Khoom Description
Tofacitinib Citrate hmoovyog ib qho citrate uas muaj tofacitinib sib xyaw nrog cov molar sib npaug ntawm tofacitinib thiab citric acid. Nws yog siv los kho mob nruab nrab mus rau hnyav rheumatoid mob caj dab. Nws muaj EC 2.7.10.2 (tsis yog cov protein tshwj xeeb tyrosine kinase) inhibitor thiab anti-rheumatic nyhuv.
Tofacitinib Citrate hmoov, tshuaj muaj npe 3-[(3R, 4R)-4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl) amino]piperidin-1-yl]-3-oxopropionitrile citrate, yog ib hom tshiab ntawm Janus kinase inhibitor tsim los ntawm Pfizer, Tebchaws Asmeskas. Nws tau pom zoo los ntawm US FDA rau kev lag luam thaum lub Kaum Ib Hlis 2012 raws li lub npe lag luam Xeljanz. Cov khoom no tuaj yeem siv ua ke nrog methotrexate los kho cov mob rheumatoid mob caj dab uas tsis ua haujlwm zoo rau cov qog necrosis factor inhibitors.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
COA
| Cov khoom kuaj | Specifications | Cov txiaj ntsig |
| Yam ntxwv | Dawb crystalline hmoov | Ua raws |
| Kev Taw Qhia A | IR, UV conform | Ua raws |
| Kev Qhia B | Yuav tsum ua raws | Ua raws |
| Tus nqi PH | Ntawm 3.9 rau 7.1 | 5.3 |
| Dej | Ntawm 5.7% ~ 6.8% | 6.5 |
| Cov hlau hnyav | Tsis ntau tshaj 0.002% | <0.001% |
| Chlorides | Tsis ntau tshaj 0.018% | 0.00% |
| Melting ntau | Ntawm 48.5 degree thiab 52 degree | 49.2 degree ~ 50.4 degree |
| Cov kab mob endotoxin | Tsis ntau tshaj 0.2 | Ua raws |
| Kev kuaj tsis muaj menyuam | Ua tau raws li qhov yuav tsum tau ua | Ua raws |
| Kev txwv ntawm Propanolamine | Tsawg dua lossis sib npaug rau 0.025% | Ua raws |
| Kev txwv ntawm Phosphate | Tsawg dua lossis sib npaug rau 0.01% | Ua raws |
| Residual kuab tshuaj | Cawv: tsis ntau tshaj 0.5% | 100 ppm |
| Xaus | Ua raws li tus qauv kev lag luam | |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
Daim ntawv thov
Tofacitinib Citrate hmoov(Xeljanz) yog ib qho kev kho mob rau cov neeg laus uas muaj mob nruab nrab mus rau mob hnyav rheumatoid mob caj dab (RA), active psoriatic mob caj dab, ankylosing spondylitis, nruab nrab mus rau hnyav ulcerative colitis, thiab cov me nyuam hnub nyoog 2 xyoos thiab laus dua nrog active multiarticular juvenile idiopathic mob caj dab. Nws ua haujlwm los ntawm kev thaiv cov enzyme hu ua Janus kinases (JAKs). jak plays lub luag haujlwm hauv kev sib koom ua ke, uas tuaj yeem ua rau mob, o thiab txhav. Cov khoom no feem ntau siv yog tias tus neeg mob tsis teb zoo rau lwm cov khoom xws li methotrexate thiab qog necrosis factor inhibitors.
Hauv xyoo 2012, US FDA tau pom zoo Tofacitinib rau kev kho mob rheumatoid mob caj dab.
Muaj nuj nqi
1.Tofacitinib Citrate hmoov(477600-75-2) API yog Jak kinase inhibitor siv los kho mob rheumatoid mob caj dab.
2.Tofacitinib Citrate hmoovyog daim ntawv citrate ntawm tofacitinib, tseem hu ua CP-690550, Tasocitinib, Suav lub npe Tofacitinib.
