Velpatasvir yog dab tsi?
Velpatasvir yog tus tshiab HCV NS5A inhibitor. Velpatasvir is also an inhibitor of SARS-CoV 3CLpro with IC50 of 2.16 μM m..
Velpatasvir yog pan-genotype NS5A inhibitor. Velpatasvir muaj ib tug complex qauv thiab muaj ntau chiral chaw, yog li ntawd cov synthesis yog heev nyuaj, thiab ob peb fragments yuav tsum tau siv rau docking synthesis. Velpatasvir Intermediate A yog qhov tseem ceeb ntawm kev sib txuas ntawm Velpatasvir, uas yog qhov yuav tsum tau ua ua ntej rau kev sib txuas ntawm Velpatasvir.
Velpatasvir hmoovyog cov hmoov dawb lossis dawb zoo li hmoov, thiab cov tshuaj hauv DMSO tuaj yeem khaws cia ntawm -20 C mus txog 3 lub hlis.
| Khoom npe | Velpatasvir |
| CAS | 1377049-84-7 |
| Cov mis mos molecular | C49H54N8O8 |
| Molecular hnyav | 883 |
| EINECS Number | 1592732-453-0 |
| Kev cia khoom | -20 degree |
| Melting point | >170oC (txog) |
| Solubility | Soluble in DMSO(>25 mg/ml) |
| Qhov tshwm sim | Dawb mus rau dawb hmoov |
| Acidity coefficient (pKa) | 1 0.75 ± 0.46 (Tshaj tawm) |
| Qhov ntom | 1.314 ± 0.06 g / cm3 (Tshaj tawm) |
Tus txheej txheem ntawm Velpatasvir hauv kev kho kab mob siab C yog dab tsi?
Velpatasvir hmoovfeem ntau inhibits replication ntawm tus kab mob siab C, yog li txo daim siab mob thiab txo cov kab mob siab C.
Kab mob siab C yog ib hom kab mob siab uas tshwm sim los ntawm tus kab mob siab C, uas yog kab mob sib kis. Velpatasvir yog ib qho tshuaj tiv thaiv kab mob, uas tuaj yeem siv los kho tus kab mob siab C, yog li txo qhov muaj peev xwm rov ua dua ntawm tus kab mob siab C thiab txo cov ntsiab lus ntawm tus kab mob siab C hauv lub cev, thiab muaj qee yam cuam tshuam rau kev tshem tawm tus kab mob siab C.
Khoom Specification
| Yam khoom | Specification | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb rau tan los yog faint yellow khoom | Cov tawv daj daj |
| Kev txheeb xyuas | Los ntawm IR | Ua raws |
| Los ntawm HPLC | Ua raws | |
| Solubility | Dawb soluble hauv ethanol thiab acetone | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug rau 5.00% | 2.10% |
| Hnyav Hlau | Tsawg dua lossis sib npaug li 20ppm | Ua raws |
| Residual Solvents | Ethanol Tsawg dua lossis sib npaug li 5000ppm | 3000 ppm |
| Yam khoom muaj feem | Ib qho impurity: Tsawg dua lossis sib npaug rau 0.50% | 0.12% |
| Tag nrho cov impurities: Tsawg dua lossis sib npaug rau 1.00% | 0.50% | |
| Assay | 47.5% ~ 55.0% ntawm Velpatasvir raws li hauv paus (1: 1) | 49.30% |
| Xaus: | Ua raws li USP Standard | |
Velpatasvir siv rau qhov twg?
1. Velpatasvir yog NS5A inhibitor rau cov neeg mob uas muaj kab mob siab C (HCV).
2. Velpatasvir yog ib tug pan-genotype NS5A inhibitor.
3. Nws tuaj yeem siv los kho cov neeg laus uas muaj tus kab mob siab C gene 1 ~ 6, thiab tsuas yog siv tau rau cov neeg mob uas tsis muaj cirrhosis lossis nyiaj them rov qab, thiab tseem tuaj yeem siv ua ke nrog ribavirin los kho cov neeg mob decompensated cirrhosis.
4. Velpatasvir yog tus thib ob tiam NS5A inhibitor, uas muaj cov tshuaj tiv thaiv kab mob zoo hauv vitro tiv thaiv tag nrho cov genotypes ntawm HCV thiab ntau NS5A kev hloov pauv thiab tshuaj tiv thaiv kev hloov pauv.
