Khoom Taw Qhia
Lub npe tshuaj ntawmValacyclovir hydrochloride hmoovyog: L-valine-2-[(6-oxo-2-amino-1,6-dihydro-9H-purine-9-yl methoxy] ethyl ester hydrochloride. Valacyclovir hydrochloride yog L-valine ester ntawm acyclovir thiab yog ib tug prodrug ntawm acyclovir. Tom qab nkag mus rau hauv lub cev, nws yog tam sim ntawd hydrolyzed rau hauv acyclovir kom nws cov nyhuv tshuaj. Nws yog siv los kho tus kab mob varicella zoster thiab kab mob los ntawm tus kab mob herpes simplex hom I thiab hom II, suav nrog kev kis kab mob hauv qhov chaw mos thiab rov tshwm sim dua.
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| Valacyclovir hydrochloride hmoov Daim duab | Valacyclovir hydrochloride hmoov MF |
Khoom siv
Cov teebmeem ntawmValacyclovir hydrochloride hmoovyog raws li nram no:
Tom qab kev tswj hwm qhov ncauj, valacyclovir hydrochloride hydrate yog hydrolyzed rau hauv acyclovir hauv lub cev. Tom qab acyclovir nkag mus rau hauv cov hlwb uas kis los ntawm tus kab mob herpes, nws sib tw nrog deoxynucleoside rau tus kab mob thymidine kinase lossis cell kinase, thiab cov tshuaj yog phosphorylated rau hauv activated acyclovir triphosphate, uas tom qab ntawd inhibits viral replication nyob rau hauv ob txoj kev: ib qho yog mus cuam tshuam nrog tus kab mob DNA polymerase thiab inhibit. kab mob sib kis; lwm qhov yog khi rau cov saw hlau DNA loj hlob raws li qhov kev txiav txim ntawm DNA polymerase, ua rau kev txuas ntxiv ntawm DNA saw yuav cuam tshuam. Cov tshuaj tiv thaiv kab mob ntawm valacyclovir hydrochloride zoo dua li ntawm acyclovir, thiab nws cov metabolites tsis sib sau hauv lub cev.
1) Ntxiv 81g ntawm dicyclohexylcarbodiimide (DCC), 100g ntawm DMF thiab 54g ntawm acyclovir rau 500ml huv thiab qhuav cov tshuaj tiv thaiv lub raj mis, do kom yaj tag, kub rau 60 degree, ntxiv 10.8g ntawm HOBt thiab 64.8g ntawm CBZ-L-valine nyob rau hauv nplawm, ua kom sov li 2.5 teev, HTLC nrhiav pom cov ntsiab lus acyclovir hauv cov tshuaj tiv thaiv tsawg dua 0.5%, kawg cov tshuaj tiv thaiv, lim kom tshem tawm cov khoom tsim tawm impurities, mloog zoo rau Lim nyob rau hauv qhov txo qis ntawm 60 degree, ntxiv 540g dej, loj hlob muaju ntawm 0 degree rau 2h, lim, thiab qhuav kom tau 91.8g ntawm CBZ-L-valacyclovir.
2) Ntxiv 15 0 g ntawm anhydrous ethanol rau 500 ml huv lub raj mis, ntxiv 46 g ntawm CBZ-L-valacyclovir, 8.1 g ntawm formic acid thiab 2.4 g ntawm sodium formate nrog stirring, ntxiv 2.9 g ntawm palladium. -polyethyleneimine tom qab sib tov, nce qhov kub thiab txias rau 70 degree, ntxiv txog 10.6 g ntawm 0.1 mol hydrochloric acid tov rau cov lim kom kho cov pH tus nqi rau 5.2, maj mam ntxiv txog 94 g ntawm 95% ethanol rau lub raj mis crystallization kom txog thaum nws ua turbid. , loj hlob cov siv lead ua rau 30 min, txuas ntxiv ntxiv dropwise, loj hlob cov siv lead ua rau 1 h, lim, ntxuav lub ncuav mog qab zib lim nrog ib tug tsim nyog tus nqi ntawm 95% ethanol, thiab qhuav kom tau 35.7 g ntawm cov khoom nrog ib tug yield ntawm 77.6%. thiab cov ntsiab lus ntawm cov khoom ntawm 99.2%.
