6-Diazo-5-oxo-L-norleucineyog cov dej-soluble daj daj hmoov (dawb daim ntawv siv lead ua yog daj-ntsuab koob) soluble nyob rau hauv methanol, acetone los yog ethanol, tab sis nws yog ib qho nyuaj rau yaj nyob rau hauv anhydrous cawv. Hauv phosphate buffer nrog pH 7, qhov siab tshaj plaws ultraviolet nqus yog 274 nm (E1% 1 cm. 683) thiab 244 nm (E1% 1 cm 376). Hauv 0.9% NaCl, qhov kev daws ntawm tsawg kawg yog 50 μM DON yog daj ntseg daj. Raws li cov tshuaj tua kab mob cais tawm ntawm Streptomyces, nws muaj cov tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob. Nws cov khoom lag luam ua ntej yog JHU-083, ib qho kev sim khoom raws li glutaminase inhibitor.
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| 6-DIAZO-5-OXO-L-NORLEUCINE CAS 157-03-9 | 6-Diazo-5-oxo-L-nor-Leucine MF:C6H9N3O3 |
JHU -083 yog dab tsi?
JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) yog ib yam khoom tshiab ua ntej rau DON. Nws belongs rau cov khoom sim ntawm glutamine enzyme inhibitor thiab tseem tsis tau tsim tawm ntau, yog li nws yuav tsum tau npaj thiab siv rau ntawm qhov chaw. Raws li cov kev tshawb fawb tshawb fawb tshiab, peb pom tias nws tuaj yeem nkag mus rau hauv daim ntawv nquag6-Diazo-5-oxo-l-norleucineHauv cov nas, xaiv thaiv cov haujlwm ntawm glutaminase hauv hlwb CD11b + cell. Hauv kev sib piv ntawm cov qauv kev coj tus tsiaj, peb pom tias ua ntej siv cov khoom no, cov tsiaj tau nthuav tawm ib tus cwj pwm nyob ib leeg thiab kev nyuaj siab (xws li feem ntau ntsia blankly nyob rau hauv qhov chaw nqaim, thiab nquag tsoo phab ntsa nrog koj lub taub hau.) thiab muaj zog aggression (xws li kev tawm tsam. lawv cov phooj ywg thiab cov neeg saib xyuas), uas zoo ib yam li kev paub zoo txog kev puas siab puas ntsws bipolar. Tom qab siv cov khoom no, cov tsiaj muaj kev coj tus cwj pwm tsis zoo thiab kev sib raug zoo, thiab lawv tus cwj pwm ua phem yuav tsawg thiab tsis tshua muaj. Raws li qhov ntau ntawm cov ntaub ntawv sib piv, peb ntseeg tias JHU-083 muaj peev xwm txhim kho kev nyuaj siab ntsig txog tus cwj pwm tshwm sim los ntawm kev mob ntev.
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| 1998725-11-3 JHU-083 MF:C14H24N4O4 | Kev puas siab puas ntsws bipolar (kev puas siab puas ntsws). |
kev nyuaj siab ntxhov plawv.JHU-083 thiab 6-DIAZO-5-OXO-L-NORLUCINE yog cov khoom tsim tshiab ntawm peb lub tuam txhab. Yog hais tias koj xav nyob rau hauv lawv, thov sau ntawv rau peb los ntawmemail: sales6@faithfulbio.com.
Cov tshuaj pharmacological ntawm cov khoom no yog dab tsi?
6-Diazo-5-oxo-L-norleucine(DON) yog glutamine antagonist, thiab vim nws qhov zoo sib xws rau glutamine, nws kuj yog cytotoxic inhibitor ntawm ntau yam nucleotide synthases. Hauv xyoo 2019, kev tshawb fawb tsiaj tau pom tias thaum ua ke nrog cov calorie txwv tsis pub noj ketogenic, DON tuaj yeem tua cov qog hlwb, cov tsos mob rov qab, thiab txhim kho tag nrho cov ciaj sia nyob hauv cov nas nrog kev sim siab glioblastoma. Txawm li cas los xij, nws yuav tsum tau muab sau tseg tias DON tseem tsis tau pom zoo ua tshuaj lossis raug rau cov khoom lag luam kom ntxaws ntxiv. Peb tsuas tuaj yeem xav tias DON nkag mus rau hauv cov chaw catalytic ntawm cov enzymes los ntawm nws cov qauv glutamine zoo sib xws thiab inhibits lawv los ntawm covalent khi (los yog ntau dua, los ntawm alkylation).
Muaj ntau txoj kev xa khoom rau koj xaiv
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Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
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3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
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7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Peb lub zog:
Peb lub tuam txhab tau dhau los ntawm FDA thiab ISO19001 kev tswj hwm qhov system ntawv pov thawj. Thiab peb muaj kev koom tes nrog kev pom zoo nrog ntau lub chaw tsim khoom thiab chaw soj nstuam hauv Suav teb, Yog li ntawd, peb tuaj yeem tsis tsuas yog tau txais cov khoom siv tshawb fawb tshiab tshiab nrog tus nqi qis thiab zoo los ntawm lwm txoj hauv kev, xws liJHU-083 thiab L-6-Diazo-5-oxonorleucine, tab sis kuj lees txais koj qhov kev tso siab kom tau txais lwm yam khoom siv txuj ci thiab thev naus laus zis uas koj nyiam.
Peb tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev thauj mus los, tab sis kuj txhawb ntau txoj hauv kev them nyiaj, txawm tias koj siv nyiaj US, euros, Australian las, lossis cov nyiaj hauv zos los ntawm Singapore, Malaysia, Thaib, thiab lwm yam. Peb kuj tuaj yeem txhawb cov txiaj ntsig hauv zos hauv cov cheeb tsam thiab cov tebchaws no. Tsis tas li ntawd, peb kuj txhawb nqa cov npav hauv txhab nyiaj (credit cards, thiab lwm yam) rau kev them nyiaj.
Tsis lees paub: Cov ntaub ntawv luam tawm ntawm lub vev xaib no los ntawm Is Taws Nem, tsis tau txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm cov ntsiab lus. Thov ua tib zoo saib kom paub qhov txawv. Tsis tas li ntawd, cov khoom muab los ntawm peb lub tuam txhab tsuas yog siv rau kev tshawb fawb tshawb fawb. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.
Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais, thov hu rau peb los ntawmEmail :sales6@faithfulbio.com . Peb pab neeg tau cog lus los ua kom tiav kev txaus siab ntawm cov neeg siv khoom.
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