Name: Tuam Tshoj Afatinib API CAS 439081-18-2 Cov neeg muag khoom, chaw tsim khoom, Hoobkas - lag luam wholesale nqe - FAITHFUL
Brand: Ntseeg
SKU: 243814249

Hauj lwm lawm

Taw qhia rau Afatinib:

Afatinib hmoovyog ib yam khoom siv los kho qee yam mob qog noj ntshav, koom nrog hauv chav kawm ntawm cov khoom hu ua tyrosine kinase inhibitors (TKI). Nws tau pom zoo rau kev kho mob ntawm cov qog nqaij hlav tsis me me hauv lub ntsws thiab hauv zos qib siab lossis metastatic squamous cell non-me me ntawm lub ntsws cancer nrog qhov zoo ntawm EGFR hloov pauv. Cov tshuaj no tuaj yeem cuam tshuam kev loj hlob thiab kev sib kis ntawm cov qog nqaij hlav cancer los ntawm inhibiting qee cov protein ntawm cov qog hlwb.

Khoom npe	Afatinib
CAS	439081-18-2
Cov mis mos molecular	C24H25ClFN5O3
Molecular hnyav	485.94
Boiling point	676.9 ± 55. 0 degree (Predicted)
Qhov ntom	1.380
Kev cia khoom	Khaws ntawm -20 degree
Solubility	Ntau dua lossis sib npaug rau 24.3 mg / ml hauv DMSO; Insoluble hauv dej; Ntau tshaj los yog sib npaug rau 42.1 mg / mL, ethanol tov
Qhov tshwm sim	Dawb mus rau dawb hmoov
Acidity coefficient (pKa)	12.

Dab tsi yogAfatinib?

Afatinib yog tshuaj tiv thaiv qog nqaij hlav ntawm tyrosine kinase inhibitor. Nws muaj peev xwm irreversibly inhibit lub autophosphorylation ntawm tyrosine kinase.

(E / Z)-Afatinib yog cov sib xyaw ntawm (E)-Afatinib thiab (Z)-Afatinib. Afatinib (HY-10261) yog ib qho EGFR inhibitor uas tsis tuaj yeem thim rov qab, uas thaiv kev ua haujlwm ntawm EGFR, HER2, HER4 thiab EGFRvIII los ntawm irreversibly khi rau nws qhov chaw ATP khi. Afatinib ua ke nrog Temozolomide (HY-17364) tuaj yeem ua rau lub hom phiaj EGFRvIII-cMet teeb liab hloov pauv hauv glioblastoma hlwb.

Afatinib hmoovyog ib qho tshuaj tiv thaiv kab mob qog noj ntshav tshiab, uas yog, tiam tshiab ntawm lub hom phiaj tshuaj, uas yog thawj cov tshuaj tiv thaiv kab mob qog noj ntshav hauv ntiaj teb uas irreversibly khi rau tsev neeg ErbB (xws li plaub yam mob qog noj ntshav sib txawv ntawm cov kab mob qog noj ntshav, xws li raws li EGFR, HER2, ERB3 thiab ERB4), yog li thaiv cov cim qhia uas ua rau kev loj hlob ntawm cov qog nqaij hlav cancer zoo dua thiab cuam tshuam, thiab txo qis lossis ncua kev loj hlob ntawm cov qog nqaij hlav cancer. Afatinib tau raug pom zoo ua thawj kab tshuaj kho mob hauv Tebchaws Meskas, Tebchaws Europe thiab Taiwan, thiab nws yog hom tshuaj kho mob ib hnub ib zaug rau NSCLC nrog EGFR hloov pauv qog noj ntshav.

Khoom Specification

Yam khoom	Specification	Cov txiaj ntsig
Qhov tshwm sim	Hmoov	Ua raws
Xim	Dawb hmoov hmoov	Ua raws
Particle Loj	100% dhau 80 mesh	Ua raws
Oder	Yam ntxwv	Ua raws
Saj	Yam ntxwv	Ua raws
Poob rau ziab	Tsawg dua lossis sib npaug rau 5.0%	2.20%
Residue ntawm Ignition	Tsawg dua lossis sib npaug rau 0.1%	0.05%
Residual acetone	Tsawg dua lossis sib npaug rau 0.1%	Ua raws
Residual Ethanol	Tsawg dua los yog sib npaug rau 0.5%	Ua raws
Heave Mentals	Tsawg dua lossis sib npaug li 10ppm	Ua raws
Na	Tsawg dua lossis sib npaug rau 0.1%	<0.1%
Pb	Tsawg dua lossis sib npaug li 3 ppm	Ua raws
Total Phaj	<1000CFU/g	Ua raws
Poov & Pwm	<100 CFU /g	Ua raws
E. Coli	Tsis zoo	Ua raws
Salmonella	Tsis zoo	Ua raws
Xaus: Ua raws li USP Standard

Cov txheej txheem tshawb fawb ntawm Afatinib yog dab tsi?

1. Afatinib hmoovyog ib qho tshuaj irreversible rau NSCLCm + cov neeg mob nrog advanced EGFR hloov. Kev tsom xam ntawm biomarkers qhia tau hais tias CISH yuav yog ib qho kev cog lus ntawm cov tshuaj tiv thaiv ntawm afatinib, thiab kev kho neoadjuvant ntawm afatinib kuj yuav ua rau cov kev hloov pauv ntawm cov qog microenvironment.
2. Cov qog nqaij hlav qog nqaij hlav tsis me me yog ib hom mob ntsws cancer ntau tshaj plaws, thiab ntau tus neeg mob muaj EGFR hloov pauv. Lub sijhawm no, EGFR-TKI tau pom zoo ua thawj qhov kev xaiv rau kev kho mob.
3. Cov phiaj xwm kho mob yog ib txoj hauv kev tseem ceeb rau cov neeg mob uas muaj tus mob metastatic ntsws adenocarcinoma. Raws li tiam thib ob EGFR-TKI, alfatinib qhia tau hais tias muaj txiaj ntsig zoo dua, tshwj xeeb tshaj yog rau cov neeg mob alveolar cell carcinoma. Cov phiaj xwm kev kho mob yog qhov tseem ceeb hauv kev kho mob ntsws cancer, thiab cov txiaj ntsig zoo kawg rau qee cov neeg rhiab heev.