Khoom Specification
| Yam khoom | Specification | Kev tshwm sim |
| Assay | 98% | 99.36% |
| Qhov tshwm sim | Dawb kom tawm hmoov dawb | ua raws |
| tsw | Yam ntxwv | ua raws |
| Saj | Yam ntxwv | ua raws |
| Particle Loj | NLT 100% Los ntawm 80 mesh | ua raws |
| Poob rau ziab | <2.0% | 0.46% |
| Cov hlau hnyav | ||
| Total Heavy Metals | Tsawg dua lossis sib npaug li 10ppm | ua raws |
| Arsenic | Tsawg dua lossis sib npaug li 3ppm | ua raws |
| Coj | Tsawg dua lossis sib npaug li 3ppm | ua raws |
| Kev ntsuam xyuas microbiological | ||
| Tag nrho cov phaj suav | Tsawg dua lossis sib npaug li 1000cfu / g | ua raws |
| Total Poov & Pwm | Tsawg dua lossis sib npaug li 100cfu / g | ua raws |
| E. Coli | Tsis zoo | Tsis zoo |
| Salmonella | Tsis zoo | Tsis zoo |
| Xaus | Ua raws li tus qauv kev lag luam | |
Yuav Ua Li Cas Kom Tau Txais Cov QauvValacyclovir hydrochloride hmoov?
Txais tos xa ib qho kev nug rausunny@faithfulbio.comtxhua lub sijhawm rau tus qauv dawb yog tias koj xav tau APIValacyclovir hydrochloride hmoov.
Qhov zoo tshaj plaws Valacyclovir hydrochloride hmoov Chaw tsim tshuaj paus thiab tsum
Faithfulbio muaj kev paub dhau los hauv kev xa tawm cov ntaub ntawv raw thiab tau tsim kev sib raug zoo thiab kev koom tes ntev nrog peb cov neeg siv khoom. Peb ib txwm muab cov khoom zoo thiab kev pabcuam ua ntej. Yog tias koj muaj cov khoom siv raw khoom xav tau, thov hu rau peb. Peb tuaj yeem lees paub qhov kev txiav txim nrog koj raws li koj qhov yuav khoom ntau. Peb kuj txhawb peb txoj kev koom tes thawj zaug pib los ntawm cov qauv. Tsis tas li ntawd, peb txoj kev thauj mus los sai thiab nyab xeeb kuj ua rau koj tshem tawm cov teeb meem ntawm kev lis kev cai.
Peb muaj kev ntseeg siab ntawm peb cov khoom zoo, tab sis yog tias muaj teeb meem tom qab muag, peb yuav teb sai li sai tau thiab daws lawv nrog koj txoj hauv kev zoo tshaj plaws.
Vim Li Cas Xaiv FaithfulbioValacyclovir hydrochloride hmoov?
Faithfulbio tshwj xeeb hauvValacyclovir hydrochloride hmoovrau ntau xyoo, peb muab cov khoom ntawm tus nqi sib tw, thiab peb cov khoom yog qhov zoo tshaj plaws, vim tias peb nruj heev hauv cov khoom tsim thiab kev sim, thiab muaj kev ua tiav thiab paub tab. Tsis tas li ntawd, peb cov neeg ua haujlwm Cov lus hais rau cov khoom muaj kev sib tw heev.
Muaj ntau txoj kev xa khoom rau koj xaiv
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Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
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3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
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7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
ua siab zoo ceeb toom:SivValacyclovir hydrochloride hmoovrau kev tshawb fawb nkaus xwb. Txhua lub tebchaw muaj kev pheej hmoo. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv. Tsis tas li ntawd, cov lus piav qhia saum toj no ntawm qhov sib xyaw yog los ntawm cov ntaub ntawv online. Yog tias muaj kev ua txhaum cai, thov hu rau peb kom tshem tawm.
Qhov twg Yuav Valacyclovir hydrochloride hmoov?
Cia li xa email rausunny@faithfulbio.com, lossis xa koj qhov yuav tsum tau ua hauv daim ntawv hauv qab, peb muaj kev pabcuam txhua lub sijhawm!
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