P21 Peptide

P21 peptideyog ib qho hluavtaws neuroprotective peptide muab los ntawm thaj chaw nquag tshaj plaws ntawm ciliary neurotrophic factor (CNTF) (amino acid residues 148-151). Nws yog ib qho tetrapeptide derivative rho tawm los ntawm CNTF siv epitope mapping technology thiab tshwj xeeb hloov (xws li, los ntawm kev ntxiv adamantylglycine) los txhim kho cov ntshav - hlwb thaiv kev nkag mus thiab stability. P21 peptide yog ib qho kev cog lus neuroprotective thiab kev txawj ntse- txhim kho peptide uas ua haujlwm los ntawm cov txheej txheem xws li kev txhim kho BDNF signaling, txhawb cov neurogenesis, thiab inhibiting neurodegenerative kab mob. Txawm hais tias tam sim no feem ntau txwv rau kev tshawb fawb daim ntawv thov, nws qhia tau hais tias muaj peev xwm zoo hauv thaj chaw ntawm neuroprotection, tiv thaiv kev laus, thiab kev txawj ntse.

P21 peptide exerts neuroprotective thiab kev txawj ntse- txhim kho cov teebmeem los ntawm ntau txoj hauv kev:
Txhim kho BDNF cov cim qhia: Ua kom muaj txiaj ntsig zoo ntawm lub hlwb - tau txais txiaj ntsig neurotrophic (BDNF), txhawb kev loj hlob ntawm neuronal thiab ciaj sia taus, thiab txhim kho synaptic plasticity;
Inhibition ntawm LIF txoj kev: Raws li ib qho inhibitor ntawm leukemia inhibitory factor (LIF) signaling, nws relieves inhibition ntawm paj hlwb regeneration.
Txhawb nqa neurogenesis: Txhawb nqa kev loj hlob thiab kev sib txawv ntawm cov kab mob neural qia hlwb hauv cov cheeb tsam hauv lub hlwb xws li hippocampus, thiab nce tus naj npawb ntawm cov neurons tshiab;
tau protein regulation: Txo cov kev ua GSK3, txo cov phosphorylation ntawm tau protein ntau, thiab tiv thaiv kev tsim ntawm neurofibrillary tangles (ib yam kab mob ntawm Alzheimer tus kab mob);
Antioxidant tiv thaiv: Txo oxidative kev nyuaj siab puas tsuaj thiab tiv thaiv neurons los ntawm -amyloid protein toxicity.