Tropinone hmoov CAS 532-24-1

Khoom Taw Qhia

TxogTropinone hmoov: nplooj ncav cuag qhov siab tshaj plaws alkaloid cov ntsiab lus thaum cov nroj tsuag yog budding thiab flowering, thiab cov hauv paus hniav muaj tshuaj lom tshaj plaws nyob rau hauv lub kawg ntawm cov nroj tsuag lub sij hawm (Raetsch, 2005). Belladonna nectar yog hloov los ntawm muv mus rau hauv zib mu uas kuj muaj tropane alkaloids (Hazlinsky, 1956). Lawv ib txwm tau los ntawm kev rho tawm los ntawm nplooj ntawm cov nroj tsuag kab lis kev cai. Ib qho kev xaiv rau kev rho tawm ntawm cov ntaub so ntswg tuaj yeem yog kev siv cov kab lis kev cai ntawm tes (Fuyita thiab Tabata, 1987).
Tropane yog bicyclic amine uas muaj pyrrolidine thiab piperidine nplhaib sib koom ib qho nitrogen atom thiab ob carbon atoms. Nws yog cov qauv tsim ntawm tag nrho cov tropane alkaloids. Txhua qhov chaw ntawm cov nroj tsuag muaj tropane alkaloids ("Tsoomfwv rau Veterinary Medicinal Products, A. belladonna, Summary Report" European Agency for the Evaluation of Medicinal Products.
1998. Archived los ntawm tus thawj ntawm 2006-07-18. Retrieved 2008-07-08.) Cov hauv paus hniav muaj txog li 1.3%, nplooj 1.2%, stalks 0.65%, paj 0.6%, ripe berries 0.7%, thiab noob 0.4% tropane alkaloids; Txawm li cas los xij, nws tau pom tias tropane alkaloid biosynthesis tau cuam tshuam nrog kev sib txawv hauv paus (Endo thiab Yamada, 1985). Vim li no, cov hauv paus plaub hau tsim muaj ib qho kev nthuav qhia los tsim cov metabolites theem nrab (Hamill li al., 1987; Verpoorte li al., 1999).

Tropane tau tsim los ntawm kev txo qisTropinone hmoovlos ntawm kev siv ptO2 nyob rau hauv lub xub ntiag ntawm 2 N HCl (Scheme 10.4). Lub synthesis ntawm tropinone ua los ntawm Robinson tau suav hais tias yog ib qho classic hauv tag nrho cov synthesis (Birch, 1993) vim nws txoj kev yooj yim thiab biomimetic.Tropinone hmoovyog ib tug bicyclic molecule, tab sis cov reactants siv nyob rau hauv nws cov kev npaj yog haum yooj yim: succinaldehyde, methylamine, thiab acetonedicarboxylic acid (los yog txawm acetone). Cov synthesis yog ib qho piv txwv zoo ntawm biomimetic cov tshuaj tiv thaiv lossis biogenetic-type synthesis vim biosynthesis ua rau siv tib lub tsev thaiv. Nws kuj qhia tau hais tias muaj kev cuam tshuam tandem hauv ib lub lauj kaub synthesis.

Tropinone hmoov Daim duab	Tropinone MF

Khoom siv

Lub mechanism ntawm cov tshuaj tiv thaiv yog:
1: Nucleophilic ntxiv ntawm thawj amine rau aldehyde, ua raws li lub cev qhuav dej los tsim imine;
2: Nucleophilic ntxiv nyob rau hauv lub imine molecule los tsim thawj lub nplhaib;
3: Intermolecular Mannich cov tshuaj tiv thaiv ntawm lub enolate anion thiab acetone dicarboxylate anion
4: Lub cev qhuav dej los tsim ib qho tshiab enolate anion thiab imine tshiab;
5: Intramolecular Mannich cov tshuaj tiv thaiv los tsim lub nplhaib thib ob;
6: Tshem tawm ntawm ob pawg carboxyl los tsimTropinone hmoov;

 

 

cov khoom siv thev naus laus zis

01.

