib kis. Tsis tas li ntawd, Quinine muaj cov nyhuv inhibitory ntawm myocardium, uas tuaj yeem ua kom ntev lub sijhawm refractory, qeeb conduction, thiab ua rau nws tsis muaj zog.
Khoom Specification
| Yam khoom | Specification | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb hmoov |
Ua raws |
| Kev kho hniav | HPLC-Ua raws tus qauv | Ua raws |
| Saj | Tasteless | Ua raws |
| Quinine HCL | 99% | 99.4% |
| Oss on Drying | Tsawg dua lossis sib npaug rau 5.0% | 3.1% |
| Tshauv | Tsawg dua lossis sib npaug rau 1.0% | 0.3% |
| Qhov ntom ntom | 0 30-0.40g/ml | 0.31g/ml |
| Kev tsom xam Sieve | 100% txog 80 mesh | Ua raws |
| Cov hlau hnyav | ||
| Tag nrho hnyav hlau li ead | Tsawg dua lossis sib npaug li 10ppm | Ua raws |
| Raws li | Tsawg dua los yog sib npaug rau lppm | 0.25ppm |
| Cadmium | Tsawg dua lossis sib npaug rau 0.3ppm | 0.08ppm |
| ua ed | Tsawg dua los yog sib npaug rau lppm | 0.6ppm |
| Mercury | E 0.1ppm | 0.08ppm |
| Chromium VMCr) | k2 pwm | 0.5ppm |
| Tag nrho cov hlau hnyav uas ead |
Tsawg dua lossis sib npaug li 10ppm | Ua raws |
| Raws li | Tsawg dua los yog sib npaug rau lppm | 0.25ppm |
| Cadmium | Tsawg dua lossis sib npaug rau 0.3ppm | 0.08ppm |
| Xaus: | Ua raws li kev lag luam Specification. |
Dab tsi yog qhov cuam tshuam thiab kev ua haujlwm ntawm quinine?
Quinine yog ib hom tshuaj ntuj uas muaj ntau yam tshuaj muaj txiaj ntsig thiab tau siv dav hauv kev kho mob. Cov teebmeem tshwj xeeb thiab kev ua haujlwm yog raws li hauv qab no:
1. Antimalarial nyhuv: Quinine yog ib qho ntawm cov khoom uas nyiam siv los kho malaria. Nws tuaj yeem tua cov kab mob malarial thiab txo cov tsos mob.
2. Anti-inflammatory effect: Quinine muaj cov tshuaj tiv thaiv kab mob, uas tuaj yeem txo cov kev mob tshwm sim, txo qhov mob thiab o.
3. Cov nyhuv relaxant: Quinine tuaj yeem cuam tshuam cov leeg nqaij thiab txo cov leeg nqaij thiab mob.
Txawm tiasquinine hmoovmuaj ntau yam teebmeem, nws tseem yuav tsum tau them sai sai rau qhov ntau npaum thiab cov lus qhia thaum siv nws kom tsis txhob muaj kev phiv tshuaj.
HTML5 atlas of Quinine
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IR1 ntawm Quinine
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Quinine tuaj yeem siv rau dab tsi?
1. Nws tuaj yeem siv los ua kev tshuaj ntsuam reagent
2. Nws yog cov tshuaj tiv thaiv kab mob potassium. Chiral catalyst, siv rau cov isomer-xaiv [2+2] cycloaddition cov tshuaj tiv thaiv; Diethyl zinc ntxiv rau aldehydes.
3. Quinine muaj ib tug muaj zog tua nyhuv ntawm asexual theem ntawm ntau yam malarial parasites. Quinine dihydrochloride zoo tiv thaiv chloroquine-resistant malignant malaria, tab sis feem ntau yuav tsum muaj ntau dua; Nws kuj tseem siv tau los tiv thaiv kab mob npaws paj hlwb thiab feem ntau siv los cawm cov kab mob cerebral malaria.
4. Quinine sulfate yog siv los kho thiab tiv thaiv kab mob npaws, tshwj xeeb tshaj yog rau vivax malaria. Tsis tas li ntawd, Quinine hmoov muaj cov txiaj ntsig ntawm kev ua kom kub taub hau thiab txhawb nqa uterine contraction.
Qhov txawv ntawm Artemisinin thiab Quinine yog dab tsi?
