Xi'an Faithful BioTech Co., Ltd. yog muag SLU-PP-332 Raw Powder. Thov koj xav tiv tauj peb yog tias koj muaj kev xav tau kev yuav khoom.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
I. Cov ntaub ntawv khoom siv yooj yim
SLU-PP-332 muaj cov cim qhia tshuaj lom neeg thiab cov khoom siv physicochemical, cov yam ntxwv tseem ceeb tseem ceeb rau nws daim ntawv thov hauv kev tshawb fawb kev sim. Nws cov ntaub ntawv tseem ceeb tshuaj muaj raws li hauv qab no: CAS naj npawb 303760-60-3, molecular mis C₁₈H₁₄N₂O₂, molecular hnyav 290.32. Lub cev, cov khoom no yog cov hmoov dawb rau cov hmoov dawb, ua kom yooj yim rau kev hnyav thiab kev sib cais hauv kev sim.
Hais txog physicochemical zog, SLU-PP-332 muaj qhov kwv yees qhov ceev ntawm 1.20 ± 0.1 g / cm³ thiab acidity coefficient (pKa) ntawm 8.44 ± 0.15. Cov kev txwv no muab cov ntaub ntawv siv rau kev ua kom zoo dua nws qhov kev sib cais thiab cov tshuaj tiv thaiv hauv cov tshuab sib txawv. Solubility yog tus yam ntxwv tseem ceeb ntawm kev tshawb fawb reagents. Qhov sib xyaw no nthuav tawm zoo solubility hauv dimethyl sulfoxide (DMSO), ncav cuag 2 mg / mL nyob rau hauv qhov chaw sov kom tsim tau cov kua ntshiab. Cov yam ntxwv no tso cai rau nws ua tiav hauv kev sim ntawm tes thiab hauv vitro biochemical cov tshuaj tiv thaiv kab mob. Hais txog kev cia khoom, kom ntseeg tau tias nws cov dej num thiab kev ruaj ntseg, nws yuav tsum tau muab cia rau hauv qhov chaw kaw ntawm qhov kub ntawm 2-8℃kom tsis txhob muaj kev puas tsuaj rau nws cov qauv los ntawm lub teeb, kub, thiab av noo, uas yuav cuam tshuam rau kev sim.
II. Core Mechanism of Action
Lub luag haujlwm tseem ceeb ntawm kev ua ntawm SLU-PP-332 nyob rau hauv nws lub luag haujlwm ua lub lauj kaub -estrogen receptor-associated receptor (ERR) agonist. Nws tshwj xeeb khi rau thiab ua kom muaj peb hom subtypes ntawm ERR tsev neeg: ERR , ERR , thiab ERR , nthuav tawm cov kev sib txawv sib txawv rau ntau hom subtypes. Qhov siab tshaj plaws affinity yog rau ERR, nrog EC₅₀ tus nqi tsuas yog 98 nM, thaum EC₅₀ tus nqi rau ERR thiab ERR yog 230 nM thiab 430 nM, raws li. ERR tsev neeg receptors yog cov tswv cuab tseem ceeb ntawm cov neeg txais kev noj qab haus huv hauv lub ntiaj teb, muaj kev koom tes hauv cov txheej txheem physiological tseem ceeb xws li lub zog metabolism, kev tswj hwm kev ua haujlwm mitochondrial, thiab kev loj hlob ntawm cov leeg. Lawv lub xeev kev ua haujlwm ncaj qha cuam tshuam rau qhov kev qhia ntawm cov noob caj noob ces hauv qab.
Tshwj xeeb, tom qab SLU-PP-332 khi rau ERR receptor, nws sib koom ua ke nrog cov coactivators xws li peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1) txhawm rau txhim kho cov kev qhia ntawm cov noob ntsig txog mitochondrizing oxidation genesis thiab oxidation genesis. mitochondrial muaj nuj nqi thiab cellular ua pa efficiency. Raws li lub xov tooj ntawm tes "lub zog fais fab," txhim kho mitochondrial muaj nuj nqi tseem ceeb txhim kho cellular zog metabolism thiab txhawb kev tsim ntawm hom IIa oxidative skeletal nqaij fibers. Cov fibers no muaj peev xwm oxidative metabolic siab, pab txhawb kev ua siab ntev thiab ua haujlwm ntev. Tsis tas li ntawd, txoj hauv kev no tuaj yeem tswj hwm cov kev qhia ntawm cov noob ntsig txog fatty acid oxidation thiab qabzib metabolism, ua tiav kev tswj hwm ntawm metabolic homeostasis, uas yog lub laj thawj tseem ceeb rau nws cov txiaj ntsig tseem ceeb hauv kev tshawb fawb kab mob metabolic.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
III. Cov ntaub ntawv tseem ceeb Bioactivity
Lub bioactivity ntawm SLU-PP-332 tau ua tiav tag nrho los ntawm ntau qhov kev sim hauv vitro cell, muab cov ntaub ntawv txhawb nqa rau nws cov ntawv thov tshawb fawb.
Hauv kev sim hauv vitro, siv C2C12 cov leeg nqaij ua cov qauv kev tshawb fawb, kev kho cov hlwb nrog SLU-PP-332 ntawm qhov ntau ntawm 0-5 μM rau 24 teev ua rau muaj kev cuam tshuam loj heev rau kev qhia qib ntawm ERR hom phiaj, nrog rau kev nthuav qhia ntawm pyruvate dehydrogenase kinase 4 (PDK4). Nyob rau tib lub sijhawm, nws ua rau mitochondrial biogenesis hauv proliferating C2C12 hlwb, ua kom muaj zog ua pa ntawm mitochondrial. Qhov txiaj ntsig no qhia ncaj qha rau nws cov haujlwm hauv kev tswj hwm lub zog metabolism thiab kev ua haujlwm mitochondrial hauv cov leeg nqaij, muab cov pov thawj hauv vitro simulation rau nws "lub cev muaj zog simulation" cov yam ntxwv ua haujlwm.
