Pregabalinbelongs rau tsis yog - - GABA receptor agonist lossis antagonist ib yam tshiab ntawm calcium channel regulator, uas tuaj yeem thaiv cov kab hluav taws xob-nyob ntawm calcium thiab txo cov kev tso tawm ntawm cov neurotransmitters. Clinically, nws yog tsuas yog siv rau neuralgia ntsig txog mob ntshav qab zib peripheral neuropathy, post-herpetic neuralgia, thiab kev kho mob ntawm cov neeg laus ib nrab qaug dab peg, kev ntxhov siab ntau, thiab hauv nruab nrab neuralgia (xws li neuralgia cuam tshuam nrog kev raug mob qaum qaum, mob stroke, thiab ntau yam sclerosis), thiab fibromyalgia.
Kev faib tawm peb-kauj ruam ntawm cov tshuaj tua kab mob
Kev faib tawm ntawm cov tshuaj tua kab mob peb-kauj ruam yuav tsum xaiv cov tshuaj nrog cov kauj ruam sib xws rau qhov mob me me, mob me me, mob hnyav thiab tsis tu ncua. Raws li xyoo ntawm kev hloov kho thiab kev txhim kho, txoj kev tshuaj loog no tsis yog siv rau kev tswj kev mob qog noj ntshav xwb, tab sis kuj tseem siv rau ntau yam kab mob, xws li mob thiab mob ntev uas tsis yog mob qog noj ntshav los ntawm cov kab mob degenerative, kab mob musculoskeletal, mob neuropathic. mob thiab lwm yam mob ntev.
1. Thawj theem: feem ntau yog mob me me, feem ntau yog cov tshuaj uas tsis yog opioid, xws li cov tshuaj uas tsis yog steroidal anti-inflammatory, ibuprofen, tshuaj aspirin, thiab lwm yam, thiab cov tshuaj acetanilide, xws li paracetamol, nrog lossis tsis muaj adjuvants;
2. Qhov thib ob theem: feem ntau yog mob me me, siv cov tshuaj tsis muaj zog opioids, xws li dihydrocodeine thiab tramadol, nrog lossis tsis muaj cov tshuaj opioids, nrog lossis tsis muaj adjuvants;
3. Qhov thib peb theem: feem ntau yog rau qhov mob hnyav thiab tsis tu ncua, siv cov tshuaj opioids uas muaj zog dua, xws li morphine, methadone, fentanyl, oxycodone, thiab buprenorphine, nrog lossis tsis muaj opioids, nrog lossis tsis muaj adjuvants.
Adjuvants tseem hu ua kev sib xyaw ua ke analgesics. Txawm hais tias lawv feem ntau yog siv los qhia lwm yam tsis yog kev kho mob, cov tshuaj no muaj kev pab tshwj xeeb hauv ntau yam mob. Adjuvants muaj xws li tshuaj tiv thaiv kev nyuaj siab, xws li serotonin, norepinephrine reuptake inhibitors, anticonvulsants, xws li tshuaj loog hauv zos (lidocaine), corticosteroids, bisphosphonates, thiab lwm yam.
Muaj pes tsawg qib ntawm cov tshuaj tua kab mob yog pregabalin
Pregabalin yog kev kho mob raws li ib tug 2-3 analgesic. Pregabalin yog ib qho tshuaj tiv thaiv kab mob thiab cov tshuaj calcium channel tshiab. Nws yog siv los kho cov mob neuropathic, tshwj xeeb tshaj yog herpes zoster neuralgia, me me trigeminal neuralgia, mob tom qab brachial plexus raug mob, thiab lwm yam.
Thaum pregabalin siv rau hauv kev kho mob me me thiab mob hnyav, nws tuaj yeem ua ke nrog NSAIDs rau kev kho mob ntawm qhov mob me me, thiab nws tuaj yeem ua ke nrog opioids rau mob hnyav thiab mob hnyav. Rau qee cov neeg mob uas mob qog noj ntshav, mob pob txha, lossis mob tom qab hluav taws xob raug mob, pregabalin ua ke nrog opioids tuaj yeem siv los txo qhov mob. Tsis tas li ntawd, pregabalin tuaj yeem siv ua ke nrog cov tshuaj muaj zog opioids rau cov neeg mob uas mob hnyav. Cov kev mob tshwm sim ntawm pregabalin muaj xws li kev mob plab hnyuv thiab lub siab thiab lub raum puas, tab sis lawv yog me me.
Pregabalin muaj txiaj ntsig zoo hauv kev kho mob trigeminal neuralgia hauv ob peb hnub
Pregabalin feem ntau ua tau zoo hauv kev kho mob ntawm trigeminal neuralgia li ntawm kaum hnub. Trigeminal neuralgia yog ib hom kab mob hauv lub hlwb, uas yog tshwm sim los ntawm qhov mob rov tshwm sim nyob rau hauv trigeminal paj hlwb faib thaj tsam ntawm ib sab ntawm lub ntsej muag. Pregabalin capsule yog ib qho tshiab Y-aminobutyric acid receptor agonist, uas tuaj yeem thaiv cov kab hluav taws xob-nyob ntawm calcium thiab txo qhov tso tawm ntawm cov neurotransmitters. Nws yog tsuas yog siv rau kev kho mob ntawm peripheral neuralgia thiab adjuvant kho, uas tuaj yeem txo qee qhov qaug dab peg, xws li post-herpetic neuralgia thiab fibromyalgia syndrome.