ISRIB hmoovyog ib tug me me molecule compound, tshuaj muaj npeIntegrated Stress Response Inhibitor. Cov kev tshawb fawb tau pom tias nws yog ib qho kev xaiv PERK inhibitor nrog IC50 ntawm 5nM. Raws li cov ntaub ntawv tshawb fawb zaum kawg, ISRIB tau qhia txog kev kho mob muaj peev xwm hauv ntau hom kab mob, suav nrog kev txhim kho kev txawj ntse tom qab raug mob lub hlwb raug mob, thim rov qab spatial nco tsis taus hauv cov nas laus, txhim kho kev kawm thiab kev nco thiab hippocampal synaptic plasticity hauv Alzheimer tus kab mob qauv nas, txo cov mob pulmonary fibrosis, thiab txhawb nqa kev raug mob. Tam sim no, ISRIB tau txais kev pom zoo los ntawm FDA thiab tab tom ua kev sim tshuaj rau amyotrophic lateral sclerosis (ALS) thiab cov teeb meem dawb hyperintensities (VWM).
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Yam khoom |
Specification | Cov txiaj ntsig |
|
Qhov tshwm sim |
Dawb los yog tawm hmoov dawb | Dawb los yog tawm hmoov dawb |
|
kev zoo |
98% dhau los ntawm 40 mesh |
99.5% dhau lawm |
|
Cov khoom ua si |
Ntau dua lossis sib npaug li 99.8% |
99.98% |
|
Poob rau ziab |
Tsawg dua lossis sib npaug li 5.0% |
2.1% |
|
Poob ntawm ignition |
Tsawg dua lossis sib npaug li 5.0% |
2.3% |
|
Tag nrho arsenic (xws li As) |
Tsawg dua lossis sib npaug li 2 mg / kg |
2 mg/kg |
|
Lead (Pb) |
Tsawg dua lossis sib npaug li 2 mg / kg |
2 mg/kg |
|
Tag Nrho Phaj suav |
<1,000cfu/g |
650cfu/g |
|
E. Coli |
NMT 30 cfu/g |
< 30 cfu/g |
|
Salmonella |
Tsis pom muaj nyob hauv 10g |
Tsis muaj |
|
Poov thiab Pwm |
NMT 100 cfu/g |
< 100 cfu/g |
| Xaus: | Ua raws li kev lag luam specification. |
Yuav ua li cas yog lub mechanism ntawm kev txiav txim thiab daim ntawv thov kev taw qhia ntawm ISRIB hmoov?
ISRIB hmoovua hauj lwm los ntawm lub hom phiaj eIF2B complex. Thaum cov hlwb raug kev nyuaj siab, eIF2 yog phosphorylated, inhibiting cov haujlwm ntawm eIF2B thiab ua rau inhibition ntawm protein synthesis. ISRIB khi rau eIF2B, stabilizes nws active conformation, txhawb GDP thiab GTP pauv ntawm eIF2, yog li rov kho cov txheej txheem txhais lus thiab thim rov qab ua kom muaj kev sib koom ua ke ntawm kev ntxhov siab (ISR). Hauv daim ntawv thov qauv ntawm kev sim tshuaj, nws feem ntau qhia tau tias muaj peev xwm kho tau hauv cov qauv kab mob hauv qab no.
1. Cov kab mob neurological: tuaj yeem txhim kho kev txawj ntse tom qab raug mob lub hlwb, rov qab spatial nco tsis taus hauv cov nas laus, txhim kho kev kawm thiab kev nco, thiab hippocampal synaptic plasticity hauv Alzheimer's tus qauv nas.
2. Pulmonary fibrosis: Los ntawm inhibiting kev laus ntawm hom II pulmonary epithelial hlwb, nws alleviates silica induced pulmonary fibrosis nyob rau hauv nas.
3. Kev raug mob ntawm tus txha caj qaum: Txhawb nqa txha caj qaum raug mob rov qab los ntawm inhibiting neuronal apoptosis thiab tswj neuroinflammation.
4. Vascular kev paub tsis meej: txhim kho kev paub tsis meej los ntawm kev txhim kho CREB/BDNF txoj kev taw qhia.
Dab tsi yog qhov txawv ntawm ISRIB thiab lwm yam ISR modulators, thiab puas muaj kev phiv loj?
ISRIB inhibits ISR los ntawm kev ua kom eIF2B, thaum lwm yam ISR cov ntaub ntawv tswj hwm xws li salubrinal, guanabenz, thiab Sephin1 prolong ISR los ntawm inhibiting dephosphorylation ntawm eIF2 . Qhov zoo ntawmISRIB hmoovlus dag nyob rau hauv nws cov kev xaiv ntawm eIF2B thiab cov ntshav zoo-b hlwb barrier permeability.Tam sim no kev tshawb fawb qhia tias ISRIB tsis tau pom muaj toxicity nyob rau hauv cov tsiaj thwmsim.Nyob rau hauv tus nas qauv ntawm tus kab mob prion, kev kho ISRIB tej zaum yuav ua rau poob phaus, tejzaum nws tshwm sim los ntawm lub hom phiaj los. Zuag qhia tag nrho, ISRIB tau pom muaj kev nyab xeeb zoo hauv kev tshawb fawb ua ntej.
