Xi'an Faithful BioTech Co., Ltd. yog muag Melanotan II Raw Powder. Thov koj xav tiv tauj peb yog tias koj muaj kev xav tau kev yuav khoom.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
I. Product Core Overview: Los ntawm Chemical Essence mus rau Basic Properties
Melanotan II Powder yog qhov tseem ceeb ntawm cov txheej txheem ua kom zoo dua cyclic heptapeptide compound uas ua tiav kev ua kom muaj txiaj ntsig ntawm melanocortin receptors (MCRs) los ntawm kev ua raws li kev ua haujlwm lom neeg ntawm tib neeg lub cev ntuj tsim -MSH. Nws cov ntaub ntawv tseem ceeb tshuaj thiab cov khoom siv lub cev yog qhov tsim nyog ua ntej rau kev tshawb fawb. Hauv qab no yog cov txheej txheem txheej txheem ntawm cov txheej txheem tseem ceeb.
1.1 Cov yam ntxwv ntawm cov tshuaj lom neeg
Cov khoom no muaj cov cim qhia tseeb thiab cov qauv molecular. CAS Registry Number 121062-08-6 yog ib qho kev lees paub thoob ntiaj teb kev txheeb xyuas cov khoom siv, tso cai kom rov qab tau cov ntaub ntawv muaj feem cuam tshuam los ntawm cov ntaub ntawv tshuaj engineering. Los ntawm qhov kev xav ntawm molecular muaj pes tsawg leeg, nws cov mis molecular yog C50H69N15O9, nrog cov txheeb ze molecular loj ntawm kwv yees li 1024.18 g / mol. C47H68N14O10 cov mis mos molecular pom nyob rau hauv qee qhov kev tshawb fawb vim qhov sib txawv ntawm qhov sib txawv yog vim qhov sib txawv me me ntawm cov amino acid residue suav txoj kev; cov qauv tseem ceeb nyob ib puag ncig.
Nws cov polypeptide sequence yog Ac-Nle-Asp-His-D-Ph-Arg-Trp-Lys-NH₂. Cov yam ntxwv tseem ceeb tshaj plaws yog lub intramolecular cyclization ntawm 4- txoj hauj lwm leucine (Nle⁴) thiab 10- txoj hauj lwm lysine (Lys¹⁰). Qhov kev hloov kho no ua rau nws muaj zog receptor binding affinity thiab tiv thaiv protease degradation dua ntuj -MSH, txhim kho nws biostability. Tsis tas li ntawd, N-terminal acetylation (Ac-) thiab C-terminal amidation (-NH₂) ua kom zoo dua nws cov khoom siv hluav taws xob thiab hauv vivo metabolic yam ntxwv.
1.2 Cov Khoom Siv Lub Cev thiab Cov Lus Qhia Cia
Raws li kev tshawb fawb -qib raw khoom, Melanotan II Powder feem ntau yog dawb los tawm -cov hmoov dawb lyophilized uas tsis muaj ntxhiab tsw. Nws muaj cov dej solubility ntau dua 20 mg / ml ntawm 25 degree, solubility zoo dua hauv dimethyl sulfoxide (DMSO), thiab solubility me ntsis hauv nruab nrab tsis. Nws cov physicochemical tsis pom muaj qhov ntom ntawm 1.43, qhov ntsuas qhov ntsuas ntawm 1.669, qhov taw tes isoelectric ntawm kwv yees li 7.8-8.3, thiab tsis muaj zog alkalinity. Cov yam ntxwv no muab lub hauv paus rau kev xaiv cov kuab tshuaj thiab kev npaj concentration hauv kev sim.
Cov xwm txheej khaws cia yog qhov tseem ceeb los ua kom nws cov kev ua haujlwm lom neeg. Raws li cov kev qhia tshwj xeeb ntawm ntau tus neeg xa khoom, ntev - lub sijhawm cia yuav tsum muaj qhov ziab, lub teeb - tiv thaiv ib puag ncig ntawm -20℃, nrog lub txee lub neej txog li 2 xyoos; nyob rau hauv ultra- qhov kub thiab txias ntawm -80 degree, lub txee lub neej tuaj yeem txuas ntxiv mus rau ntau tshaj 2 xyoos; Nyob rau hauv chav tsev kub, nws yuav tsum tau muab kaw thiab tiv thaiv los ntawm ya raws, thiab lub sij hawm cia yuav tsum tsis txhob ntau tshaj 72 teev. Rov ua dua lub voj voog khov-thaw yuav ua rau peptide saw degradation, cuam tshuam rau kev sim. Thaum lub sij hawm kev thauj mus los, cov hnab ntim dej khov lossis cov dej khov qhuav qhuav yuav tsum tau siv los xyuas kom meej tias qhov kub thiab txias nyob hauv qab 2-8 degree.
