Lamotrigine hmoov, ib qho qhia txog kev qaug dab peg: cov menyuam yaus thiab cov neeg laus hnub nyoog tshaj 12 xyoos: 1. Ib feem ntu yooj yim 2. Cov ntu ntu ntu ntu 3. txuas ntxiv lub cev muaj zog-clonic Kev sib deev 4. Lub hauv paus system muaj zog-kuaj kho mob. Tam sim no tsis pom zoo rau cov menyuam yaus hnub nyoog qis dua 12 xyoos. Kev kho ntxiv rau cov menyuam yaus thiab cov neeg laus thaum muaj hnub nyoog ob xyoos: 1. Tej ntu ntu ntu 2. Cov ntu ntu ntu ntu 3. Kev ua haujlwm txuas ntxiv - Clonic tawm tsam 4. Thawj lub cev muaj zog-clonic Kev sib deev qaug dab peg Cov khoom no kuj siv tau los kho mob qaug dab peg nrog Lennox-Gastaut syndrome.
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| Lamotrigine hmoov | Lamotrigine Molecular formula |
Khoom siv
Lamotrigine hmoovyog sodium ion siab channel blocker nrog kaw voltage thov ua raws. Nyob rau hauv kab lis kev cai paj hlwb, nws tsim ib tug tas mus li kev tso tawm ntawm daim ntawv thov thiab voltage ua raws li thaiv, inhibits kev tso tawm ntawm pathological glutamate (qhov no amino acid plays lub luag hauj lwm tseem ceeb nyob rau hauv tsim ntawm qaug dab peg), thiab kuj inhibits qhov tawg ntawm glutamate-induced kev txiav txim. peev xwm.
Lamotrigine hmoovyog haum rau poj niam qaug dab peg, hluas nkauj qaug dab peg, thiab senile epilepsy. Rau cov neeg muaj hnub nyoog tshaj 12 xyoos, tsis pom zoo siv rau cov hnub nyoog qis dua 12 xyoos, xws li kev qaug dab peg ib nrab, kev qaug dab peg ib nrab, ob qho tib si tonic-clonic qaug dab peg, thawj feem ntau tonic-clonic qaug dab peg, thiab lwm yam.
Pab cov neeg mob qaug dab peg ntau dua ob xyoos, uas yog, nws tuaj yeem siv thaum ntxiv kev kho mob, tab sis nws yog qhov nyuaj heev rau kev siv, yog li peb yuav tsum xam raws li tus neeg mob tus mob, qhov hnyav, thiab lwm yam, thiab tshaj tawm cov phiaj xwm kho kom raug. Cov txheej txheem ntxiv yuav tsum tau ua raws li kev taw qhia ntawm cov kws kho mob, uas yog qhov nyuaj heev, kev tshaj lij, thiab kev kawm. Yog li ntawd, cov neeg mob yuav tsum siv cov tshuaj no raws li kev qhia ntawm kws kho mob kom tsis txhob muaj kev phiv thiab kev tsim txom, thiaj li ua tiav cov txiaj ntsig zoo.
Khoom Specification
Yam khoom | Specification | Cov txiaj ntsig |
Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Dawb hmoov |
Solubility | Sparingly soluble hauv dej, me ntsis soluble hauv Methanol, Xyaum insoluble hauv heptane | Ua raws |
Kev txheeb xyuas | IR | Ua raws |
HPLC: Lub hauv paus ncov hauv chromatogram tau txais nrog cov tshuaj ntsuam xyuas zoo sib xws hauv lub sijhawm khaws cia thiab qhov loj me rau lub ntsiab lus tseem ceeb hauv chromatogram tau txais nrog kev siv tshuaj (a) rau impurity A, B, thiab C. | Ua raws | |
Kev tsis haum A, B, C, D | Lactam Impurity Tsawg dua lossis sib npaug rau 0.15% | 0.03% |
B-Pregabalin Tsawg dua lossis sib npaug rau 0.15% | 0.04% | |
Mandelic Acid Tsawg dua lossis sib npaug rau 0.1% | N.D | |
Lactam Ester Tsawg dua lossis sib npaug rau 0.1% | N.D | |
Yam khoom muaj feem | Unspecified nonpolar impurity Tsawg dua los yog sib npaug rau 0.1% | 0.036% |
Unspecified Polar impurity Tsawg dua los yog sib npaug rau 0.1% | 0.050% | |
Tag nrho impurities Tsawg dua lossis sib npaug rau 0.5% | 0.118% | |
Poob rau ziab | Tsawg dua los yog sib npaug rau 0.5% | 0.23% |
Sulfated tshauv | Tsawg dua lossis sib npaug rau 0.1% | 0.03% |
Kev ntsuam xyuas los ntawm HPLC | 98.0%~102.0% w/w | 99.87% |
Tsis lees paub: tshwj tsis yog tias tau teev tseg, tsab xov xwm kev paub luam tawm los ntawm lub vev xaib no los ntawm Is Taws Nem thiab feem ntau yog siv los txhawb kev sib pauv kev kawm thiab kev kawm. Nws tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov ua tib zoo tshuaj xyuas nws. Yog tias koj xav tias muaj kev ua txhaum cai hauv tsab xov xwm no, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab kev pabcuam ntawm lub vev xaib no.
Nco tseg: Tag nrho cov tebchaw muaj kev pheej hmoo. Thov nrog koj tus kws qhia ntawv, kws kho mob, lossis lwm tus kws tshawb fawb ua ntej siv. Cov khoom no tsis yog siv los kuaj xyuas, tiv thaiv lossis kho cov kab mob, tab sis tsuas yog siv rau kev tshawb fawb tshawb fawb. Lub tuam txhab tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.
Yog tias koj xav tau kev pab, thov hu rau peb
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