Selexipag API yog dab tsi?
Xi'an Faithful BioTech Co., Ltd., lub siab -tech export biotech lub tuam txhab nyob hauv Xi'an, muab cov kev pabcuam sib koom ua ke suav nrog kev tshawb fawb & kev tsim kho, kev tsim khoom loj thiab kev faib thoob ntiaj teb. Peb muaj ntau tshaj 10 xyoo ntawm kev paub nyob rau hauv biomaterials thiab zoo tshuaj, nrog rau cov khoom muaj peev xwm nyob rau hauv kev tshawb fawb technology thiab manufacturing.Selexipag API(CAS: 475086-01-2, C₂₆H₃₂N₄O₄S) yog cov hmoov dawb mus rau dawb crystalline hmoov. Nws yog ib qho kev xaiv ntau yam prostacyclin receptor agonist. Ua tsaug rau nws cov qauv molecular txawv thiab lub hom phiaj ua haujlwm, nws yog ib qho khoom siv ua haujlwm rau pulmonary hypertension. Txo cov theem ntawm prostacyclin thiab lwm yam synthase nyob rau hauv lub ntsws ua rau pulmonary hypertension, nrog rau aggravated pulmonary vasoconstriction thiab siab siab. Selexipag khi rau prostacyclin receptors los simulate kev ua haujlwm ntawm ntuj prostacyclin. Nws relaxes pulmonary hlab ntsha, nthuav cov hlab ntsha, txo pulmonary arterial siab thiab txhim kho cov ntshav khiav.
Piv nrog cov khoom zoo sib xws,Selexipag APImuaj kev ruaj ntseg zoo dua, tsis yog -hygroscopic thiab lub teeb-resistant. Nws lub xeev ruaj khov nyob ruaj khov ntawm chav tsev kub rau lub sijhawm ntev, zoo tagnrho rau kev siv sijhawm ntev - siv tas mus li.
Selexipag Manufacturing txheej txheem
Kev lag luam synthesis ntawm Selexipag muaj tsib kauj ruam. Pib nrog heterocyclic raw khoom, cov txheej txheem muaj xws li aminoalkylation, N-isopropylation, oxyalkylation, thiab hydrolysis ntawm tert-butyl ester. Thaum kawg, cov khoom nyoos yog tau los ntawm condensation nrog methanesulfonamide siv carbodiimide catalysis. Cov khoom tiav yog tau tom qab ntau recrystallizations rau purification. Cov txheej txheem zoo suppresses impurity tsim los ntawm optimizing cov tshuaj tiv thaiv kab mob thiab kub tswj. Nws yooj yim rau kev khiav lag luam, muaj ib qho yooj yim - los - tswj cov kuab tshuaj residue, thiab sib npaug cov nqi tsim khoom thiab cov khoom zoo.
COA
| Cov khoom kuaj | Specification | Kev tshwm sim |
| Qhov tshwm sim | Dawb hmoov | Ua raws |
| Specification | 99% | Ua raws |
| tsw | Yam ntxwv | Ua raws |
| Particle loj | 100% dhau 80 mesh | Ua raws |
| Cov hlau hnyav | ||
| Total Heavy metals | Tsawg dua lossis sib npaug li 10ppm | Ua raws |
| Microbial | ||
| Tag nrho microbacterial suav | Tsawg dua lossis sib npaug li 1000cfu / g | Ua raws |
| Poov & Mould | Tsawg dua lossis sib npaug li 100cfu / g | Ua raws |
| Escherichia Coli muaj nyob | Tsis zoo | Ua raws |
| Salmonella | Tsis zoo | Ua raws |
| Staphylococcus | Tsis zoo | Ua raws |
| Xaus | Ua raws li kev lag luam specification | |
Nyem email:sales4@faithfulbio.comLos yog WhatsApp:+86 17782784907
Qhov ceev 1.2 ± 0.1 g / cm3
Cov mis mos molecular C26H32N4O4S
Molecular Luj: 496.622
496.214417
PSA 113.36000
LogP 4.56
InChIKey QXWZQTURMXZVHJ-UHFFFAOYSA-N
Mechanism ntawm kev txiav txim ntawm Selexipag
Lub Hom Phiaj Ua Haujlwm: Ib qho kev xaiv prostacyclin receptor (IP receptor) agonist uas xaiv khi rau thiab qhib IP receptors hauv cov hlab ntsha.
Vasodilation: Ua kom cov hlab ntsws thiab cov hlab ntsha ua haujlwm tsis zoo, txo cov hlab ntsws vascular siab thiab pulmonary vascular resistance, thiab alleviating txoj cai ventricular load.
Inhibition of Proliferation/Remodeling: Inhibits abnormal proliferation of pulmonary vascular smooth muscle cells, slows pulmonary vascular remodeling, thiab tiv thaiv kev loj hlob ntawm pulmonary hypertension.
Txhim kho ntshav khiav: Ua kom lub plawv tso zis thiab pulmonary ntshav txaus, txhim kho kev ua haujlwm siab thiab kev ua haujlwm zoo.
Ntev - Qhov Zoo Tshaj Plaws ntev: Cov metabolites kuj muaj cov haujlwm IP agonist, uas ua rau muaj cov nyhuv vasodilatory ruaj khov thiab ruaj khov.
vim li cas xaiv peb
Peb ua raws li lub hauv paus ntsiab lus ntawm "tus neeg siv khoom ua ntej, kev ua siab ncaj ua ntej", thiab ib txwm muab cov neeg siv khoom nrog cov khoom zoo thiab muaj txiaj ntsig zoo thiab - cov kev pabcuam zoo. Xaiv kev ncaj ncees. Xaiv lub neej noj qab nyob zoo!
Nrog rau peb cov kev siv zog tas mus li thiab kev pabcuam zoo, peb cia siab tias yuav tsim kom muaj kev koom tes ntev - thiab kev loj hlob zoo nrog cov neeg siv khoom thiab muab sijhawm rau peb. Peb ntseeg tias peb yuav ua rau koj txaus siab rau thawj -chav kawm zoo, nyab xeeb thiab xa khoom sai thiab txaus siab tom qab- kev muag khoom.
Peb lub Hoobkas
Pob
Shipping Txoj Kev
|
Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
|
3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, thiab cov neeg muas zaub nyob rau hauv cov teb chaws Europe thiab America yuav txaus siab rau xa cov khoom ncaj qha los ntawm ob qhov chaw. |
|
7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
|
|
15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
FAQ
01. Lub hom phiaj tseem ceeb ntawm Selexipag yog dab tsi?
Nws ua rau cov kev xaiv ntau heev prostacyclin IP receptor, ua rau nws tus IP receptor agonist.
02. Dab tsi yog qhov tshwm sim tsis zoo ntawm Selexipag?
Mob taub hau, raws plab, xeev siab, mob musculoskeletal, dej ntws, arthralgia, thiab lwm yam, feem ntau cuam tshuam rau nws cov vasodilatory teebmeem.
03. Qhov twg lub cev feem ntau metabolizes thiab excretes Selexipag?
Selexipag APIFeem ntau metabolized nyob rau hauv daim siab, nrog rau feem ntau cov khoom metabolic tawm los ntawm ob lub raum.
Nyem email:Sales4@Faithfulbio.ComLos yog WhatsApp:+86 17782784907
Cim npe nrov: selexipag api cas 475086-01-2, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, kev muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua nyob rau hauv Suav teb