II. Core Mechanism of Action: Ntau -Timget Regulatory Biological Effects
Kev ua haujlwm lom neeg ntawm Melanotan II Powder yog los ntawm nws qhov dav -spectrum agonistic kev ua haujlwm tawm tsam melanocortin receptor tsev neeg (MCRs). MCRs, raws li G protein-coupled receptors, suav nrog tsib subtypes los ntawm MC1R mus rau MC5R, dav dav hauv daim tawv nqaij, hauv nruab nrab paj hlwb, thiab cov ntaub so ntswg adipose. MT-II ua kom cov kev taw qhia tshwj xeeb los ntawm kev khi rau cov subtypes sib txawv, ua tiav ntau- qhov kev cai ntawm lub cev.
2.1 Molecular Pathway ntawm daim tawv nqaij Pigmentation Regulation
Hauv cov txheej txheem ntawm melanin ntau lawm hauv daim tawv nqaij, lub hom phiaj tseem ceeb ntawm MT-II yog MC1R nyob rau saum npoo ntawm melanocytes. Thaum MT-II khi rau MC1R, nws thawj zaug activates intracellular G s protein, txhawb kev ua kom adenylate cyclase (AC), uas converts adenosine triphosphate (ATP) mus rau cyclic adenosine monophosphate (cAMP). Kev nce qib cAMP txuas ntxiv qhib cov protein kinase A (PKA). PKA, los ntawm phosphorylation, activates microphthalmia-associated transcription factor (MITF), ib tug tseem ceeb regulator ntawm melanin synthesis, uas ua rau kom cov noob qhia ntawm cov enzymes tseem ceeb xws li tyrosinase thiab tyrosinase-ssociated protein 1 (TRP-1).
Tyrosinase, raws li tus nqi - txwv enzyme nyob rau hauv melanin synthesis, accelerates kev hloov ntawm tyrosine mus rau dopaquinone los ntawm kev ua kom muaj zog, ua rau zus tau tej cov eumelanin thiab pheomelanin los ntawm ib tug series ntawm biochemical tshuaj. Ib txhij, MT-II txhawb kev loj hlob thiab kev thauj mus los ntawm melanosomes los ntawm kev txhim kho cov kev qhia ntawm cov proteins xws li PMEL17 thiab MART-1, ua kom cov melanin granules los ntawm melanocytes mus rau keratinocytes, thaum kawg txhim kho cov tawv nqaij pigmentation. Qhov no sab hauv-tawm pigmentation mechanism tso cai rau cov tawv nqaij los tsim ib tug darker complexion txawm nrog txo UV raug, yog li pab txhawb nws tiv thaiv ultraviolet hluav taws xob.
2.2 Ntau yam teebmeem ntawm Metabolic thiab Neural Regulation
Nyob rau hauv lub hauv paus paj hlwb, MT-II feem ntau exerts nws metabolic tswj los ntawm kev khi rau MC4R. Nws tuaj yeem hla cov ntshav- hlwb teeb meem thiab khi rau MC4R hauv lub arcuate nucleus ntawm hypothalamus, ua kom cov G q/11 protein-mediated phospholipase C (PLC) taw qhia txoj hauv kev, tsim cov inositol triphosphate (IP₃) thiab cov calcium ntau ntxiv (daccelionglycerol). Qhov kev hloov pauv no cuam tshuam qhov kev qhia ntawm kev qab los noj mov- txhawb nqa yam xws li neuropeptide Y (NPY) thaum txhim kho kev ua haujlwm ntawm -MSH, ua cov khoom lag luam ntawm pro-opioid glycosides (POMC), ua tiav ob qho txiaj ntsig ntawm kev qab los noj mov thiab nce kev siv zog.
Hais txog kev tswj hwm kev noj qab haus huv ntawm kev sib deev, MT-II qhib MC4R hauv ob qho tib si hauv nruab nrab thiab sab hauv lub paj hlwb, txhawb kev qhia txog nitric oxide (NO) synthase thiab nce NO tso tawm. TSIS txhim kho cov ntshav hauv zos los ntawm dilating cov hlab ntsha, tshwj xeeb tshaj yog cov hauv nruab nrog cev, yog li txhawb erection. Cov txheej txheem no ua rau nws yog ib qho cuab yeej tseem ceeb rau kev tshawb fawb txog erectile kawg. Tsis tas li ntawd, tom qab MT-II khi rau MC3R, nws tuaj yeem cuam tshuam cov teeb meem nuclear-κB (NF-κB) txoj kev taw qhia, txo qhov kev tso tawm ntawm pro-cov teeb meem mob xws li TNF- thiab IL-6, thiab txhawb kev qhia tawm ntawm lub hlwb ({13}) thiab cov tshuaj tiv thaiv neurotrophic. neuroprotective muaj peev xwm.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
III. Daim ntawv thov tseem ceeb: Tus nqi tseem ceeb hauv kev tshawb fawb thiab kev loj hlob
Raws li qib siab -kev tshawb fawb purity- qib peptide raw khoom, Melanotan II Powder feem ntau yog siv rau hauv kev tshawb fawb kho mob, kev tsim tshuaj, thiab kev tshawb nrhiav lub cev. Nws ntau - lub hom phiaj kev ua haujlwm muab cov cuab yeej tshawb fawb tseem ceeb rau ntau yam kev qhuab qhia.
