Cyclo(-Arg-Gly-Asp-D-Ph-Lys) CAS 161552-03-0

CYCLO (RGDFK) yog ib qho cyclic pentapeptide tsim los ntawm kev sib txuas arginine (R), glycine (G), aspartic acid (D), D-phenylalanine (f), thiab lysine (K) los ntawm peptide bonds los tsim cov qauv cyclic. Kev tshawb fawb qhia tias cov qauv cyclic txhim kho nws txoj kev ruaj ntseg, ua rau nws tsis tshua muaj kev cuam tshuam rau protease degradation nyob rau hauv ob qho tib si hauv vivo thiab hauv vitro ib puag ncig. CovCyclo(-Arg-Gly-Asp-D-Ph-Lys)muab los ntawm peb lub tuam txhab yog ib tug dawb los yog yuav luag dawb crystalline hmoov uas yog heev soluble nyob rau hauv dej. Cov tub ntxhais cyclic peptide nyob rau hauv nws yog RGD ib ntus, uas tuaj yeem khi rau cov receptors xws li integrin v 3 thiab v 5, ua lub luag haujlwm tseem ceeb hauv cov txheej txheem physiological thiab pathological xws li cell adhesion, migration, thiab angiogenesis.

Dab tsi yog cov tshuaj siv tshuaj ntawm kev ua ntawm Cyclo (-Arg-Gly-Asp-D-Phe-Lys)?

CYCLO (ARG-GLY-ASP-D-PHE-LYS)yog ib qho zoo thiab xaiv integrin v 3 inhibitor nrog tus nqi IC50 ntawm 0.94 nM. Nws tshwj xeeb khi rau integrin receptors ntawm lub xov tooj ntawm tes los ntawm RGD ib ntus, thaiv kev cuam tshuam ntawm integrin thiab nws cov ligands ntuj, yog li inhibiting qog angiogenesis, qog cell proliferation, tsiv teb tsaws, thiab ntxeem tau. Piv rau linear RGD peptides, cov qauv cyclic ua rau nws conformation ntau nruj, txhim khu nws affinity thiab selectivity rau integrin receptors. Kev sim tshuaj lom neeg tau pom tias CYCLO (RGDFK) cyclic peptide muaj cov haujlwm lom neeg hauv qab no: 1) tshwj xeeb khi rau integrin v 3 thiab v 5 nrog kev sib raug zoo siab (Kd kwv yees li 10⁻⁹ M); 2) inhibition ntawm qog angiogenesis thiab qog cell invasion thiab metastasis; 3) txhawb nqa cov tshuaj sib xyaw ntawm cov qog nqaij hlav los ntawm receptor-kho endocytosis; 4) cov qauv cyclic muab siab dua nyob rau hauv vivo stability thiab tsis kam mus rau protease degradation.

Daim ntawv thov teb ntawm CYCLO (ARG-GLY-ASP-D-PHE-LYS) nyob qhov twg?