HTML5 atlas of Velpatasvir
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Qhov txawv ntawm Velpatasvir thiab Sofosbuvir yog dab tsi?
Kab mob siab C yog tshwm sim los ntawm tus kab mob siab C, uas yog kis tau los ntawm cov ntshav, kev sib deev, niam-rau-tus menyuam thiab lwm txoj hauv kev. Cov tshuaj tiv thaiv kab mob xws li Sofosbuvir thiab Velpatasvir tuaj yeem siv rau kev kho mob, uas tuaj yeem cuam tshuam kev rov ua dua ntawm tus kab mob siab C, yog li ua tiav cov txiaj ntsig kho. Sofosbuvir thiab Velpatasvir yog ob qho tib si tshuaj rau kev kho tus kab mob siab C, tab sis vim yog cov txheej txheem sib txawv ntawm cov tshuaj, cov kev kho mob kuj txawv. Sofosbuvir ua tiav cov txiaj ntsig kho mob feem ntau los ntawm inhibiting tus kab mob rov ua dua tshiab los ntawm daim siab hlwb. Velpatasvir inhibits qhov rov ua dua ntawm tus kab mob siab C los ntawm kev ua rau rov qab transcriptase ntawm tus kab mob siab C, thiab ob leeg tuaj yeem siv los kho tus kab mob siab C.
Velpatasvir configuration daws concentration siv:
| 1mg ib | 5mg ib | 10mg ib | |
| 1 mM | 1, 132ml | 5 ,662ml | 11, 325 ml |
| 5 mM | 0.226 ml | 1, 132ml | 2, 265ml |
| 10 mM | 0.113 ml | 0.566 ml | 1, 132ml |
| 5 mM | 0.023 ml | 0.113 ml | 0.226 ml |
Dab tsi yog kev ceev faj rau kev siv Velpatasvir hmoov?
1. Cov neeg tsis tuaj yeem noj tau: Rau cov neeg mob uas muaj kev tsis haum tshuaj, cov khoom xyaw tshuaj yuav tsum tau kuaj xyuas ua ntej noj nws kom tsis txhob muaj kev phiv. Cov poj niam cev xeeb tub yuav tsum tsis txhob siv cov tshuaj no, vim tias nws tuaj yeem cuam tshuam kev loj hlob ntawm tus menyuam hauv plab.
2. Kev noj tshuaj: Cov neeg mob yuav tsum siv tshuaj raws li cov kws kho mob tau sau tseg, thiab qhov ntau npaum li cas yuav tsum tsis txhob nce lossis txo qis ntawm qhov xav tau. Nws yog qhov zoo tshaj rau noj nws nyob rau tib lub sijhawm los xyuas kom meej qhov ruaj khov thiab cov nyhuv ntawm cov tshuaj.
3. Taboo cov zaub mov: Thaum noj, cov neeg mob yuav tsum tau xyuam xim rau kev noj zaub mov, noj cov zaub mov tsis zoo, xws li barbecue, kib, ntsim, thiab lwm yam, thiab tsis txhob haus dej haus cawv xws li cawv thiab kas fes kom tsis txhob ua rau muaj kev phiv tshuaj. .
Yuav ua li cas thiab qhov twg yuav Velpatasvir Powder wholesale?
Koj tuaj yeem tso siab rau peb qhov kev txiav txim vim tias peb muaj cov ntaub ntawv zoo ntawm kev muag tshuaj raws cai.
Peb ua qhov kev kuaj xyuas ywj pheej ntawm txhua yam khoom thiab tom qab ntawd muag rau peb cov neeg siv khoom hwm.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Muaj ntau txoj kev xa khoom rau koj xaiv
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Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
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3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
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7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Tsis lees paub: Cov ntawv luam tawm ntawm lub xaib no yog siv los txhawb kev sib pauv kev kawm thiab kev kawm, thiab tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov lim kom zoo. Yog tias koj ntseeg tias tsab xov xwm no ua txhaum, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.
Nco tseg: Cov tshuaj no yuav tsum tau siv rau kev tshawb fawb nkaus xwb. Cov lus thov no tsis tau raug soj ntsuam los ntawm Food and Drug Administration. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv lawv. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho, lossis tiv thaiv txhua yam kab mob.
Cim npe nrov: velpatasvir hmoov cas 1377049-84-7, Suav teb, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, kev muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua nyob rau hauv Tuam Tshoj