Mob ntshav qab zib neuropathyyog ib qho teeb meem loj tshaj plaws rau cov neeg mob ntshav qab zib mellitus. Mob ntshav qab zib neuropathy hais txog ntau hom paj hlwb puas cuam tshuam nrog ntshav qab zib mellitus. Cov tsos mob nyob ntawm qhov chaw ntawm cov hlab ntsha puas thiab tuaj yeem suav nrog kev hloov lub cev muaj zog xws li tsis muaj zog; hnov cov tsos mob xws li loog, tingling, los yog mob; los yog autonomic hloov xws li cov tsos mob tso zis. Cov kev hloov pauv no tau xav tias yog los ntawm kev raug mob microvascular uas muaj cov hlab ntsha me uas muab cov hlab ntsha (vasa nervorum). Cov xwm txheej zoo sib xws uas tuaj yeem cuam tshuam nrog ntshav qab zib neuropathy suav nrog distal symmetric polyneuropathy; thib peb, plaub, lossis thib rau cranial paj hlwb; mononeuropathy; mononeuropathy multiplex; ntshav qab zib amyotrophy; thiab autonomic neuropathy.
Lub hauv paus theoretical thiab cov yam ntxwv ntawm epalrestat
Epalrestatyog ib qho carboxylic acid derivative thiab tsis muaj kev sib tw thiab thim rov qab aldose reductase inhibitor siv rau kev kho mob ntshav qab zib neuropathy, Nws txo cov tsub zuj zuj ntawm intracellular.sorbitoluas ntseeg tau tias yog qhov ua rau mob ntshav qab zib neuropathy, retinopathy, thiab nephropathy Nws tau txais txiaj ntsig zoo, nrog rau feem ntau tshaj tawm cov kev tsis zoo yog cov teeb meem hauv plab hnyuv xws li xeev siab thiab ntuav, nrog rau kev nce hauv qee lub siab enzymes. Chemically, epalrestat yog txawv nyob rau hauv uas nws yog ib qho tshuaj uas muaj ib pawg rhodanine. Aldose reductase yog qhov tseem ceeb enzyme nyob rau hauv txoj kev polyol uas nws txhim kho kev ua haujlwm yog lub hauv paus ntawm ntshav qab zib neuropathy. Aldose reductase inhibitors (ARI) tsom rau cov enzyme no. Ntawm ntau ARIs tsim,Epalrestattsuas yog kev lag luam pom zoo ARI. Nws yog yooj yim absorbed los ntawm paj hlwb thiab inhibits enzymes nrog tsawg heev phiv.
sorbitol yog dab tsi thiab nws cov nqi kho mob yog dab tsi?
Sorbitol tsis tshua muaj npe hu uaglucitolyog ib tug qab zib cawv nrog ib tug qab zib saj uas tib neeg lub cev metabolizes maj mam. Nws tuaj yeem tau txais los ntawm kev txo cov piam thaj, uas hloov pauv aldehyde pawg (−CHO) mus rau thawj pawg cawv (−CH2OH). Feem ntau sorbitol yog tsim los ntawm qos yaj ywm starch, tab sis nws kuj muaj nyob rau hauv cov xwm, piv txwv li nyob rau hauv txiv apples, pears, txiv duaj, thiab prunes. Raws li ib qho tshuaj tom khw muag khoom, sorbitol yog siv los ua laxative los kho cem quav. Sorbitol yog fermented nyob rau hauv txoj hnyuv thiab tsim cov kab mob luv luv fatty acids, uas muaj txiaj ntsig zoo rau tag nrho txoj hnyuv loj. Tib lub sijhawm, sorbitol tov nrog 69-71 feem pua cov ntsiab lus feem ntau yog siv hauv kev lag luam khoom noj. Nws yog ib qho tseem ceeb heev cov khoom qab zib, humectant, chelating agent, thiab stabilizer, thiab yuav tsis ua rau cov hniav caries thaum siv. Nyob rau tib lub sijhawm, nws yog siv los ua cov khoom siv raw rau kev tsim cov vitamin C. Sorbitol tuaj yeem tsim los ntawm fermentation thiab tshuaj synthesis. Nws kuj tseem tuaj yeem siv los ua cov khoom siv raw rau kev lag luam surfactants, thiab nws tuaj yeem siv los tsim Span thiab Tween surfactants. Nws tseem yog ib qho tseem ceeb raw khoom rau roj chromatography nyob ruaj ruaj kua thiab diuretic dehydrating agents, thiab nws yog ib qho khoom siv dav.
Ntshav qab zib neuropathy suav nrog dab tsi? Vim li cas sorbitol yog tus yuam sij!
Mob ntshav qab zib neuropathy yog ib qho ntawm cov teeb meem mob ntshav qab zib mellitus, uas tuaj yeem suav nrog cov hauv qab no:
Ua ntej, distal symmetrical sensorimotor polyneuropathy kuj yog hom mob ntshav qab zib peripheral neuropathy. Cov tsos mob feem ntau pib los ntawm qhov kawg ntawm qhov kawg ntawm lub caj dab, thiab maj mam nce mus rau hauv lub hnab looj tes zoo li thiab thom khwm zoo li kev faib tawm mus rau qhov kawg. Feem ntau, kev puas siab puas ntsws feem ntau pib los ntawm cov ceg qis, nrog rau cov tsos mob ntawm lub paj hlwb sib txawv, thiab dyskinesia yog qhov mob me;
Thib ob, autonomic neuropathy, autonomic neuropathy tsis tshua tshwm sim ib leeg, feem ntau nrog rau kev mob hlwb, uas tuaj yeem tshwm sim hauv cov hlab plawv, kab mob plab, kab mob genitourinary, kab mob zais zis, thiab tawm hws txawv txav;
Thib peb, mob mob neuropathy, uas tsis tshua muaj;
Plaub, cov kev hloov pauv pathological ntawm cov hlab ntsha cranial, feem ntau yog cov hlab ntsha oculomotor tuag tes tuag taw.
Aldose reductase yog thawj enzyme nyob rau hauv txoj kev sorbitol-aldose reductase lub luag haujlwm rau kev txo cov piam thaj rau sorbitol, nrog rau kev txo qis ntawm galactose rau galactitol. sorbitol ntau dhau nyob rau hauv cov hlwb retinal, cov hlwb ntawm lub lens, thiab Schwann hlwb uas myelinate peripheral qab haus huv, yog ib qho tshwm sim ntawm cov hyperglycemia mus sij hawm ntev uas nrog rau kev tswj tsis tau cov ntshav qab zib. Qhov no tuaj yeem ua rau cov hlwb puas, ua rau retinopathy, cataracts, thiab peripheral neuropathy, feem.
Kab lus no yog los ntawm Is Taws Nem thiab tsis muab cov lus qhia muaj txiaj ntsig. Yog tias koj muaj lus tsis txaus siab rau tsab xov xwm no, thov hu rau peb raws sijhawm. Ua tsaug