Cyclo(-RGDfK) yog ib qho kev xaiv cyclic peptide inhibitor ntawm integrin_alpha_v_beta_3, uas tuaj yeem siv tsis tau tsuas yog hauv kev tshawb fawb kev tshawb fawb tab sis kuj tuav nws tus kheej hauv kev lag luam tshuaj.
1. Daim ntawv thov ntawmCYCLO (RGDFK)hauv kev kho mob qog nqaij hlav.
1) Targeted Drug Delivery: Thaum ua ke nrog cov tshuaj tiv thaiv -cov khoom siv qog noj tshuaj raws li lub hom phiaj ligand, c(RGDfK) ntawm qhov tsim nyog concentration ua rau qhov tseeb tsub zuj zuj ntawm cov tshuaj tiv thaiv -cov qog ua haujlwm ntawm cov qog nqaij hlav, yog li txhim kho cov txiaj ntsig kho mob thiab txo cov kev mob tshwm sim siab: Moegrade 4} Cov kev mob tshwm sim siab heev . 2 Cyclo (-RGDfK) TFA tuaj yeem sau cov xov tooj cua isotopes (xws li Ga-68, Cu-64) los yog cov tshuaj fluorescent siv rau hauv cov tswv yim duab xws li PET thiab SPECT, ua kom yooj yim rau kev kuaj mob ntxov thiab kev soj ntsuam xyuas cov qog nqaij hlav zoo. 3) Cov tshuaj Mov CYLO: API (ARG-GLY-ASP-D-PHE-LYS) tuaj yeem hloov kho qhov chaw ntawm cov neeg nqa khoom xws li liposomes thiab nanoparticles, txhim kho lub hom phiaj muaj peev xwm ntawm cov tshuaj rau cov qog hlwb. 4) Anti-}cov tshuaj tiv thaiv kab mob, los yog cov tshuaj nanoparticles: anti-cov tswv yim qog nqaij hlav feem ntau tau kawm los ntawm kev sib tw rau cov chaw sib koom ua ke. Cyclo(-Arg-Gly-Asp-D-Phe-Lys) yog tam sim no lub ntsiab lus tshawb fawb tshiab.
2. Daim ntawv thov ntawm CYCLO (RGDFK) hauv cov ntaub so ntswg engineering.
Nws tuaj yeem siv los hloov kho qhov chaw ntawm biomaterials, tswj kev sib cuam tshuam ntawm cov hlwb thiab cov ntaub ntawv, thiab txhawb cov ntaub so ntswg kho thiab rov tsim dua tshiab. Hauv biomaterial science,siab-zoo Cyclo(-Arg-Gly-Asp-D-Phe-Lys)tuaj yeem khi rau integrin receptors los ntawm RGD ib ntus, coj cov cell adhesion, proliferation, thiab sib txawv ntawm cov khoom nto. Qhov no muaj peev xwm siv tau hauv thaj chaw xws li pob txha pob txha engineering, kho pob txha mos, thiab cov hlab ntsha rov tsim dua tshiab.

Dab tsi yog qhov zoo ntawm Cyclo(-Arg-Gly-Asp-D-Phe-Lys)?

Piv rau linear RGD peptides, CYCLO (RGDFK) muaj cov txiaj ntsig hauv qab no:
1) Kev ruaj ntseg siab: Cov qauv cyclic txo cov reactivity ntawm cov pab pawg davhlau ya nyob twg ntawm peptide saw, ua rau nws tsis tshua muaj kev cuam tshuam rau protease degradation nyob rau hauv vivo thiab hauv vitro ib puag ncig, cuam tshuam nws ib nrab -lub neej; 2) High affinity: Lub cyclic conformation enables RGD ib theem zuj zus los txais yuav ib lub kaum ntse ntse nyob rau hauv qhov chaw, txhim kho nws affinity thiab selectivity rau integrin receptors; 3) Multifunctionality: Cov amino pawg ntawm cov lysine sab saw muab cov chaw ua haujlwm rau kev hloov kho tom ntej, tso cai rau kev sib txuas ntawm fluorescent dyes, radioactive isotopes, tshuaj molecules, lossis cov cab kuj; 4) Kev xaiv siab: Nws nthuav tawm qhov tshwj xeeb rau integrin v 3 thiab v 5, txo qhov tsis yog - tshwj xeeb khi. Raws li kev tshawb fawb peptide tam sim no, piv rau ntuj L-amino acids, D-amino acids tuaj yeem txhim kho kev ruaj ntseg ntawm peptides hauv cov kua hauv lub cev thiab txo tus nqi ntawm cov enzyme degradation, yog li txuas ntxiv lub sijhawm ua haujlwm zoo ntawm peptides. Lub nplhaib phenyl ntawm D-phenylalanine kuj tseem ua rau muaj kev cuam tshuam ntawm hydrophobicity ntawm lub molecule, tswj kev ruaj ntseg ntawm lub nplhaib, thiab cuam tshuam rau hydrophobic kev cuam tshuam nrog receptors. Kev taw qhia ntawm D-phenylalanine (f) rauc(RGDfK) peptide hmoovkhaws cov yam ntxwv saum toj no, ua rau peptide conformation nruj dua, thiab txhim kho nws cov kev xaiv rau v3 integrin.

