Zafirlukast hmoov CAS 107753-78-6

Zafirlukastyog triene receptor antagonist ntawm hypersensitive qeeb reacting tshuaj xws li LTC4, LTD4 thiab LTE4, uas yog ib qho kev sib tw inhibitor thiab xaiv tau zoo, thiab tuaj yeem tiv thaiv qhov nce ntawm vascular permeability, tracheal edema thiab eosinophilic infiltration los ntawm leukotriene peptides.

Zafirlukastyog ib qho kev ua yeeb yam ntev thiab muaj kev xaiv cysteylleukotriene (lys-LTs) receptor antagonist, thiab leukotrienes ua lub luag haujlwm tseem ceeb hauv kev mob ntsws asthma. Cov tshuaj no yog tag nrho cov polypeptides, uas tuaj yeem xaiv khi rau LTC4, LTD4 thiab LTE4 receptors los tiv thaiv lawv cov teebmeem, txo cov tsos mob ntsig txog mob hawb pob thiab txhim kho lub ntsws ua haujlwm. Cov khoom no yog ob qho tib si prophylactic rau o los ntawm mob hawb pob (antagonizing pro-inflammatory kev ua ntawm leukotrienes) thiab ib tug reliever rau bronchial dilation thaum mob hawb pob (antagonizing bronchial du nqaij contraction los ntawm leukotrienes). Kev siv cov khoom no tsis hloov cov leeg nqaij zoo rau 2 receptor, thiab muaj txiaj ntsig zoo ntawm bronchoconstrictive spasm tshwm sim los ntawm antigen, tshuaj aspirin, kev tawm dag zog thiab cua txias, thiab tuaj yeem txo cov tshuaj hormones thiab 2 receptor agonists.

Zarlukasyog soj ntsuam rau kev tiv thaiv thiab kev kho mob ntawm mob me me mus rau nruab nrab hawb pob, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas rhiab heev rau cov tshuaj aspirin los yog muaj cov tshuaj aspirin, los yog muaj kab mob ua pa (xws li qhov ntswg polyps, allergic rhinitis); Nws yuav tsum tsis txhob siv los kho mob hawb pob. Kev kho cov tshuaj hormone-resistant asthma lossis asthma cov neeg mob uas tsis kam siv cov tshuaj hormones. Zarlukas yog siv rau mob hawb pob hnyav los tswj kev mob hawb pob lossis txo qis kev siv tshuaj hormones.