Tenofovir Disoproxil Powder CAS 201341-05-1

Tenofovir disoproxil yog dab tsi?

Tenofovir disoproxil hmoov, tseem hu ua Tenofovir disoproxil aspartate, tau tsim los ntawm Gilead Sciences. Nws yog dej -soluble diester precursor khoom ntawm cov khoom xyaw nquag tenofovir. Xyoo 2008, FDA tau pom zoo Tenofovir Disoproxil Aspartate rau kev txhim kho kab mob siab B. Nyob rau hauv 2014, nws tau pom zoo los ntawm CFDA rau kev txhim kho kab mob siab B rau cov neeg laus thiab cov me nyuam hnub nyoog 12 xyoo los yog laus dua (nrog ib tug luj ntawm 35 kg los yog ntau tshaj). Vim yog cov yam ntxwv ruaj khov ntawm SRY, nws raug pom zoo los ntawm thoob ntiaj teb cov ntawv pov thawj kev lag luam raws li qhov kev xaiv zoo tshaj plaws rau kev tswj hwm lub cev sab hauv lub cev muaj feem xyuam rau lub siab tsis zoo, nrog kev hloov pauv ruaj khov thiab kev txhawb nqa theoretical.
Nws kuj tseem siv ua ke nrog lwm cov khoom siv tshuaj tiv thaiv kab mob rau kev txhim kho tib neeg kev tiv thaiv kab mob (HIV) ntxeem tau.
Testis-kev txiav txim siab yog ib qho ester precursor khoom ntawm nucleotide thim rov qab transcriptase inhibitor tenofovir, a 5'-monophosphate nucleotide, nrog rau kev cuam tshuam zoo heev nrog cov kab mob loj hlob, uas tuaj yeem cuam tshuam qhov rov qab transcriptase ntawm HIV-1 thiab HIV tus kab mob sib kis{11} los ntawm B thiab B. Tom qab kev tswj hwm qhov ncauj, Tenofovir disoproxil aspartate yog hydrolyzed rau hauv tenofovir, uas yog phosphorylated los ntawm cellular kinases rau hauv pharmacologically active metabolite Tenofovir diphosphate. Lub tom kawg sib tw nrog 5'-triphosphate deoxyadenosine acid thiab koom nrog hauv kev sib txuas ntawm cov kab mob DNA. Tom qab nkag mus rau tus kab mob DNA, vim tsis muaj 3'- pawg hydroxyl, DNA txuas ntxiv raug thaiv, yog li inhibiting kis tus kab mob. Vim nws txoj kev siv tau zoo thiab kev siv ntau npaum li cas, Kev Txhim Kho cov txiaj ntsig yog qhov tseeb, thiab nws yog thawj kab cuam tshuam nrog cov kab mob proliferation khoom pom zoo los ntawm ntau yam kev txhim kho. Tenofovir disoproxil hmoov thiab nws cov kev npaj ua ke tau dhau los ua cov khoom lag luam zoo tshaj plaws los tiv thaiv AIDS tam sim no.

tiv tauj peb ntawm Email :sales6@faithfulbio.com

Dab tsi cuam tshuam nrog pathogen proliferation txoj kev Tenofovir Disoproxil ua raws?

Thaum tenofovir disoproxil muaj cov haujlwm zoo tshaj plaws tiv thaiv tib neeg kev tiv thaiv kab mob (HIV) thiab kab mob siab B (HBV), nws tsis tuaj yeem nqus tau los ntawm txoj hnyuv, yog li nws yuav tsum tau siv los ua cov khoom lag luam hauv kev kho mob. Piv txwv suav nrog Tenofovir disoproxil fumarate , tab sis lwm yam khoom, Tenofovir alafenamide (TAF), muaj zog plasma ntau dua.Tenofovir disoproxil hmoovmuaj cov dej solubility zoo heev thiab sai sai absorbed thiab degraded mus rau hauv lub active tshuaj tenofovir, uas yog ces hloov mus rau hauv lub active metabolite tenofovir bisphosphate. Peak plasma qib ntawm tenofovir tau mus txog 1-2 teev tom qab kev tswj hwm. Bioavailability ntawm tenofovir nce li ntawm 40% thaum noj nrog zaub mov. Tenofovir bisphosphate muaj ib nrab ntawm cov cellular - lub neej ntawm kwv yees li 10 teev, tso cai rau kev tswj hwm ib hnub ib zaug. Vim tias cov khoom no tsis yog metabolized los ntawm CYP450 enzyme system, qhov muaj peev xwm ntawm kev cuam tshuam nrog lwm cov khoom los ntawm cov enzyme no tsawg heev. Nws yog tsuas yog excreted los ntawm glomerular pom thiab active tubular thauj system, nrog kwv yees li 70% mus rau 80% raug tshem tawm tsis hloov pauv hauv cov zis.