3.Tofacitinib Citrate hmoovyog lub zog muaj zog ntawm tes permeability inhibitor ntawm JAK3 nrog IC50 ntawm 1 nM, uas tuaj yeem cuam tshuam JAK1 (IC50=20} nM) thiab JAK2 (IC50=112 nM). Piv nrog JAK2WT hlwb, tofacitinib muaj zog tiv thaiv kev loj hlob thiab pro-apoptotic kev ua ub no tiv thaiv JAK2V617F hlwb. Hauv vivo kev kho cov nas nrog leukemia, tofacitinib tuaj yeem txo cov qe ntshav dawb thiab ua rau apoptosis ntawm leukemia hlwb. Tofacitinib tuaj yeem cuam tshuam qhov sib xyaw lymphocyte teb (MLR) (IC{12}} nM) thiab ua kom muaj sia nyob ntawm xenografted qog nas. Nws tuaj yeem siv los tiv thaiv kev hloov pauv hauv nruab nrog cev thiab txo cov tsos mob ntawm cov kab mob autoimmune xws li mob caj dab rheumatoid (RA) thiab lwm yam kab mob autoimmune.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
vim li cas xaiv peb
Peb ua raws li lub hauv paus ntsiab lus ntawm "cov neeg siv khoom ua ntej, kev ncaj ncees ua ntej", thiab ib txwm muab cov neeg siv khoom zoo thiab cov khoom siv tau zoo thiab cov kev pabcuam zoo. Xaiv kev ncaj ncees. Xaiv lub neej noj qab nyob zoo!
Nrog peb cov kev siv zog tas mus li thiab kev pabcuam zoo, peb cia siab tias yuav tsim kev koom tes ntev thiab kev loj hlob zoo nrog cov neeg siv khoom thiab muab sijhawm rau peb. Peb ntseeg tias peb yuav txaus siab rau koj nrog thawj-chav kawm zoo, nyab xeeb thiab xa khoom sai thiab txaus siab rau kev pab cuam tom qab muag.
Peb lub Hoobkas
Pob
Shipping Txoj Kev
|
Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
|
3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, thiab cov neeg muas zaub nyob rau hauv cov teb chaws Europe thiab Amelikas tuaj yeem txaus siab xa cov khoom ncaj qha los ntawm ob qhov chaw no. |
|
7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
|
|
15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
Tsis lees paub: Tag nrho cov khoom lag luam (cov khoom siv tsis raug cai) cov duab tau muab coj los ua zoo, tab sis vim yog lub zog ntawm lub teeb (lub sijhawm sib txawv, lub teeb tom qab sib txawv), txoj kev tua, cov khoom siv sib txawv thiab lwm yam, tej zaum yuav muaj qee qhov sib txawv ntawm qhov daim duab thiab cov xim tiag tiag, cov khoom xim, thov coj cov nyhuv tiag tiag, cov xim sib txawv ntawm cov khoom tsis yog cov teeb meem zoo.
Nco tseg: Nco ntsoov sab laj nrog tus kws kho mob uas tsim nyog ua ntej noj cov tshuaj tshiab. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho lossis tiv thaiv txhua yam kab mob.Thaum lub sijhawm yuav khoom, tus neeg yuav khoom thoob ntiaj teb pom zoo xav tias muaj kev pheej hmoo ntawm txhua yam khoom tuaj txog. Peb tsis tuaj yeem hloov cov khoom ploj lossis raug kaw. Ua ntej xa cov khoom, koj yuav tsum paub meej tias koj pom zoo rau cov nqe lus no.Qhov no tsuas yog kev pom zoo koob tshuaj raws li peb tus kheej kev paub thiab cov ntaub ntawv pov thawj. Peb pom zoo kom koj ua koj tus kheej kev tshawb fawb ua ntej siv cov khoom no.
Cim npe nrov: tofacitinib citrate hmoov cas 540737-29-9, Suav teb, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua hauv Suav teb