DSIP CAS 62568-57-4

DSIPyog peptide tsim los ntawm cuaj amino acids, thiab Nws cov amino acid sequence yog: Trp-Ala-Gly-Gly-ASP-Ala-SER-Gly-Glu(WAGGDASGE); Nws tau raug pov thawj hauv qee qhov kev tshawb fawb tias nws yog neuropeptide nrog antioxidant thiab tiv thaiv kev ntxhov siab. Nws yog siv los txhim kho thiab txhawb kev pw tsaug zog hauv tsev kho mob, thiab cov nyhuv yog qhov zoo tagnrho.

Khoom Specification

Delta-Pleep Inducing Peptide yog dab tsi?

Xyoo 1974, pab pawg Schoenenberger-Monnier hauv Switzerland thawj zaug cais Delta Pw tsaug zog Inducing Peptide los ntawm cov hlab ntsha hlwb ntawm luav hauv induced pw tsaug zog. Cov kws tshawb fawb kuj tau lees paub tias tus luav pw tsaug zog muaj qee yam ua rau nws.
Nyob rau hauv kev tshawb fawb ntxiv, thaum lub caishuv dsipcov khoom tau muab tso rau hauv nruab nrab ntawm lub hlwb ventricle ntawm tus neeg tau txais luav (pw tsaug zog luav), cov kws tshawb fawb pom tias nws yuav ua rau cov ntxaiv nthwv dej thiab Delta EEG kev ua haujlwm, thiab txo cov kev ua haujlwm ntawm lub cev ntawm luav. Txawm li cas los xij, tau muaj qhov tsis sib haum xeeb hauv kev kawm txog lub ntsiab lus no. Txawm hais tias nws muaj peev xwm ua kom muaj zog qeeb qeeb hauv cov luav, cov noob caj noob ces ntawm peptide tsis tau pom nyob rau hauv luav (xws li ib qho receptor lossis precursor peptide). Tom qab ntawd, ib yam khoom zoo ib yam li DSIP tau pom hauv tib neeg cov kua mis.

DSIP puas tuaj yeem hla cov ntshav-hlwb barrier yooj yim?

CovDelta pw tsaug zog inducing peptideyog ib tug linear cuaj tus tswv cuab luv luv peptide (raws li qhia hauv daim duab), thiab qhov hnyav molecular ntawm DSIP yog amphiphilic peptide nrog ib qho hnyav molecular ntawm 850 daltons. Cov peptide no tuaj yeem ua raws li qhov txwv kev ntxhov siab thiab tuaj yeem muaj cov teebmeem antioxidant. Hauv kev sim nrog lwm yam tsiaj, peb pom tias nws tuaj yeem txhim kho kev pw tsaug zog thiab ua kom tsaug zog latency luv. Hauv kev soj ntsuam kev tshawb fawb siv tib neeg los ua tus neeg nqa khoom, nws tau pom tias ntuj DSIP tuaj yeem txo cov mob migraines, vasomotor mob taub hau, thiab lwm yam. Nyob rau tib lub sijhawm, nws tuaj yeem txhawb nqa qhov tso tawm ntawm luteinizing hormone kom nce qib testosterone, tsis ncaj qha los pab txo cov tsos mob ntawm tus mob. Nws tau lees paub tias kev siv DSIP los kho cov tsos mob ntawm kev haus cawv thiab qee yam khoom yav tom ntej yog qhov kev xaiv zoo tshaj plaws. Ntxiv rau dsip, peb lub tuam txhab tseem tuaj yeem muab kev pab ntxiv rau koj cov tshuaj tiv thaiv tshem tawm. Yog tias koj xav tau kev pab, thov hu rau peb ntawm email:email: sales6@faithfulbio.com

Vim li cas Delta Pw Tsaug Zog Inducing Peptide hla cov ntshav-hlwb teeb meem nrog lub cev tag nrho?