 

Lub tswv yim ntawm kev ua ntawm Tenofovir disoproxil tiv thaiv kab mob siab B yog dab tsi?

Tenofovir disoproxil hmoovnws tus kheej yog cov khoom ua ntej uas tsis muaj cov tshuaj pharmacological ncaj qha; nws tsis tam sim ntawd exert nws cov teebmeem tom qab nkag mus rau hauv lub cev. Nws yog thawj zaug tawg thiab metabolized los ntawm hydrolytic enzymes nyob rau hauv lub cev lub hlwb, poob nws dipyridoxine structural pawg thiab maj mam hloov mus rau hauv nruab nrab tenofovir. Tom qab tsim ntawm tenofovir, nws tau dhau los ntawm ob qhov kev cuam tshuam phosphorylation nyob rau hauv catalysis ntawm ntau yam kinases hauv tib neeg lub hlwb, thaum kawg hloov mus rau hauv cov metabolite tseem ceeb nrog lub zog cuam tshuam nrog kev ua haujlwm ntawm cov kab mob proliferation-TENOFOVIR DIPHOSPHATE.

Cov qauv molecular ntawm cov metabolite nquag no zoo ib yam li qhov tshwm sim Deoxyadenosine triphosphate hauv tib neeg lub cev. Ib zaug hauv lub cell, nws sib tw nrog ntuj DATP, nquag vying rau qhov chaw khi ntawm tus kab mob siab B DNA polymerase. Thaum tus kab mob siab B rov ua dua nyob rau hauv lub cev, tus kab mob polymerase yuam kev siv SRY raws li ib txwm raw khoom thiab embeds nws mus rau hauv synthesizing viral DNA saw.

Because Tenofovir Disoproxil, which is >=98% acyclic nucleoside, tsis muaj 3'-hydroxyl pab pawg tsim nyog rau DNA saw txuas ntxiv, ib zaug tso, cov nucleotides tom ntej tsis tuaj yeem txuas tau zoo, ncaj qha ua rau cov synthesis ntawm cov kab mob DNA txuas mus rau qhov nruab nrab. Tus kab mob siab B tsis tuaj yeem ua kom tiav gene replication thiab proliferation, yog li cuam tshuam kev loj hlob ntawm tus kab mob siab B hauv lub cev thiab tswj kev loj hlob ntawm tus kab mob.

MF ntawm Tenofovir disoproxil

Molecular Formula	C19H30N5O10P
Molecular Luj	519.44
Boiling Point	642.7 ± 65.0 degree
Qhov ntom	1.45 ± 0.1 g / cm3 (Kev kwv yees)
Kev cia khoom	Khaws nyob rau hauv qhov tsaus ntuj nti, inert cua, 2-8 degree
Solubility	Dimethyl sulfoxide: Ntau dua lossis sib npaug ntawm 38 mg / mL (73.16 mM)

Specification

Muaj ntau txoj kev xa khoom rau koj xaiv

Peb lub zog:

Peb lub tuam txhab tau dhau los ntawm FDA thiab ISO19001 kev tswj hwm qhov system ntawv pov thawj. Thiab peb muaj kev koom tes nrog kev cog lus nrog ntau lub Hoobkas thiab chaw kuaj hauv Suav teb, Peb lub tuam txhab tuaj yeem muabTenofovir disoproxil hmoovthiab lwm yam ntawm tus nqi zoo dua. Yog tias koj txaus siab, thov sau ib tsab ntawv.
Peb tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev thauj mus los, tab sis kuj txhawb ntau txoj hauv kev them nyiaj, txawm tias koj siv nyiaj US, euros, Australian las, lossis cov nyiaj hauv zos los ntawm Singapore, Malaysia, Thaib, thiab lwm yam. Peb kuj tuaj yeem txhawb cov txiaj ntsig hauv zos hauv cov cheeb tsam thiab cov tebchaws no. Tsis tas li ntawd, peb kuj txhawb nqa cov npav hauv txhab nyiaj (credit cards, thiab lwm yam) rau kev them nyiaj.