3.1 Cov cuab yeej tseem ceeb rau kev tshawb fawb kab mob ntawm daim tawv nqaij
Hauv thaj chaw ntawm pigmentary ntshawv siab, MT-II yog cov khoom tseem ceeb rau kev kawm cov txheej txheem ntawm cov kab mob xws li vitiligo thiab albinism. Los ntawm kev ntxiv exogenously nrog MT-II, cov kws tshawb fawb tuaj yeem soj ntsuam nws cov kev tswj hwm ntawm melanocyte proliferation thiab melanin synthesis hauv thaj tsam ntawm daim tawv nqaij, thiab ntsuam xyuas cov peev xwm kho mob ntawm kev ua kom cov kab mob endogenous melanin ntau lawm. Cov kev tshawb fawb preclinical tau pom tias cov tshuaj pleev ib ce ntawm MT-II kev npaj tuaj yeem ua tiav 40%-60% pigment rov qab tus nqi hauv thaj tsam ntawm daim tawv nqaij ntawm vitiligo qauv tsiaj, muab cov pov thawj sim rau kev txhim kho cov tshuaj kho cov xim xim.
Hauv kev tshawb fawb txog kev tiv thaiv daim tawv nqaij, MT-II yog siv los tshawb nrhiav cov txheej txheem tiv thaiv kev puas tsuaj rau ultraviolet. Vim hais tias nws induced melanin ntau lawm txhim kho daim tawv nqaij tus kheej lub hnub tiv thaiv muaj peev xwm, cov kws tshawb fawb tau siv MT-II kev cuam tshuam los soj ntsuam cov nyhuv ntawm melanin tiv thaiv UVB-induced DNA puas thiab oxidative kev nyuaj siab, muab theoretical kev txhawb rau kev loj hlob ntawm tshiab photoprotective agents. Tsis tas li ntawd, nws muaj kev siv dav hauv kev tshawb fawb pathogenesis ntawm cov kab mob xws li melasma thiab post-inflammatory hyperpigmentation.
3.2 Kev Tshawb Fawb Cov Lus Qhia hauv Cov Kab Mob Metabolic thiab Neurological
Raws li tus muaj zog MC4R agonist, MT-II muab cov cuab yeej tseem ceeb rau kev tshawb fawb txog cov kab mob metabolic xws li rog rog thiab ntshav qab zib hom 2. Cov kws tshawb fawb siv nws txoj kev qab los noj mov-txhaj tshuaj thiab lub zog metabolism- tswj cov teebmeem los ua lub hom phiaj siv tau thiab qhia txog txoj hauv kev tsom xam, tso lub hauv paus rau kev txhim kho MC4R agonist agonist los tiv thaiv - rog rog. Cov kev tshawb fawb ntsig txog tau lees paub tias MT-II tuaj yeem nce qib ntawm cov tsis yog -esterified fatty acids (NEFA) hauv cov tsiaj sim thiab txhawb lipid mobilization, muab qhov kev xav tshiab rau kev tshawb fawb lipid metabolism.
Hauv kev tiv thaiv neuroprotection, cov tshuaj tiv thaiv -inflammatory thiab antioxidant zog ntawm MT-II ua rau nws yog ib qho kev tshawb fawb txog cov kab mob neurodegenerative xws li ischemic stroke thiab Parkinson's disease. Cov kev sim tsiaj tau pom tias MT-II tuaj yeem txo qhov ntim ntawm infarct thiab txhim kho lub cev muaj zog hauv nas nrog mob stroke; nyob rau hauv tus qauv Parkinson tus kab mob, nws tuaj yeem tiv thaiv dopaminergic neurons thiab txo cov tsos mob tremor. Cov kev tshawb pom no muab cov lus qhia tshiab rau kev tsim cov tshuaj rau kev kho cov kab mob neurological.
