C08CA08 - nitrendipine ; belongs rau chav kawm ntawm dihydropyridine derivative xaiv calcium-channel blockers nrog cov teebmeem vascular. Siv rau hauv kev kho mob ntawm cov kab mob plawv.
Cov khoom txuas
https://www.faithful-chemical.com/api-powder/nitrendipine-powder-cas-39562-70-4.html
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Siv:
Peb paub tias tam sim no niaj hnub kev kho mob ntshav siab yog ua ke nrog guanethidine sulfate (cov tshuaj tiv thaiv ntshav siab) nrog dihydroquemide (cov tshuaj diuretic). Ntawm ib sab, dihydroquemide txo cov ntshav ntim thiab lub plawv tso zis los ntawm sodium diuresis, thiab ntawm qhov tod tes, nws tuaj yeem cuam tshuam ncaj qha rau vascular du nqaij, nthuav cov hlab ntsha, txo qis peripheral vascular tsis kam thiab ua rau txo qis ntshav siab. Yog li, ua ke nrog guanethidine sulfate tuaj yeem txhim kho cov nyhuv antihypertensive thiab txo qhov tshwm sim ntawm edema. Txawm li cas los xij, dihydrocresuloxide tso tawm ntau cov poov tshuaj, yooj yim ua rau hypokalemia, thiab yog tias kev sib xyaw ntawm nirendipine thiab dihydrocresuloxide tuaj yeem zam tsis tau hypokalemia. Vim tias cov khoom no tau tawm los ntawm sodium hauv cov zis, nws tsis tsuas yog pab cov neeg mob kom txo cov ntshav siab, tab sis kuj tseem muaj cov nyhuv inhibiting tso tawm aldosterone, yog li nws tsis ua rau hypokalemia.
Qhov thib ob tiam calcium antagonist yog ib qho tshuaj zoo tagnrho rau kev kho mob ntshav siab. Nws muaj qhov tseem ceeb thiab kav ntev antihypertensive thiab vasoconstrictive teebmeem. Nws yog haum rau ntau hom kev kub siab, xws li thawj thiab theem nrab mob ntshav siab me me thiab nruab nrab, thiab tseem tuaj yeem siv rau cov kab mob plawv, congestive plawv tsis ua hauj lwm thiab lwm yam.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
Lub plawv dhia li cas rau Nitrendipine?
Mob hnyav, nitrendipine (20 mg) ua rau thaum so kom txo qis hauv cov ntshav siab (los ntawm 194/100 txog 151/78 mm Hg) thiab nce hauv plawv dhia (los ntawm 81 txog 101 neeg ntaus / min); Lub plawv tso zis tsis hloov pauv thiab cov kab mob vascular tsis kam poob los ntawm 30%.
Dab tsi yog bioavailability ntawm nitrendipine?
Kev tshem tawm ntawm lub cev tsis hloov pauv tab sis lub davhlau ya nyob twg tshem tawm ib nrab-lub neej yog me ntsis ntev mus rau 10.5 h. Qhov no nce nyob rau hauv ib nrab-lub neej yog vim muaj kev nce ntim ntawm kev faib tawm. Bioavailability, uas yog 21.2%, tsis hloov pauv tag nrho hauv lub raum tsis ua haujlwm.
Dab tsi yog ib nrab lub neej ntawm nitrendipine?
Nyob rau hauv cov nqe lus ntawm cov tshuaj ib nrab-lub neej, nitrendipine muaj ib nrab-lub neej ntawm 12-24 teev.
Hauv kev kub siab, kev khi ntawm nitrendipine ua rau txo qis qhov tshwm sim ntawm L-hom calcium channels thiab txo cov calcium nkag. Qhov txo qis ntawm calcium tiv thaiv cov leeg nqaij leeg hauv cov leeg nqaij. Kev tiv thaiv ntawm cov leeg nqaij contraction ua rau cov leeg nqaij du. Dilation ntawm vasculature txo tag nrho cov peripheral tsis kam, uas txo cov haujlwm ntawm lub plawv thiab tiv thaiv kev caws pliav ntawm lub plawv lossis lub plawv tsis ua haujlwm.
Nitrendipine kuj tau pom los ua tus antagonist ntawm cov mineralocorticoid receptor, los yog raws li ib tug antimineralocorticoid.
Cov cuab yeej tshuaj
Yellow crystalline los yog crystalline hmoov, tsw thiab tasteless. Susceptible rau deterioration nyob rau hauv lub teeb. Soluble hauv acetone lossis chloroform, me ntsis soluble hauv methanol lossis ethanol, me ntsis soluble hauv dej. Melting point 156 ~ 159 degree.
Cov lus nug nquag
Koj puas muaj teeb meem xa tuaj rau kuv lub tebchaws?
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A: Peb muaj warehouses nyob teb chaws Europe, America thiab Australia. Nyob rau tib lub sijhawm, yog tias koj tuaj ntawm Tebchaws Europe, cov khoom tuaj yeem raug xa los ntawm lub teb chaws Yelemees, thiab yog tias koj tuaj ntawm Asmeskas lossis Canada, cov khoom tuaj yeem xa los ntawm California.
Cov khoom ntim li cas?
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A: Peb feem ntau xa cov khoom nrog cov khoom pov tseg sab nraud thiab ob txheej txheej sterile pob tshab hauv lub hnab.Peb tau sim ntau txhiab txoj hauv kev, nws zoo li hnyav thiab tsis pom kev.
Thaum twg koj yuav xa tawm cov khoom tom qab them nyiaj tiav?
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A: Feem ntau qhov kev txiav txim yuav xa tuaj tsis pub dhau 3-7 hnub tom qab qhov kev txiav txim tau lees paub, tshwj tsis yog cov khoom lag luam customized.
Yuav ua li cas mus txiav txim?
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A: Thov cia kuv paub cov khoom koj tab tom nrhiav, kom muaj nuj nqis thiab lub teb chaws qhov chaw uas pab kuv muab tus nqi tsim nyog; Tom qab koj lees paub tag nrho cov ntsiab lus ntawm kev txiav txim, them nyiaj ua ntej thiab muab qhov chaw nyob Shipping rau peb.Peb npaj cov khoom xa tuaj. thawj zaug tom qab tau txais kev them nyiaj thiab muab kev pab cuam tom qab muag tom qab koj tau txais parcel.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com