Sitagliptin Phosphate Monohydrate API CAS 654671-77-9

Sitagliptin Phosphate Monohydrate APIcode MK-0431 tau pom zoo los ntawm FDA thaum Lub Kaum Hli 2006 rau kev kho mob ntshav qab zib hom 2. Cov kev sim tshuaj pom tau tias nws muaj txiaj ntsig zoo hauv kev kho mob ntshav qab zib hom 2. Raws li hom tshiab ntawm cov khoom siv hypoglycemic raw khoom, nws tsis tsuas yog muaj qhov zoo ntawm cov ntshav qab zib dependence thiab cov nyhuv hypoglycemic nruab nrab, tab sis kuj nce insulin secretion yam tsis muaj hypoglycemia thiab txo cov kev tshaib kev nqhis. Hauv kev tshawb nrhiav daim ntawv thov, nws kuj tsis muaj kev phiv xws li xeev siab, ntuav, edema thiab hnyav nce.

Dab tsi yog pharmacological kev txiav txim ntawm sitagliptin phosphate monohydrate?

DPP-4 (tseem hu ua CD26) yog ib qho enzyme uas nthuav tawm ntawm T cells thiab ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob. Ntxiv rau qhov degrading incretin, DPP-4 tuaj yeem ua rau hydrolyze ntau yam bioactive peptides, suav nrog kev loj hlob hormone tso tawm cov tshuaj hormones, neuropeptide Y, pituitary adenylate cyclase activating peptide, thiab gastrin tso peptide. Ntawm lawv, glucagon zoo li peptide-1 muaj ib nrab-lub neej luv luv hauv plasma (t ₁ / ₂ ≈ 1 feeb) thiab yooj yim degraded los ntawm DPP-4. Raws li cov txheej txheem no, cov khoom siv raw khoom tsim kho rau txoj hnyuv insulinotropic feem ntau tsom rau ob qho lus qhia hauv qab no:
1: Nws yog kev txhim kho peptide analogs uas tsis yooj yim degraded los ntawm DPP-4 thiab tuaj yeem qhib GLP-1 receptors, xws li 2005 FDA pom zooExenatide. Nws tuaj yeem simulate physiological teebmeem ntawm GLP-1 thaum zam kev degradation sai los ntawm DPP-4.
2: Peb tab tom tsim DPP-4 inhibitors, sawv cev los ntawm sitagliptin. Kev tshawb fawb tau qhia tiasSitagliptin phosphate monohydrate API 98% puritytuaj yeem txhim kho kev ua haujlwm thiab qib ntawm endogenous GLP-1 thiab qabzib nyob ntawm insulinotropic peptides los ntawm kev xaiv inhibiting DPP-4. Vim nws cov ntshav qabzib nyob ntawm insulin secretion txhawb nqa cov txiaj ntsig, nws tuaj yeem txo qis kev pheej hmoo ntawm hypoglycemia los ntawm cov tshuaj hypoglycemic nyoos hmoov. Lub caij no, nws nthuav tawm cov kev xaiv siab ntawm DPP-4 (nrog rau qhov kev xaiv ntawm kwv yees li 2600: 1 rau DPP-8 / DPP-9), ua rau nws tsis tshua muaj kev cuam tshuam los ntawm kev cuam tshuam ntawm DPP-8 / DPP-9. Tsis tas li ntawd, nws cov txiaj ntsig ntawm kev nce qib GLP-1 yog qhov me me, uas yuav pab kom tsis txhob muaj kev mob plab hnyuv xws li xeev siab thiab ntuav los ntawm GLP-1 ntau dhau.

Dab tsi yog qhov zoo thiab qhov tsis zoo ntawm Sitagliptin phosphate monohydrate API piv nrog rau lwm yam DPP-4 inhibitors (xws li saxagliptin)?

Sitagliptin phosphate monohydrate APIthiab saxagliptin yog ob qho tib si DPP-4 inhibitors, thiab lawv cov teebmeem hypoglycemic feem ntau sib npaug, tab sis muaj qhov sib txawv ntawm cov tshuaj pharmacokinetics, pharmacology kev sib cuam tshuam thiab kev nyab xeeb. Qhov kev sib piv tshwj xeeb yog raws li hauv qab no:

Dab tsi yog qhov tsis zoo tshwm sim ntawm Sitagliptin phosphate monohydrate API?