1. Mechanism ntawm kev txiav txim:
Quinine tuaj yeem khi rau DNA ntawm malarial parasites los ua ib qho nyuaj, yog li ncaj qha inhibiting DNA replication thiab transcription, ua rau lub neej txawv txav ntawm malarial parasites; hom kev txiav txim ntawm artemisinin tseem tsis tau paub meej, tab sis cov kev tshawb fawb tau pom tias nws tuaj yeem thaiv qhov ntxov tshaj plaws ntawm malarial parasite khoom noj khoom haus, ua rau malarial parasites tshaib plab rau cov amino acids sai dua, sai sai tsim autophagic vacuoles, thiab tsis tu ncua tshem tawm sab hauv. cytoplasm los ntawm cov kab mob cab, ua rau tuag ntawm malarial parasites.
2. Qhov chaw ntawm cov khoom xyaw:
Quinine hmoovyog muab rho tawm los ntawm cov tawv ntoo ntawm cinchona ntoo thiab muaj tus nqi siab; artemisinin yog ib qho metabolite muab rho tawm los ntawm cov ntaub so ntswg ntawm cov nroj tsuag Artemisia annua, thiab cov khoom siv raw yog dav, yog li nws cov nqi qis.
3. Cov lus qhia:
Quinine yog siv los kho tus mob malaria los ntawm cov kab mob chloroquine tiv thaiv thiab ntau yam tshuaj, thiab tseem tuaj yeem siv los kho vivax malaria; artemisinin yog tsim rau kev tswj cov tsos mob ntawm ntau hom malaria, tshwj xeeb tshaj yog rau malignant thiab hnyav malaria resistant rau chloroquine Cheebtsam.
Hauv luv luv, txawm hais tias ob qho tib si artemisinin thiab quinine muaj cov tshuaj tiv thaiv kab mob, muaj qhov sib txawv ntawm ntau yam, los ntawm cov khoom xyaw rau cov txheej txheem ntawm kev ua.
Kev ceev faj ntawm Quinine hmoov yog dab tsi?
1. Cov poj niam cev xeeb tub raug txwv tsis pub siv Quinine vim tias nws muaj kev cuam tshuam kev ua haujlwm thiab tuaj yeem dhau los ntawm cov placenta kom muaj kev cuam tshuam rau tus menyuam hauv plab. Siv ceev faj rau cov poj niam lactating.
2. Kev cuam tshuam nrog kev kuaj mob: Quinine tuaj yeem cuam tshuam nrog kev txiav txim siab ntawm 17-hydroxysteroids.
3. Nws yuav tsum tau siv nrog ceev faj rau cov neeg mob hawb pob, mob plawv, qabzib -6-phosphate dehydrogenase deficiency, myasthenia gravis, thiab optic neuritis.
4. Quinine ua ke nrog antacids, anticoagulants, cov leeg nqaij so, quinidine, tso zis alkalinizers, vitamin K, thiab lwm yam yuav tsim kev sib cuam tshuam ntawm cov tshuaj, uas yuav tsum tau them nyiaj rau.
Yuav ua li cas thiab qhov twg yuav Quinine hmoov lag luam wholesale?
Koj tuaj yeem tso siab rau peb qhov kev txiav txim vim tias peb muaj cov ntaub ntawv zoo ntawm kev muag tshuaj raws cai.
Peb ua qhov kev kuaj xyuas ywj pheej ntawm txhua yam khoom thiab tom qab ntawd muag rau peb cov neeg siv khoom hwm.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Muaj ntau txoj kev xa khoom rau koj xaiv
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Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
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3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
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7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Tsis lees paub: Cov ntawv luam tawm ntawm lub xaib no yog siv los txhawb kev sib pauv kev kawm thiab kev kawm, thiab tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov lim kom zoo. Yog tias koj ntseeg tias tsab xov xwm no ua txhaum, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.
Nco tseg: Cov tshuaj no yuav tsum tau siv rau kev tshawb fawb nkaus xwb. Cov lus thov no tsis tau raug soj ntsuam los ntawm Food and Drug Administration. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv lawv. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho, lossis tiv thaiv txhua yam kab mob.
Cim npe nrov: quinine hmoov cas 130-95-0, Suav teb, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua nyob rau hauv Tuam Tshoj