Biphalin Trifluoroacetate ntsev CAS 83916-01-2

Biphalin trifluoroacetate ntsev CAS 83916-01-2Nws yog ib qho nquag siv hluavtaws opioid peptide agonist, dimeric enkephalin analog. Nws feem ntau yog tsim los ua ib qho trifluoroacetate los txhim kho cov dej solubility thiab kev ruaj ntseg, thiab yog cov cuab yeej tseem ceeb hauv kev kho mob neuropharmacology, mob mechanisms, thiab kev tshawb fawb neuroprotective. Cov tshuaj no yog cov hmoov dawb lyophilized nrog kev tshawb fawb - qib purity feem ntau Ntau dua lossis sib npaug li 97% (HPLC). Nws yuav tsum tau muab cia rau ntawm -20℃nyob rau hauv ib qho chaw qhuav, tiv thaiv lub teeb kom ntseeg tau cov qauv thiab kev ua haujlwm ruaj khov.

Nws cov qauv molecular muaj ob enkephalin pharmacophores, tso cai rau nws khi ib txhij nrog siab affinity rau μ, δ, thiab κ opioid receptors ntawm nanomolar qib. Nws lub zog analgesic yog qhov siab dua li morphine, nthuav tawm cov txiaj ntsig zoo rau cov tsiaj hauv cov qauv ntawm qhov mob hnyav, mob neuropathic, thiab mob ntev, nrog lub sijhawm ua haujlwm zoo dua. Ntxiv nrog rau nws cov khoom siv tshuaj tua kab mob, Biphalin trifluoroacetate ntsev kuj nthuav tawm cov haujlwm tiv thaiv kab mob. Nyob rau hauv cov qauv ntawm cerebral ischemia, mob stroke, thiab excitotoxicity, nws zoo txo ​​infarct ntim, alleviates cerebral edema, thiab inhibits neuronal apoptosis. Nws cov nyhuv tiv thaiv tuaj yeem thaiv los ntawm opioid receptor antagonist naltrexone, qhia tias nws qhov kev ua haujlwm nyob ntawm txoj kev opioid receptor. Nyob rau tib lub sijhawm, cov tshuaj no tseem muaj ntau yam teebmeem lom, nrog rau kev tiv thaiv -inflammatory, immunomodulatory, antiproliferative, thiab antiviral zog. Nws tuaj yeem cuam tshuam qhov kev tso tawm ntawm pro- cov yam ntxwv mob xws li TNF- thiab IL-1 , thiab tswj cov lus teb hauv nruab nrab thiab sab hauv.