Puas tuaj yeem kho mob qog noj ntshav prostate los ntawm kev noj Darolutamide?

Xyoo 2020, nws kwv yees tias 1.4 lab tus txiv neej yuav raug kuaj mob qog noj ntshav, thiab kwv yees li 375,000 cov neeg thoob ntiaj teb yuav tuag los ntawm prostate. Nws tau ob xyoos tam sim no, thiab nrog kev loj hlob ntxiv ntawm cov pej xeem thoob ntiaj teb, peb muaj laj thawj ntseeg tias cov pab pawg no yuav nce ntxiv.
Thaum lub sijhawm kuaj mob, cov txiv neej feem ntau muaj mob qog noj ntshav hauv zos, uas txhais tau hais tias lawv cov qog nqaij hlav nyob hauv prostate thiab tuaj yeem kho tau los ntawm kev phais radical lossis radiotherapy.
Thaum tus kab mob rov tshwm sim, nws yuav hloov lossis kis mus. Androgen deprivation therapy (ADT) yog lub hauv paus ntawm kev kho cov kab mob rhiab heev. Cov txiv neej uas muaj metastatic hormone-rhiab heev prostate cancer (HSPC) yuav pib kho cov tshuaj hormones, xws li ADT, ARi ua ke nrog ADT lossis docetaxel ua ke nrog ADT.
Txawm tias tom qab tau txais kev kho mob thawj zaug uas tau hais los saum toj no, feem ntau cov neeg mob mHSPC yuav nce mus rau mCRPC, thiab lawv txoj sia nyob thiab kev ua neej zoo yuav raug cuam tshuam loj heev.

Dab tsi tshuaj yog dalotamide?

Dalotamide raw khoom yog ib qho androgen receptor inhibitor (ARi). Nws cov qauv tshuaj tshwj xeeb muaj kev sib raug zoo rau cov receptor thiab qhia tau hais tias muaj zog antagonistic kev ua, yog li inhibiting kev ua haujlwm ntawm receptor thiab kev loj hlob ntawm prostate cancer hlwb. Txhawm rau txo qis kev loj hlob ntawm cov qog nqaij hlav qog nqaij hlav prostate hauv vitro thiab cov qog ntim ntawm cov qog nqaij hlav qog nqaij hlav prostate. Nws yog tsim nyog rau kev kho mob ntawm non-metastatic castration-resistant prostate cancer nrog siab metastasis, thiab tag nrho cov ciaj sia taus ntawm cov neeg mob siv cov khoom no nyob rau hauv lub tsev kho mob tau zoo heev. Cov tshuaj tseem siv tau rau hauv theem III ARASENS kuaj rau kev kho mob metastatic hormone-sensitive prostate cancer.

Dab tsi yog pharmacological kev txiav txim ntawm dalotamide?

Thaum Lub Xya Hli 30, 2019, US Food and Drug Administration (FDA) tau pom zoo tso tawm cov tshuaj tiv thaiv kab mob qhov ncauj tshiab, Nubeqa (daruramide), rau kev kho mob ntawm cov neeg mob uas tsis yog-metastatic castration-tolerant prostate cancer (nmCRPC). Nws yog ib qho tshuaj tiv thaiv kab mob monoclonal thiab tuaj yeem lees paub thiab ua ke nrog HER2 receptor los tsim ib qho nyuaj. HER2 receptor yog ib tug tswv cuab ntawm tib neeg epidermal growth factor receptor (EGFR) tsev neeg, uas koom nrog hauv kev tswj hwm ntawm cell loj hlob, sib txawv thiab ciaj sia nyob rau hauv lub cev ib txwm muaj. Txawm li cas los xij, hauv qee cov neeg mob qog noj ntshav thiab mob qog noj ntshav, kev qhia ntawm HER2 receptor siab dhau lawm, uas ua rau muaj kev loj hlob, cuam tshuam thiab metastasis ntawm cov qog nqaij hlav cancer. Dalotamide ntsiav tshuaj tuaj yeem thaiv cov teeb liab hloov ntawm HER2 receptor, yog li inhibiting kev loj hlob thiab kev faib tawm ntawm cov qog nqaij hlav cancer.

Peb yuav tsum ua li cas thiaj raug kev txom nyem?

Vim muaj kev vam meej tas mus li thiab kev txhim kho ntawm kev kho mob thev naus laus zis, yuav muaj ntau thiab ntau hom tshuaj uas tuaj yeem siv rau cov kab mob cuam tshuam. Ntev npaum li cov neeg mob nkag siab meej txog cov kev kho mob yooj yim, nrhiav cov qauv kev kho kom raug, ua raws li tus kws kho mob cov cai thiab cov kauj ruam dhau los, lawv yuav daws qhov teeb meem. Txawm li cas los xij, hauv kev mob qog nqaij hlav prostate, qhov kev tsom xam feem ntau yog metastasized thiab kis tau, thiab cov qog tuaj yeem metastasize thiab rhuav tshem lwm cov ntaub so ntswg lossis cov khoom hauv nruab nrog cev. Cov neeg mob uas mob qog nqaij hlav prostate siab heev muaj tus nqi kho mob tsawg, lub sij hawm muaj sia nyob luv luv thiab ob peb txoj kev kho mob. Lub sijhawm no, txawm tias lawv nquag noj dalotamide, lawv tsis tuaj yeem kho tau, tab sis nws tuaj yeem ua rau lub sijhawm muaj sia nyob ntawm cov neeg mob, txo lawv cov tsos mob thiab txhim kho lawv lub neej kom zoo. Qhov no yuav tsum yog lub hnub ci ntsa iab.

Cov ntaub ntawv hauv kab lus no yog los ntawm Is Taws Nem thiab tsis siv los ua cov lus qhia txog kev kho mob lossis cov lus qhia peev. Yog tias tsab xov xwm no muaj kev cuam tshuam rau koj txoj cai thiab kev txaus siab lossis xav paub txog cov khoom no, thov hu rau peb raws sijhawm kom peb tuaj yeem muab kev pab ntxiv rau koj