IV. Cov qauv kev nyab xeeb: Ib qho tseem ceeb ua ntej rau kev siv Scientific
Raws li kev tshawb fawb-qib cov ntsiab lus, kev siv nyab xeeb ntawm Melanotan II Powder tso siab rau cov txheej txheem kev khiav hauj lwm nruj thiab kev tswj xyuas kom meej. Tam sim no, nws "rau kev tshawb fawb siv nkaus xwb, tsis yog rau tib neeg siv" tus cwj pwm tau qhia meej meej thoob ntiaj teb, thiab txhua daim ntawv thov tib neeg tsis pom zoo muaj peev xwm txaus ntshai.
4.1 Kev ceev faj txog kev nyab xeeb rau kev sim ua haujlwm
Hauv cov ntawv thov kev sim, kev tuav ntawm MT-II hmoov yuav tsum ua raws li cov lus qhia dav dav rau peptide reagents. Sterile physiological saline los yog buffer tov yuav tsum tau siv rau dissolution; zam kev sib cais ncaj qha nrog cov kais dej vim qhov no yuav txo qis kev ua haujlwm. Tom qab kev npaj, cov tshuaj yuav tsum tau khaws cia ntawm 2-8℃rau ib lub sij hawm luv luv thiab siv li ntawm 48 teev. Cov neeg ua haujlwm hauv chaw kuaj mob yuav tsum hnav hnab looj tes, tsom iav, thiab lwm yam khoom siv tiv thaiv kom tsis txhob nqus cov hmoov los yog tawv nqaij ncaj qha. Yog tias muaj kev sib cuag, tam sim ntawd yaug nrog dej ntau.
V. Txoj Kev Loj Hlob
Hais txog kev tshawb fawb thiab kev loj hlob tiam sis, cov kev taw qhia tseem ceeb tam sim no yog los txhim kho receptor selectivity thiab optimize pharmacokinetic zog. Vim tias MT-II ntau- lub hom phiaj kev ua si ua rau muaj kev phiv ntau heev, cov kws tshawb fawb tau siv computer- pab tsim cov khoom siv thev naus laus zis los hloov kho peptide saw qauv ntawm MT-II raws li cov qauv siv lead ua ntawm MC4R thiab MC1R, txhawm rau tsim cov agonists uas muaj kev xaiv zoo heev.
Xaus
Melanotan II hmoov, peptide reagent nrog cov khoom siv lom neeg tshwj xeeb, ua lub luag haujlwm hloov tsis tau hauv kev tshawb fawb hauv dermatology, kab mob metabolic, thiab neuroprotection. Nws nyob rau hauv - kev tswj qhov tob ntawm melanocortin receptor system muab cov cuab yeej tseem ceeb rau kev nkag siab txog cov txheej txheem physiological thiab tsim cov khoom tshiab. Txawm li cas los xij, nws qhov kev pheej hmoo ntawm kev nyab xeeb thiab cov kev cai nruj tswj hwm hais tias nws yuav tsum tau siv nyob rau hauv kev tswj hwm kev tshawb fawb.
Rau cov kws tshawb fawb, xaiv qhov siab -purity, cov khoom raug cai yog qhov yuav tsum tau ua ua ntej kom ntseeg tau tias kev tshawb fawb zoo; nruj me ntsis ua raws li cov txheej txheem kev khiav hauj lwm thiab cov kev cai tswj hwm yog qhov tseem ceeb ntawm kev txo cov kev pheej hmoo ntawm kev nyab xeeb. Yav tom ntej, nrog rau kev txhim kho peptide synthesis thev naus laus zis thiab cov tswv yim tsim, MT-II derivatives yuav hloov zuj zus mus rau kev xaiv ntau dua thiab siv sijhawm ntev dua ntawm kev nqis tes ua, ntxiv kev qhib lawv cov txiaj ntsig hauv kev tshawb fawb tshuaj thiab kev tsim kho thiab coj kev cia siab tshiab rau kev kho mob ntau dua.
Raws li tus neeg muab kev pabcuam zoo tshaj Melanotan II CAS 121062-08-6, Xi'an Faithful BioTech Co., Ltd. leverages xeev- ntawm- the-art production technology and rigorous quality assurance to as international pharmaceutical requirements. Peb txoj kev mob siab rau kev ua tau zoo tshaj plaws, tus nqi tsim nyog, thiab kev txhawb nqa kev tsim kho tau ua rau peb nyiam koom tes rau cov kws kho mob thiab cov kws tshawb fawb thoob ntiaj teb. Txhawm rau kom tau txais cov ncauj lus qhia ntxaws ntxaws thiab daim ntawv thov kev taw qhia rau peb Melanotan II Powder, hu rau peb pab neeg ua haujlwm ntawmsales4@faithfulbio.comthiab tshawb xyuas seb peb cov khoom tuaj yeem txhim kho koj cov khoom tsim li cas.