Ntshav-brain barrier yog hais txog kev thaiv ntawm plasma thiab hlwb hlwb tsim los ntawm lub hlwb capillary phab ntsa thiab glial hlwb thiab nruab nrab ntawm cov ntshav thiab cerebrospinal kua tsim los ntawm choroid plexus, uas tuaj yeem tiv thaiv qee yam tshuaj (feem ntau tsis zoo) los ntawm kev nkag mus rau lub hlwb los ntawm cov ntshav. Nws ua zoo li ib pab neeg ntawm cov neeg ua haujlwm ruaj ntseg ntawm lub dav hlau, thiab txhua tus neeg uas tsis ua raws li cov kev cai tsis tuaj yeem hla. Cov kev tsis sib xws no suav nrog feem ntau peptide molecules.
Thaum cov kws tshawb fawb tau kawm txog lub hauv paus ntawmδ pw tsaug zog-inducing peptide, lawv xav tsis thoob thaum pom tias DSIP tuaj yeem hla cov ntshav-hlwb thaiv kab mob los ntawm kev tshuaj ntsuam radioimmunoassay.
Nyob rau hauv tus txheej txheem ntawm teb cov lus nug txog lub mechanism uas DSIP hla cov ntshav-hlwb barrier, uas yog suav hais tias yog ib tug "natural barrier" los ntawm feem ntau polypeptide molecules, cov kws tshawb fawb pom tau hais tias txawm hais tias cov peptides yog piv rau qhov hnyav molecular, lawv muaj peev xwm ua tau. nkag mus rau hauv nruab nrab paj hlwb txawv heev. Nyob rau hauv cov ntaub ntawv ntawm qhov ntau thiab tsawg molecular, xws li ib tug loj sib txawv nyob rau hauv kev thauj mus los ceev qhia tau hais tias molecules tsis hla cov ntshav-hlwb barrier los ntawm kev cia siab rau passive diffusion mechanism. Ntawm qhov tsis sib xws, rog solubility yog qhov ntsuas tseem ceeb ntawm tus nqi nkag mus rau hauv lub hlwb: ntau peptides tuaj yeem hla cov ntshav-hlwb teeb meem los ntawm kev tsim txiaj ntawm lawv cov lipophilicity siab. Qhov no yuav yog lwm qhov kev zam rau Lipinski 5 txoj cai. (Molecules nrog molecular hnyav dua 500 Da tuaj yeem hla cov ntshav-hlwb barrier zoo dua cov uas muaj molecular hnyav dua 500 Da.)
Txog rau tam sim no, cov khoom loj tshaj plaws hla cov ntshav-hlwb teeb meem los ntawm cov txheej txheem tsis txaus (cov tshuaj nkag mus rau hauv lub hlwb los ntawm kev thauj mus los lossis tshwj xeeb receptor-mediated channels, es tsis yog passive diffusion mechanism) yog CINC-1 (ib cytokine koom nrog hauv kev tswj kev mob thiab kev tiv thaiv kab mob), nrog rau qhov hnyav molecular ntawm 7.8 kDa.

Dab tsi yog qhov kev tshawb fawb tshiab ntawm kev sib cuam tshuam thiab kev ua haujlwm ntawm cov khoom no?

