Mob ntshav qab zibyog ib hom kab mob sib kis. Nws feem ntau tshwm sim los ntawm kev nce qib ntawm cov piam thaj hauv cov ntshav. Tus neeg mob yuav muaj kev nqhis dej ntau dhau, thiab haus dej ntau dhau. Nws yog ib qho tsim nyog yuav tsum tau koom tes nrog tus kws kho mob kom txo cov ntshav qab zib hauv lub cev mus rau tus nqi ib txwm los ntawm kev siv tshuaj hypoglycemic ntawm qhov ncauj lossis txhaj tshuaj insulin. Yog tias nws tsis tswj tau raws sijhawm, nws yuav ua rau dig muag lossis lub raum tsis ua haujlwm.
Dab tsi yog glucagon-zoo li peptide -1?
Glucagon zoo li peptide -1yog ib tug ntau yam peptide hormone secreted los ntawm L hlwb ntawm ileum thiab txoj hnyuv, teej tug mus rau incretin. Nws yog tsuas yog siv los kho mob ntshav qab zib hom 2. Nws tuaj yeem tswj tsis tau lub cev cov piam thaj kom cov ntshav qab zib hauv lub cev ruaj khov,
Raws li ib tug inhibitor,GLP-1tuaj yeem txhawb kev tso tawm ntawm insulin thiab inhibit qhov tso tawm ntawm glucagon los ntawm pancreas thaum cov ntshav qabzib concentration hauv lub cev siab, thiaj li ua tiav lub hom phiaj ntawm kev txo cov ntshav qabzib. Thaum cov piam thaj hauv cov ntshav poob mus rau qhov qub, nws yuav tsis tsim cov tshuaj insulin. Yog li ntawd, hypoglycemia yuav tsis tshwm sim tom qab noj tshuaj, thiab tus neeg mob cov ntshav qabzib tuaj yeem khaws cia hauv lub xeev txias thiab ruaj khov, tib lub sijhawm, nws tuaj yeem ua lub luag haujlwm tiv thaiv kab mob plawv.
Glucagon-zoo li peptide-1 receptor agonist (GLP-1RA) yog ib hom tshuaj hypoglycemic tshiab hauv xyoo tas los no. Los ntawm kev ua kom lub GLP-1 receptor, nws tuaj yeem txhim kho insulin secretion hauv cov piam thaj hauv cov ntshav, inhibit glucagon secretion, ncua lub plab zom mov, thiab txo cov khoom noj los ntawm kev noj qab haus huv hauv nruab nrab, txhawm rau txo cov ntshav qab zib thiab poob phaus. .
Dab tsi yog qhov txawv ntawm insulin thiab glucagon?
Insulin thiab glucagon yog ob yam tshuaj hormones tseem ceeb uas tswj cov ntshav qab zib. Glucagon thiab insulin muaj qhov sib txawv hauv qab no:
1, Tsis zoo li secreting hlwb, glucagon yog tsim los ntawm pancreas Cell secreted; Cov tshuaj insulin yog tsim los ntawm pancreas Cell secretion belongs rau endocrine kev ua haujlwm ntawm pancreas.
2, Lub luag haujlwm sib txawv: glucagon belongs rau cov tshuaj hormones uas txhawb catabolism, uas tuaj yeem txhawb glycogen decomposition, tswj cov ntshav qabzib concentration, txhawb cov protein thiab rog decomposition, thiab muab cov khoom glutenous; Insulin yog ib hom tshuaj anabolic, uas txhawb cov synthesis ntawm glycogen, protein, thiab rog thiab inhibits decomposition.
3, Insulin tsuas yog cov tshuaj hypoglycemic nkaus xwb hauv lub cev; Glucagon yog ib hom hyperglycemic hormone, thiab cov teebmeem ntawm ob cov tshuaj hormones yog diametrically opposite.
Thaum cov ntshav qab zib nce siab, nws yuav inhibit qhov tso tawm ntawm glucagon thiab txhawb nqa cov tshuaj insulin kom txo cov ntshav qab zib, thiab rov ua dua, txhawm rau tswj cov ntshav qabzib sib npaug.
Kev tsim cov khoom zoo sib xws hauv tsev kho mob
Lub cev ua haujlwm ntawm glucagon-zoo li peptide-1 (GLP-1) suav nrog:
Txhawb nqa pancreas thiab islets - Insulin secretion ntawm cov hlwb
Inhibition ntawm pancreatic islets - Glucagon secretion ntawm cov hlwb
Inhibit gastric motility thiab ncua lub plab khoob
Los ntawm lub hauv paus paj hlwb, GLP-1 tuaj yeem txo qis qab los noj mov
Qhov tshwj xeeb physiological muaj nuj nqi ntawm GLP-1 muaj txiaj ntsig zoo rau kev kho mob ntshav qab zib, thiab nws yog ib qho kev tshawb fawb kub hauv ntshav qab zib. Vim tias GLP-1 yooj yim degraded los ntawm dipeptidyl peptidase-4 (DPPIV) hauv cov ntshav, nws ib nrab-lub neej (T1 / 2) tsuas yog ob peb feeb xwb.
Cov tswv yim tsim tshuaj muaj xws li dipeptidyl peptidase-4 inhibitors thiab GLP-1 analogs.
Muaj ntau cov tshuaj GLP-1 nyob rau hauv lub khw tam sim no, uas yuav yog qhov kev loj hlob tshiab rau cov tshuaj ntshav qab zib hauv 10 xyoo tom ntej. Tam sim no, plaub GLP-1 receptor agonists tau pom zoo los ntawm CFDA kom tau teev tseg, suav nrogExenatide, Liraglutide, thiabLixisenatide. DulaglutidethiabSemaglutidemuaj nyob rau hauv kev ua lag luam daim ntawv thov, thiabAlbiglutideyog nyob rau hauv kev sim tshuaj.
Lub tuam txhab tuaj yeem muab cov khoom muaj feem xyuam. Yog tias koj txaus siab, thov hu rau peb raws sijhawm
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