Tropinone hmoovyog ib tug tropane alkaloid, feem ntau nyob rau hauv daim ntawv ntawm koob-zoo li tus crystals, siv raws li ib tug intermediate rau cov synthesis ntawm atropine sulfate. Nws yog ib qho alkaloid molecule tsim nyog hais nyob rau hauv keeb kwm ntawm organic synthesis. Nws yog npaj los ntawm cua sov cyclization ntawm succinaldehyde nrog methylamine thiab acetone dicarboxylic acid nyob rau hauv alkaline tej yam kev mob.

02.

Tsis ntev los no, KC Nicolaou tau siv ntau tshaj ntawm 2-iodoacylbenzoic acid (IBX) reagent thiab ib lub lauj kaub cov tshuaj tiv thaiv rau oxidize cov cawv (cycloheptanol) mus rau ketone thaum tsim cov qauv , -unsaturated. Ntxiv ntxiv ntawm methylamine tuaj yeem ncaj qha tsim tropinone thiab nws cov analogues. Cov txheej txheem tshuaj tiv thaiv yog qhia hauv daim duab.

Khoom Specification

Yuav ua li cas kom tau cov qauv ntawmTropinone hmoov?

Txais tos xa ib qho kev nug rausunny@faithfulbio.comtxhua lub sijhawm rau tus qauv dawb yog tias koj xav tau APITropinone hmoov.

Qhov zoo tshaj plaws Tropinone hmoov Chaw tsim tshuaj paus thiab tsum

Faithfulbio muaj kev paub dhau los hauv kev xa tawm cov ntaub ntawv raw thiab tau tsim kev sib raug zoo thiab kev koom tes ntev nrog peb cov neeg siv khoom. Peb ib txwm muab cov khoom zoo thiab kev pabcuam ua ntej. Yog tias koj muaj cov khoom siv raw khoom xav tau, thov hu rau peb. Peb tuaj yeem lees paub qhov kev txiav txim nrog koj raws li koj qhov yuav khoom ntau. Peb kuj txhawb peb txoj kev koom tes thawj zaug pib los ntawm cov qauv. Tsis tas li ntawd, peb txoj kev thauj mus los sai thiab nyab xeeb kuj ua rau koj tshem tawm cov teeb meem ntawm kev lis kev cai.

Peb muaj kev ntseeg siab ntawm peb cov khoom zoo, tab sis yog tias muaj teeb meem tom qab muag, peb yuav teb sai li sai tau thiab daws lawv nrog koj txoj hauv kev zoo tshaj plaws.

Vim Li Cas Xaiv FaithfulbioTropinone hmoov?

Faithfulbio tshwj xeeb hauv Tropinone hmoov rau ntau xyoo, peb muab cov khoom lag luam ntawm tus nqi sib tw, thiab peb cov khoom yog qhov zoo tshaj plaws, vim tias peb nruj heev rau kev tsim khoom thiab kev sim, thiab muaj kev ua tiav thiab kev loj hlob. Tsis tas li ntawd, peb cov neeg ua haujlwm Cov lus hais rau cov khoom muaj kev sib tw heev.

Muaj ntau txoj kev xa khoom rau koj xaiv

ua siab zoo ceeb toom:SivTropinone hmoovrau kev tshawb fawb nkaus xwb. Txhua lub tebchaw muaj kev pheej hmoo. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv. Tsis tas li ntawd, cov lus piav qhia saum toj no ntawm qhov sib xyaw yog los ntawm cov ntaub ntawv online. Yog tias muaj kev ua txhaum cai, thov hu rau peb kom tshem tawm.

Yuav Qhov twg Yuav Tropinone hmoov?

Cia li xa email rausunny@faithfulbio.com, lossis xa koj qhov yuav tsum tau ua hauv daim ntawv hauv qab, peb muaj kev pabcuam txhua lub sijhawm!

Cim npe nrov: tropinone hmoov cas 532-24-1, Suav teb, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua nyob rau hauv Tuam Tshoj