Muaj ntau txoj kev xa khoom rau koj xaiv

Peb lub zog:

Peb lub tuam txhab tau dhau los ntawm FDA thiab ISO19001 kev tswj hwm qhov system ntawv pov thawj. Thiab peb muaj kev koom tes nrog kev cog lus nrog ntau lub Hoobkas thiab chaw kuaj hauv Suav teb, Peb lub tuam txhab tuaj yeem muabCyclo(-Arg-Gly-Asp-D-Phe-Lys) peptide hmoovthiab lwm yam ntawm tus nqi zoo dua. Yog tias koj txaus siab, thov sau ib tsab ntawv.
Peb tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev thauj mus los, tab sis kuj txhawb ntau txoj kev them nyiaj, txawm tias koj siv nyiaj US, euros, Australian las, lossis cov nyiaj hauv zos los ntawm Singapore, Malaysia, Thaib, thiab lwm yam. Peb kuj tuaj yeem txhawb cov txiaj ntsig hauv zos hauv cov cheeb tsam thiab cov tebchaws no. Tsis tas li ntawd, peb kuj txhawb nqa cov npav hauv txhab nyiaj (credit cards, thiab lwm yam) rau kev them nyiaj.

FAQ:

Q1: Nws ruaj ntseg li cas? cov
CovCyclo(-Arg-Gly-Asp-D-Phe-Lys) peptidemuaj biocompatibility zoo thiab tau pom muaj kev nyab xeeb zoo hauv vitro thiab kev sim tsiaj. Txawm li cas los xij, vim nws lub hom phiaj ntawm integrin receptors, nws tuaj yeem cuam tshuam rau cov cell adhesion thiab cov txheej txheem tsiv teb tsaws. Hauv kev tshawb fawb preclinical, nws yog qhov yuav tsum tau ntsuas nws qhov cuam tshuam rau cov ntaub so ntswg ib txwm, tshwj xeeb tshaj yog ntawm angiogenesis thiab kho qhov txhab.

Q2: Yuav khaws nws li cas?
Nws raug nquahu kom muab tso rau hauv qhov chaw txias txias (-20 ° C), kom tsis txhob muaj lub teeb thiab noo noo, kom muaj kev ua haujlwm thiab ruaj khov ntawm CYCLO (RGDFK) peptide. Yog tias tsis siv, nws yuav tsum tau muab khaws cia rau hauv nws qhov ntim thawj zaug kom tsis txhob muab faib rau lwm lub ntim. Lub ntim yuav tsum raug kaw tam sim tom qab siv txhua zaus. Raws li qhov tsim nyog khaws cia, cov khoom txee lub neej feem ntau yog 24 lub hlis.

Q3: Dab tsi yog cov yam ntxwv ntawmCYCLO (RGDFK)piv rau lwm yam RGD peptides? cov
Piv nrog rau linear RGD peptides, CYCLO (RGDFK) muaj kev ruaj ntseg thiab affinity ntau dua; Piv nrog rau lwm yam cyclic RGD peptides xws lic (RGDyK), kev taw qhia ntawm D-phenylalanine ua rau nws cov kev sib raug zoo nruj dua thiab muaj kev xaiv ntau dua rau v 3 integrin. Tsis tas li ntawd, lysine sab saw amino pawg muab qhov chaw yooj yim rau kev hloov kho tom ntej, ua rau nws muaj txiaj ntsig zoo hauv kev ua haujlwm.

Tsis lees paub: Cov ntaub ntawv luam tawm ntawm lub vev xaib no los ntawm Is Taws Nem, tsis tau txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm cov ntsiab lus. Thov ua tib zoo saib kom paub qhov txawv. Tsis tas li ntawd, cov khoom muab los ntawm peb lub tuam txhab tsuas yog siv rau kev tshawb fawb tshawb fawb. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.

Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais, thov hu rau peb los ntawmEmail :sales6@faithfulbio.com . Peb pab neeg tau cog lus los ua kom tiav kev txaus siab ntawm cov neeg siv khoom.

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