IV. Main Application Prospects
Raws li nws cov txheej txheem meej ntawm kev ua haujlwm thiab kev ua haujlwm zoo heev, SLU-PP-332 qhia dav dav daim ntawv thov kev cia siab nyob rau hauv ntau yam kev tshawb fawb, tshwj xeeb tshaj yog nyob rau hauv kev tshawb fawb kab mob metabolic, kev tswj cov leeg nqaij, thiab kev tshawb nrhiav cov txheej txheem kev laus, qhov uas nws muaj txiaj ntsig tsis hloov.
Hauv kev tshawb nrhiav cov kab mob metabolic, SLU-PP-}332 tuaj yeem ua cov cuab yeej tshawb fawb tseem ceeb rau kev tshawb nrhiav cov txheej txheem pathological ntawm cov kab mob metabolic xws li rog rog, ntshav qab zib hom 2, thiab tsis yog - haus dej cawv fatty siab kab mob. Nws cov khoom ntawm kev txhim kho insulin rhiab heev, txhawb lipid oxidation, thiab tswj cov piam thaj metabolism muab cov phiaj xwm tseem ceeb thiab cov lus qhia txog kev tsim cov khoom kho tshiab rau cov kab mob no. Piv txwv li, hauv kev tshawb fawb txog kev noj zaub mov vim kev rog rog, qhov sib xyaw no tuaj yeem siv los txheeb xyuas qhov cuam tshuam ntawm ERR agonists ntawm cov kab mob metabolic, muab cov ntaub ntawv kho mob rau kev tsim khoom.
Hauv kev tswj hwm cov leeg nqaij, vim tias nws tuaj yeem ua raws li cov cim qhia ua haujlwm aerobic, txhim kho mitochondrial muaj nuj nqi, nce qhov feem ntawm oxidized skeletal nqaij fibers, thiab txhim kho kev ua haujlwm siab, nws tuaj yeem siv rau hauv kev tawm dag zog lub cev tshawb fawb los tshawb txog cov txheej txheem molecular ntawm kev txhim kho cov leeg nqaij. Nyob rau tib lub sijhawm, rau cov leeg ua haujlwm poob qis los ntawm kab mob, kev laus, lossis kev muaj peev xwm ua haujlwm tsawg, SLU-PP-332 muab cov cuab yeej tseem ceeb rau kev tshawb fawb txog cov tswv yim cuam tshuam, thiab xav kom muaj kev nkag siab tshiab rau cov kab mob xws li cov leeg nqaij atrophy thiab sarcopenia.
Hauv kev laus -kev tshawb fawb txog kev laus, nws cov khoom ntawm kev thim rov qab mitochondrial tsis ua haujlwm thiab txo qis qis ua rau nws muaj feem xyuam rau kev tshawb nrhiav cov txheej txheem kev laus, tshwj xeeb tshaj yog nyob rau hauv kev tshawb fawb txog kev laus ntawm lub cev (xws li kev laus rau lub raum) thiab hnub nyoog- cuam tshuam txog metabolic poob. Tsis tas li ntawd, kev tshawb fawb tau pom tias nws tuaj yeem koom nrog hauv kev tswj hwm circadian atherosclerosis thiab kev tiv thaiv neuroinflammation, muab cov kev taw qhia muaj peev xwm rau kev tshawb fawb txog cov kab mob neurodegenerative.
Xaus
SLU-PP-332, lub lauj kaub tshwj xeeb heev-ERR agonist, tau dhau los ua cov cuab yeej tshawb fawb tseem ceeb hauv thaj chaw xws li cov kab mob metabolic, kev tswj hwm cov leeg nqaij, thiab cov txheej txheem kev laus vim nws qhov dej zoo-txhais tau tias kev ua haujlwm, kev ua haujlwm lom neeg zoo heev, thiab kev siv dav dav. Nws cov purity siab, muaj ntau yam specifications, thiab ruaj khov muab kev txhawb nqa kev sim siab rau cov kws tshawb fawb thoob ntiaj teb. Raws li kev tshawb fawb txuas ntxiv mus ntxiv, tus nqi ntawm SLU-PP-332 hauv kev tshawb nrhiav cov khoom tshiab lub hom phiaj thiab tshawb nrhiav cov tswv yim tiv thaiv kab mob yuav dhau los ua qhov tseem ceeb, ua rau muaj kev cuam tshuam tshiab rau kev tshawb fawb thiab kho cov kab mob cuam tshuam.
Raws li tus neeg muab kev pabcuam zoo tshaj plaws SLU-PP-332 CAS 303760-60-3, Xi'an Faithful BioTech Co., Ltd. leverages xeev- ntawm- the-art production technology and rigorous quality assurance to the international pharmaceutical requirements. Peb txoj kev mob siab rau kev ua tau zoo tshaj plaws, tus nqi tsim nyog, thiab kev txhawb nqa kev tsim kho tau ua rau peb nyiam koom tes rau cov kws kho mob thiab cov kws tshawb fawb thoob ntiaj teb. Txhawm rau kom tau txais cov ncauj lus qhia ntxaws ntxaws thiab daim ntawv thov kev taw qhia rau peb SLU-PP-332 Powder, hu rau peb pab neeg ua haujlwm ntawmsales4@faithfulbio.comthiab tshawb xyuas seb peb cov khoom tuaj yeem txhim kho koj cov khoom tsim li cas.