Sitagliptin phosphate monohydrate APImuaj kev zam zoo tag nrho, thiab cov kev tsis zoo tshwm sim muaj xws li nasopharyngitis, mob taub hau, kiv taub hau, tsis xis nyob hauv plab, cem quav, raws plab, thiab ua pob liab liab, uas feem ntau mob me me thiab feem ntau nws tus kheej txwv. Txawm li cas los xij, yuav tsum tau ceev faj txog qhov tsis tshua muaj tab sis muaj kev pheej hmoo loj xws li hypoglycemia (tshwj xeeb tshaj yog thaum ua ke nrog cov tshuaj insulin lossis sulfonylurea raw cov ntaub ntawv), mob pancreatitis, mob raum, mob raum tsis ua haujlwm, mob ntsws tsis zoo, mob plab hnyuv, rhabdomyolysis, thrombocytopenia, bullema thiab kev ua xua (kev ua xua hauv lub cev), syndrome, thiab lwm yam). Sitagliptin posphate monohydrate hmoov yog tsuas yog tawm los ntawm ob lub raum. Rau cov neeg mob uas muaj lub raum tsis zoo rau lub raum tsis txaus, cov koob tshuaj yuav tsum tau hloov kho raws li tus nqi creatinine tshem tawm kom tsis txhob muaj tshuaj ntau ntxiv. Nws yog txwv tsis pub rau cov neeg ua xua rau cov khoom no, cov neeg mob ntshav qab zib hom 1 thiab cov neeg mob ntshav qab zib ketoacidosis. Cov poj niam cev xeeb tub thiab lactation yuav tsum ntsuas qhov zoo thiab qhov tsis zoo ua ntej siv nws

Muaj ntau txoj kev xa khoom rau koj xaiv

Peb lub zog:

Peb lub tuam txhab tau dhau los ntawm FDA thiab ISO19001 kev tswj hwm qhov system ntawv pov thawj. Thiab peb muaj kev koom tes nrog kev cog lus nrog ntau lub Hoobkas thiab chaw kuaj hauv Suav teb, Peb lub tuam txhab tuaj yeem muabSitagliptin Phosphate Monohydrate API Hmoovthiab lwm yam ntawm tus nqi zoo dua. Yog tias koj txaus siab, thov sau ib tsab ntawv.
Peb tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev thauj mus los, tab sis kuj txhawb ntau txoj kev them nyiaj, txawm tias koj siv nyiaj US, euros, Australian las, lossis cov nyiaj hauv zos los ntawm Singapore, Malaysia, Thaib, thiab lwm yam. Peb kuj tuaj yeem txhawb cov txiaj ntsig hauv zos hauv cov cheeb tsam thiab cov tebchaws no. Tsis tas li ntawd, peb kuj txhawb nqa cov npav hauv txhab nyiaj (credit cards, thiab lwm yam) rau kev them nyiaj.

FAQ:

Q1. Yuav khaws li cas?
Nws raug nquahu kom khaws nws kaw, kom deb ntawm lub teeb, thiab noo noo ntawm 2-8 ° C. Nyob rau hauv qhuav thiab kaw, Sitagliptin phosphate monohydrate cov hmoov hmoov feem ntau yuav ruaj khov rau ntau xyoo. Cov tshuaj yuav tsum tau siv sai li sai tau tom qab kev npaj, los yog khov ntawm -20 ° C los yog -80 ° C tom qab ntim.
Q2. Nws stability yog dab tsi?
Sitagliptin phosphate monohydrate API hmoovyog ruaj khov nyob rau hauv cov pa cia tej yam kev mob. Nws cov tshuaj yog ruaj khov nyob rau hauv acidic thiab nruab nrab tej yam kev mob, tab sis nws degrades lub sij hawm nyob rau hauv alkaline tej yam kev mob. Yog li ntawd, muaj zog alkaline ib puag ncig yuav tsum tau zam thaum lub sij hawm tsim khoom thiab tshuaj xyuas cov formulations.
Q3. Dab tsi yog nws lub ntsiab impurities?
Impurities feem ntau muab faib ua ob pawg:
Txheej txheem impurities: intermediates los yog los ntawm - cov khoom tsim tawm thaum lub sij hawm txheej txheem synthesis.
Degradation impurities: oxidation los yog hydrolysis khoom tsim nyob rau hauv lub teeb, kub kub, los yog acid- puag tej yam kev mob.
Ntau yam impurities paub muaj npe nyob rau hauv cov tshuaj pharmacopoeia thiab yuav tsum tau tswj kom zoo thiab kom muaj nuj nqis los ntawm txoj kev xws li HPLC

Tsis lees paub: Cov ntaub ntawv luam tawm ntawm lub vev xaib no los ntawm Is Taws Nem, tsis tau txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm cov ntsiab lus. Thov ua tib zoo saib kom paub qhov txawv. Tsis tas li ntawd, cov khoom muab los ntawm peb lub tuam txhab tsuas yog siv rau kev tshawb fawb tshawb fawb. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.

Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais, thov hu rau peb los ntawmEmail :sales6@faithfulbio.com . Peb pab neeg tau cog lus los ua kom tiav kev txaus siab ntawm cov neeg siv khoom.

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