Afatinib mechanism yog dab tsi?

Afatinib hmoovyog ib qho irreversible ErbB tsev neeg blocker, uas tuaj yeem cuam tshuam cov ntaub ntawv xa mus thiab thaiv cov channel tseem ceeb ntsig txog kev loj hlob thiab kev faib tawm ntawm cov qog nqaij hlav cancer. Vim tias nws tuaj yeem tshwm sim los ntawm ntau homodimers thiab heterodimers los ntawm ErbB tsev neeg cov ntaub ntawv kis tau tus mob, ib txhij inhibiting ntau ErbB tsev neeg (xws li EGFR, HER2, ErbB3 thiab ErbB4) tuaj yeem cuam tshuam cov ntaub ntawv xa mus hauv qab.

Hauv cov qog nqaij hlav cancer, kev ua haujlwm ntawm tsev neeg ErbB feem ntau tsis muaj qhov sib npaug. Thaum cov xwm txheej tswj cov txheej txheem ntawm kev loj hlob ntawm tes tau nthuav tawm ntau dhau los yog txawv txav, nws tuaj yeem ua rau ntau yam qog nqaij hlav. Overexpression ntawm receptors yuav ua rau lub intracellular cov ntaub ntawv kis tau tus mob tshaj li ib txwm theem, ua rau uncontrolled kev loj hlob, tsiv teb tsaws thiab metastasis ntawm qog hlwb thiab inhibit lawv apoptosis.

Qhov twg yog siv afatinib?

1. Ntev mus ntev-dawb ciaj sia taus (PFS): Hauv ntau qhov kev sim tshuaj, afatinib tau pom tias muaj kev vam meej tsis muaj sia nyob ntev dua piv nrog cov tshuaj ALK ib txwm muaj xws li Crizotinib. Qhov no txhais tau hais tias cov qog loj zuj zus mus ntev dua tom qab tus neeg mob tau kho nrog afatinib.

2. Txhim kho kev ciaj sia tag nrho (OS): Cov neeg mob kho nrog afatinib feem ntau qhia tias muaj sia nyob ntev dua, tshwj xeeb tshaj yog cov neeg uas hloov mus rau afatinib tom qab tus kab mob loj tuaj.

3. Kev ua siab ntev ntev: Piv nrog rau lwm cov ALK inhibitors, afatinib feem ntau muaj kev ua siab ntev zoo dua thiab txo qee qhov kev phiv tshwm sim, xws li plab hnyuv thiab qhov muag tsis pom kev.

4. Kev tswj lub paj hlwb hauv nruab nrab: Afatinib tuaj yeem nkag mus rau hauv cov hlab ntsha-hlwb barrier, yog li nws kuj tseem yuav muaj kev tswj xyuas zoo rau cov neeg mob uas muaj cov hlab ntsha hauv nruab nrab metastasis.

5. Haum rau cov neeg mob ntawm ntau theem: Afatinib tau ua pov thawj tias muaj txiaj ntsig zoo rau cov neeg mob ALK-zoo NSCLC uas tsis tau kho thiab cov uas tau txais lwm yam kev kho mob tab sis tau rov ua dua lossis metastasized.

Feem ntau hais lus, afatinib yog ib qho kev kho mob zoo, uas tuaj yeem txhim kho txoj sia nyob thiab lub neej zoo ntawm cov neeg mob ALK zoo uas tsis yog mob qog noj ntshav me me.

Yuav ua li cas thiab qhov twg yuav Afatinibhmoovlag luam wholesale?

Koj tuaj yeem tso siab rau peb qhov kev txiav txim, vim tias peb muaj cov ntaub ntawv zoo ntawm kev muag tshuaj raws cai.

Peb ua qhov kev kuaj xyuas ywj pheej ntawm txhua yam khoom thiab tom qab ntawd muag rau peb cov neeg siv khoom hwm.

Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.

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Muaj ntau txoj kev xa khoom rau koj xaiv

Tsheb thauj mus los	Shipping txoj kev	Cargo hnyav xav tau	Qhov zoo
3-7 hnub	DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, UPS, USPS, FedEx, TNT, EMS	Haum rau qis dua 50kg. International qhov rooj rau qhov rooj nthuav qhia	Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, thiab cov neeg siv khoom hauv Tebchaws Europe thiab Asmeskas tuaj yeem ua tau txaus siab xa khoom ncaj qha los ntawm ob qhov chaw no.
7-15 hnub	Los ntawm Cua	Haum rau ntau tshaj 50kg. ceev thiab pheej yig dua rau kev txiav txim loj
15-60 hnub	Los ntawm Hiav Txwv	Haum rau ntau tshaj 500kg. Kev xa khoom pheej yig tshaj plaws

Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.

Tsis lees paub: Cov ntawv luam tawm ntawm lub xaib no yog siv los txhawb kev sib pauv kev kawm thiab kev kawm, thiab tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov lim kom zoo. Yog tias koj ntseeg tias tsab xov xwm no ua txhaum, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.

Nco tseg: Cov tshuaj no yuav tsum tau siv rau kev tshawb fawb nkaus xwb. Cov lus thov no tsis tau raug soj ntsuam los ntawm Food and Drug Administration. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv lawv. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho lossis tiv thaiv kab mob.

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