Nebivolol hmoovyog lub cim thib peb ntawm lub sijhawm ntev thiab xaiv cov tshuaj 1 receptor blocker, nws cov yam ntxwv ntawm pharmacological zoo ib yam li lwm cov tswv cuab ntawm pawg receptor blocker sib txawv kiag li.
Tsuas yog los ntawm Ntxiv rau qhov siab ntawm lub plawv xaiv ntawm 1 receptor, nws tus yam ntxwv yog tias nws ua kom 3 receptors induces endothelial nitrogenase, uas ua rau nitric oxide nyob rau hauv vasodilation.
Cov txheej txheem ntawm vasodilation txawv ntawm lwm tus Receptor blockers, xws li rabelol lossis carvedilol, uas dhau los ntawm Receptor blockers ua tiav cov txiaj ntsig no.
Tsis tas li ntawd, NEBIVOLOL-D4 tsis muaj qhov ua rau muaj kev sib haum xeeb, yog li nws cov txiaj ntsig ua rau txo qis hauv myocardial oxygen noj thiab cov leeg nqaij zoo dua thiab chronotropic tsis zoo.
Dab tsi yog qhov zoo thiab qhov tsis zoo ntawm cov tshuaj antihypertensive?
Qhov kom zoo dua ntawm beta-blocker antihypertensive tshuaj yog tias lawv tuaj yeem txo cov ntshav siab thaum tseem muaj kev kho mob ntawm cov kab mob plawv, arrhythmia, myocardial hypertrophy, thiab lwm yam. myocardial contraction.
Nyob rau hauv xyoo tas los no, ntau thiab ntau tus neeg mob tau tshaj tawm tias kev kho mob ntshav siab thiab lub plawv dhia siab Lub peev xwm ntawm receptor blockers muaj kev cuam tshuam loj heev.
Cov tshuaj dab tsi hauv ntiaj teb no tuaj yeem txo qis lub plawv dhia thiab tswj ntshav siab, thaum tseem tiv thaiv kev sib deev tsis zoo?
Peb paub tias cov tshuaj tseem ceeb tam sim no cuam tshuam rau kev ua haujlwm ntawm kev sib deev yog Propanolol, uas tuaj yeem hais tias yog qhov hnyav tshaj plaws thiab muaj ntau. Betaloc metoprolol tuaj yeem ua rau penile sclerosis, ua rau muaj kev cuam tshuam ntawm erectile kawg. Cov yam ntxwv ntawm cov tshuaj ntawm atenolol yog qhov qis hauv lipid solubility, thiab nws qhov cuam tshuam rau kev ua haujlwm ntawm kev sib deev yog me me piv rau lwm cov tshuaj, tab sis nws tsis cuam tshuam tag nrho. Yog tias peb tus neeg mob noj cov tshuaj Lorraine hauv chav kawm saum toj no thiab lawv lub peev xwm sib deev tsis muaj zog tshwj xeeb, peb xav kom koj hloov khaub ncaws rau kev kho mob.
Tam sim no, tsuas yog Nebivolol yog thawj zaug ua tiav qhov kev ua tau zoo hauv cov ntsuas no. Nebivolol tsis tsuas yog muaj cov txiaj ntsig zoo tib yam li lwm cov tshuaj, tab sis kuj muaj cov txiaj ntsig ntawm peripheral me hlab ntsha dilation, uas tsis ua rau muaj kev pheej hmoo ntawm kev sib deev txiv neej.
Tsis tas li ntawd, nws kuj yog ib qho kev sib xyaw ntawm sab laug tes thiab sab xis isomers. Txoj cai-tes isomer muaj zog 1- receptor blockade nyhuv, thaum sab laug-tes isomer muaj cov nyhuv endothelial cell-dependent vasodilation. Kev xaiv ntau tshaj 1 receptor tuaj yeem cuam tshuam qhov kev siv ntawm 1 receptor los ntawm 290 npaug ntawm 2 receptor, thaum bisoprolol tsuas tuaj yeem ncav cuag 26 zaug, atenolol yog 15 zaug, thiab propranolol yog 119 zaug. Los ntawm qhov no, nws tuaj yeem pom tias antagonistic receptor 1 muaj peev xwm txhim kho vasodilation, nrog rau kev cuam tshuam tsawg kawg ntawm receptor 2, uas tsis ua rau muaj kev phiv ntawm lwm yam khoom zoo sib xws, xws li bronchial du nqaij contraction thiab vascular du nqaij contraction.
Hais txog kev hais lus, Nebivolol muaj kev zam zoo dua. Tsis tas li ntawd, nyob rau hauv qhov kev sim "ob qhov muag tsis pom kev", cov nyhuv antihypertensive ntawm Nebivolol muaj zog dua li ntawm Propanolol, zoo ib yam li amlodipine thiab tib yam li ntawm nifedipine, thiab txo qis diastolic ntshav siab dua li ntawm losartan.
Clinically, nws tseem tuaj yeem lees paub tias cov khoom no ua lub luag haujlwm hauv cov haujlwm no.