ISRIB qhov kev txhawb nqa - tso tawm microsphere formulation yog dab tsi?
Emulsification hnyav evaporation txoj kev yog feem ntau siv microsphere npaj txheej txheem, haum rau lipid soluble tshuaj. Cov kauj ruam tshwj xeeb suav nrog:
1. Roj theem npaj:DissolveISRIB hmoovthiab PLGA (polylactic acid hydroxyacetic acid copolymer) hauv cov organic hnyav los tsim cov roj theem kev daws teeb meem
2. Kev npaj dej theem:Dissolve emulsifier polyvinyl cawv (PVA) hauv dej los tsim cov tshuaj aqueous
3. Cov txheej txheem emulsification:ntxiv cov roj theem rau hauv cov dej theem nyob rau hauv siab -ceev shear tej yam kev mob los tsim cov dej hauv cov roj (O/W) emulsion droplets. Lub stirring ceev yog feem ntau 3500-10000 revolutions ib feeb
4. Cov kuab tshuaj evaporation:Txuas ntxiv qis- nrawm nrawm (300-600 rpm) ntawm chav tsev kub rau 6 teev kom maj mam evaporate cov organic hnyav thiab ua kom cov tee rau hauv microspheres
5. Post processing:Sau microspheres, ntxuav thiab khov kom qhuav kom tau txais cov khoom kawg
Peb lub tuam txhab pab pawg tshawb fawb tau ua qhov kev ua kom zoo dua qub ntawm cov txheej txheem los ntawm kev sib txuas SPG membrane emulsification technology nrog foaming pore forming agents. Raws li cov ntaub ntawv txheeb cais, cov txheej txheem tshiab tuaj yeem txuas ntxiv ib nrab ntawm - lub neej ntawm ISRIB hauv cheeb tsam lub paj hlwb los ntawm 2 teev hauv cov qauv tsim rau 72 teev, thiab nce nws cov bioavailability mus rau ntau dua 89%.
Muaj ntau txoj kev xa khoom rau koj xaiv
|
Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
|
3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
|
7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
|
|
15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Peb lub zog:
Peb lub tuam txhab tau dhau los ntawm FDA thiab ISO19001 kev tswj hwm qhov system ntawv pov thawj. Thiab peb muaj kev koom tes nrog kev cog lus nrog ntau lub Hoobkas thiab chaw kuaj hauv Suav teb, Peb lub tuam txhab tuaj yeem muabISRIB hmoovthiab lwm yam ntawm tus nqi zoo dua. Yog tias koj txaus siab, thov sau ib tsab ntawv.
Peb tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev thauj mus los, tab sis kuj txhawb ntau txoj kev them nyiaj, txawm tias koj siv nyiaj US, euros, Australian las, lossis cov nyiaj hauv zos los ntawm Singapore, Malaysia, Thaib, thiab lwm yam. Peb kuj tuaj yeem txhawb cov txiaj ntsig hauv zos hauv cov cheeb tsam thiab cov tebchaws no. Tsis tas li ntawd, peb kuj txhawb nqa cov npav hauv txhab nyiaj (credit cards, thiab lwm yam) rau kev them nyiaj.
FAQ:
Q1: Dab tsi yog nws qhov chaw cia khoom?
ISRIB hmoovtuaj yeem khaws cia rau 3 xyoos ntawm -20 ° C thiab 2 xyoos ntawm 4 ° C. Hauv cov kuab tshuaj, nws tuaj yeem khaws cia rau 6 lub hlis ntawm -80 ° C thiab 1 lub hlis ntawm -20 ° C. Solubility: DMSO 4mg / mL (8.86mM), insoluble lossis nyuaj rau yaj hauv dej thiab ethanol.
Q2: Yuav npaj cov tshuaj ISRIB li cas?
5mg ISRIB tuaj yeem npaj rau hauv 10mM tshuaj los ntawm kev ntxiv 1.11ml DMSO, lossis ntxiv 1ml DMSO txhua 4.51mg. SC4332-10mM tau npaj hauv DMSO.
Q3: Nws qhov chaw kho mob li cas?
ISRIB tau qhia txog kev siv dav dav hauv ntau yam kab mob paj hlwb, kab mob metabolic, thiab tiv thaiv- kev laus. Nws muab cov kev taw qhia tshiab rau kev kho kev ntxhov siab- cuam tshuam cov kab mob degenerative thiab cov kab mob metabolic los ntawm kev tswj hwm thiab kev sib koom ua ke cov lus teb kev ntxhov siab thiab mitochondrial muaj nuj nqi ntsig txog txoj hauv kev, kho endoplasmic reticulum stress thiab mitochondrial dysfunction.
Tsis lees paub: Cov ntaub ntawv luam tawm ntawm lub vev xaib no los ntawm Is Taws Nem, tsis tau txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm cov ntsiab lus. Thov ua tib zoo saib kom paub qhov txawv. Tsis tas li ntawd, cov khoom muab los ntawm peb lub tuam txhab tsuas yog siv rau kev tshawb fawb tshawb fawb. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.
Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais, thov hu rau peb los ntawmEmail :sales6@faithfulbio.com . Peb pab neeg tau cog lus los ua kom tiav kev txaus siab ntawm cov neeg siv khoom.
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