Cov tshuaj no muaj nyob rau hauv lub hypothalamus, limbic system, pituitary caj pas thiab ntau yam peripheral kab mob, cov ntaub so ntswg thiab lub cev kua nyob rau hauv cov ntaub ntawv dawb thiab ua ke.
Nyob rau hauv lub caj pas pituitary, nws cuam tshuam nrog ntau peptide thiab tsis yog peptide mediators, xws li adrenocorticotropic hormone zoo li intermediate peptide (CLIP), adrenocorticotropic hormone (ACTH), melanocyte stimulating hormone (MSH), thyroid stimulating hormone (TSH) thiab melanin concentrating. Cov tshuaj hormones (MCH).
Nws muaj ntau nyob rau hauv cov hnyuv secretory cells thiab pancreas thiab ua ke nrog glucagon.
Hauv vitro, vim qhov kev ua ntawm cov aminopeptidase-zoo li enzymes, nws tau pom tias nws cov molecular stability yog tsawg thiab nws ib nrab-lub neej tsuas yog 15 feeb. Qee cov kws tshawb fawb xav tias cov tshuaj no tuaj yeem ua ke nrog cov cab kuj muaj protein ntau hauv vivo los tiv thaiv kev degradation, los yog muaj nyob rau hauv ib feem ntawm cov loj precursor molecules, tab sis tam sim no tsis muaj cov qauv los yog cov noob ntawm no precursor tau pom.
Tam sim no, qhov nrov inference yog tiasDSIPcuam ​​tshuam nrog cov khoom ntawm MAPK cascade, uas yog homologous rau glucocorticoid-induced leucine zipper (GILZ) thiab tej zaum yuav raug tswj los ntawm glucocorticoid.
Hauv kev sim tshuaj, DSIP muaj ntau lub luag haujlwm: nws tuaj yeem txo cov qib ntawm corticotropin yooj yim thiab tiv thaiv nws qhov kev tso tawm; Txhawb kev tso tawm ntawm luteinizing hormone (LH); Txhawb kev tso tawm ntawm kev loj hlob hormone tso tawm cov tshuaj hormones thiab kev loj hlob hormone, thiab inhibit qhov tso tawm ntawm somatostatin.
Hauv cov txheej txheem physiological, nws tuaj yeem siv los ua lub siab txwv qhov ua rau normalize ntshav siab thiab myocardial contraction.
Tej zaum nws yuav muaj kev cuam tshuam ncaj qha lossis tsis ncaj rau lub cev kub thiab txo qis hypothermia. Nws tuaj yeem txhim kho oxidative phosphorylation efficiency ntawm nas mitochondria hauv vitro thiab tej zaum yuav muaj cov nyhuv antioxidant.
Qee qhov kev tshawb fawb tau pom tias DSIP muaj feem cuam tshuam txog kev txhawb nqa qeeb-yoj pw tsaug zog (SWS) thiab inhibiting qhov muag nrawm nrawm (REM), thiab cov khoom siv hluavtaws DSIP kuj muaj zog rau kev pw tsaug zog.
Nws tuaj yeem cuam tshuam rau kev ua haujlwm ntawm tib neeg lub lens epithelial hlwb los ntawm MAPK txoj hauv kev, uas yog koom nrog hauv cell proliferation, sib txawv, txav, ciaj sia taus thiab apoptosis.

Muaj ntau txoj kev xa khoom rau koj xaiv

Peb lub zog:

Peb lub tuam txhab tau dhau los ntawm FDA thiab ISO19001 kev tswj hwm qhov system ntawv pov thawj. Thiab peb muaj kev koom tes nrog kev pom zoo nrog ntau lub Hoobkas thiab chaw kuaj hauv Suav teb, yog li peb tuaj yeem tsis tsuas yog muab cov neeg siv khoom xav tau.DSIPcov khoom, Kuj txhawb kev tshawb fawb, ntau lawm thiab muag ntawm lwm cov peptide hmoov.

Peb tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev thauj mus los, tab sis kuj txhawb ntau txoj kev them nyiaj, txawm tias koj siv nyiaj US, euros, Australian las, lossis cov nyiaj hauv zos los ntawm Singapore, Malaysia, Thaib, thiab lwm yam. Peb kuj tuaj yeem txhawb cov txiaj ntsig hauv zos hauv cov cheeb tsam thiab cov tebchaws no. Tsis tas li ntawd, peb kuj txhawb nqa cov npav hauv txhab nyiaj (credit cards, thiab lwm yam) rau kev them nyiaj.

Tsis lees paub: Cov ntaub ntawv luam tawm ntawm lub vev xaib no los ntawm Is Taws Nem, tsis tau txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm cov ntsiab lus. Thov ua tib zoo saib kom paub qhov txawv. Tsis tas li ntawd, cov khoom muab los ntawm peb lub tuam txhab tsuas yog siv rau kev tshawb fawb tshawb fawb. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.

Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais, thov hu rau peb los ntawmEmail :sales6@faithfulbio.com  . Peb pab neeg tau cog lus los ua kom tiav kev txaus siab ntawm cov neeg siv khoom.

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