FAQ:

Q1: Ntev npaum li cas cov neeg mob kab mob siab B yuav tsum tau noj Tenofovir disoproxil?
Raws li cov ntaub ntawv kho mob uas twb muaj lawm, cov neeg mob feem ntau xav tau kev txhim kho ntev ntev, yuav tsum tau noj SRY kom txog thaum cov antigen nto ploj (tab sis thov nco ntsoov tias qhov tshwm sim ntawm qhov chaw antigen ploj yog tsawg dua 10%). Yog li, cov neeg mob kab mob siab B yuav tsum tau noj cov ntsiav tshuaj TenofivirDisoproxilFumarate rau lub neej, lossis kom txog thaum muaj kev txhim kho zoo dua.
Q2: Dab tsi yuav tsum tau ceev faj thaum siv Tenofovir disoproxil aspartate?
1. Rau cov neeg mob uas muaj lub raum tsis ua haujlwm hnyav, yuav tsum muaj kev ntsuam xyuas ua ntej Kev Txhim Kho. Lub mechanism uasTenofovir disoproxil hmoovkev ua haujlwm feem ntau tshwm sim los ntawm lub raum. Yog li ntawd, cov neeg mob uas lub raum tsis ua hauj lwm tej zaum yuav ua rau ntau tsub zuj zuj ntawm cov khoom nyob rau hauv lub cev, ua rau muaj kev pheej hmoo ntawm kev phiv.
2. Yog tias tus neeg mob tau ntsib cov tsos mob xws li urticaria, ua pob liab liab, lossis ua tsis taus pa, nws qhia tau tias tus neeg mob muaj kev fab tshuaj rau Tenofivir Disoproxil Fumarate lossis cov khoom muaj feem xyuam.
3. Thaum kawg, cov noob qes- qhov kev txiav txim siab tuaj yeem muaj kev cuam tshuam tsis zoo rau tus menyuam hauv plab, xws li kev loj hlob tsis zoo thiab txwv kev loj hlob. Yog li ntawd, cov poj niam cev xeeb tub kuj yuav tsum tsis txhob siv nws.
Q3: Kuv yuav ua li cas yog tias kuv tsis tau koob tshuaj Testis- txiav txim qhov xwm txheej?

Yog tias koj tsis tau txhaj tshuaj Tenofovir Disoproxil Aspartate, thiab cov koob tshuaj tsis tau nyob hauv 12 teev, noj cov tshuaj tam sim ntawd. Yog tias ntau tshaj 12 teev dhau los, hla qhov koob tshuaj no thiab noj cov tshuaj tom ntej li qub; tsis tas yuav noj tshuaj tsis tau lossis muab ob zaug ntxiv.

Nws tso siab rau cov ntshav ruaj khov kom ua tiav qhov pom kev cuam tshuam nrog cov kab mob proliferation ua tau zoo. Kev noj tshuaj tsis tu ncua tuaj yeem ua rau muaj tus kab mob tiv thaiv kab mob. Nws raug nquahu kom txo cov koob tshuaj uas tsis tau txais los ntawm kev siv cov lus ceeb toom ntawm lub xov tooj ntawm tes lossis muab tshuaj rau hauv cov thawv me me. Tsis txhob nce qhov koob tshuaj ntawm koj tus kheej vim tias tsis noj tshuaj, vim qhov no yuav ua rau muaj kev phiv ntau dua.

Tsis lees paub: Cov ntaub ntawv luam tawm ntawm lub vev xaib no los ntawm Is Taws Nem, tsis tau txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm cov ntsiab lus. Thov ua tib zoo saib kom paub qhov txawv. Tsis tas li ntawd, cov khoom muab los ntawm peb lub tuam txhab tsuas yog siv rau kev tshawb fawb tshawb fawb. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.

Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais, thov hu rau peb los ntawmEmail :sales6@faithfulbio.com . Peb pab neeg tau cog lus los ua kom tiav kev txaus siab ntawm cov neeg siv khoom.

Cim npe nrov: Tenofovir disoproxil hmoov cas 201341-05-1, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, kev muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua nyob rau hauv Suav teb