Bicalutamide 99% Dawb hmoov CAS 90357-06-5

Bicalutamide 99% hmoov dawbyog soluble hauv dimethylformamide; Dissolve hauv tetrahydrofuran; me ntsis soluble hauv ethyl acetate thiab methanol; Insoluble hauv dej. Crystallized los ntawm 1: 1 (ntim piv) ethyl acetate thiab roj av ether, melting point 191 ~ 193 degree, boiling point 650.3 ± 55.0 degree (Predicted), ceev 1.52 0.1 g /cm3 (kwv yees).

Bicalutamide yog cov tshuaj uas tsis yog-steroidal antiandrogen, uas yog siv ua ke nrog luteinizing hormone-tso hormone (LHRH) analog lossis phais orchiectomy rau kev kho mob qog noj ntshav siab. Nws tsis muaj kev cuam tshuam rau lwm cov tshuaj hormones, thiab nws khi nrog cov androgen receptors, yog li nws tsis muaj kev qhia cov noob zoo, yog li inhibiting stimulation ntawm androgen thiab ua rau atrophy ntawm prostate qog.

Bicalutamide yog dab tsi?

Bicalutamide 99% hmoov dawbyog ib qho uas tsis yog-steroidal androgen antagonist, uas sib tw nrog androgen rau cov androgen receptors, blocks lub uptake ntawm androgen los ntawm cov hlwb, thiab inhibits kev sib xyaw ntawm androgen nrog lub hom phiaj. Tom qab ua ke nrog cov androgen receptor, nws tsim cov receptor complex, nkag mus rau hauv lub nucleus, thiab sib txuas nrog cov protein ntau, yog li inhibiting kev loj hlob ntawm cov qog hlwb. Nws tuaj yeem siv los ua thawj kab tshuaj rau kev kho mob palliative ntawm kev mob qog noj ntshav prostate.

Bicalutamide yog ib qho androgen-resistant non-corticosteroid uas tuaj yeem siv los ua cov tshuaj ntxiv hauv kev kho mob qog noj ntshav prostate, thiab nws tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev kho mob qog noj ntshav prostate ntxov.

Nws cov qauv zoo ib yam li cov flutamide thiab nilutamide. Nws tag nrho inhibits qhov kev txiav txim ntawm endogenous androgens nyob rau hauv cov ntaub so ntswg rhiab heev, nrog rau lub testis, prostate, lub mis, daim tawv nqaij, thiab hypothalamus, los ntawm khi rau androgen receptors nyob rau hauv lub hlwb. Bicalutamide tau pom zoo rau npe hauv Tebchaws Meskas hauv xyoo 1995.

Bicalutamide ua haujlwm li cas?

Bicalutamide 99% hmoov dawbyog cov tshuaj uas tsis yog-steroidal antiandrogen, uas tsis muaj kev cuam tshuam rau lwm cov tshuaj hormones. Nws khi rau cov androgen receptors, uas ua rau tsis muaj txiaj ntsig gene qhia, yog li inhibiting androgen stimulation thiab ua rau atrophy ntawm prostate qog. Nws yog ib haiv neeg, thiab nws cov nyhuv antiandrogen tsuas yog tshwm sim ntawm (R) tus qauv enantiomer.

Bicalutamide yog ib qho tshuaj tiv thaiv androgen zoo thiab sib xyaw ua haujlwm oxidase inducer hauv cov tsiaj. Cov kev hloov ntawm cov tsiaj lub hom phiaj ntawm lub cev muaj feem xyuam rau cov teebmeem no, nrog rau cov qog induction. Hauv tib neeg lub cev, enzyme induction tsis tau pom. Cov txiaj ntsig ntawm kev sim tshuaj preclinical yog suav tias tsis cuam tshuam rau kev kho mob ntawm cov neeg mob qog nqaij hlav cancer prostate.

Dab tsi yog thaj chaw thov ntawm bicalutamide?

1. Nws yog siv ua ke nrog luteinizing hormone-releasing hormone (LHRH) analog lossis phais orchiectomy rau kev kho mob qog noj ntshav siab.

2. Nws yog siv rau kev mob qog noj ntshav hauv zos uas tsis muaj cov kab mob nyob deb uas tsis tsim nyog lossis tsis kam mus phais castration lossis lwm yam kev kho mob.

3. V1 siv tshuaj antiandrogen. Nws yog ib qho tshuaj kho mob qog noj ntshav prostate, thiab yog siv los kho mob qog noj ntshav prostate.

4. Nws yog ib qho antiandrogen.

Dab tsi yuav tsum tau them nyiaj rau kev siv bicalutamide?

Bicalutamide yog dav metabolized nyob rau hauv daim siab. Cov ntaub ntawv qhia tau hais tias kev tshem tawm cov tshuaj yuav ua rau qeeb hauv cov neeg mob uas mob siab rau lub siab, uas tuaj yeem ua rau muaj ntau ntxiv. Yog li ntawd, nws yuav tsum tau siv nrog ceev faj rau cov neeg mob uas mob siab thiab mob siab heev.

Lub siab hloov pauv tuaj yeem tshwm sim, thiab kev kuaj lub siab tsis tu ncua yuav tsum tau txiav txim siab. Cov kev hloov loj feem ntau tshwm sim hauv thawj 6 lub hlis ntawm kev kho mob nrog cov khoom no.

Kev hloov pauv ntawm daim siab ua haujlwm hnyav tsis tshua muaj nyob rau hauv kev kho mob bicalutamide. Yog tias muaj kev hloov pauv loj, kev kho mob yuav tsum raug tso tseg.

Nws qhia tau hais tias nws inhibits cov haujlwm ntawm cytochrome P450 (CYP3A4), yog li nws yuav tsum tau siv nrog ceev faj thaum ua ke nrog cov tshuaj feem ntau metabolized los ntawm CYP3A4.

Cev xeeb tub thiab lactation: txwv tsis pub rau cov poj niam, tshwj xeeb tshaj yog rau cov poj niam cev xeeb tub lossis leej niam pub niam mis.

Kev cuam tshuam ntawm kev muaj peev xwm tsav tsheb thiab ua haujlwm tshuab: Nws yuav tsis cuam tshuam rau tus neeg mob lub peev xwm tsav tsheb thiab ua haujlwm tshuab.

Yuav xaiv cov khoom siv li cas

Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.

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Muaj ntau txoj kev xa khoom rau koj xaiv

Tsis lees paub: Cov ntawv luam tawm ntawm lub vev xaib no yog siv los txhawb kev sib pauv kev kawm thiab kev kawm, thiab tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov lim kom zoo. Yog tias koj ntseeg tias tsab xov xwm no ua txhaum, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.

Nco tseg: Cov tshuaj no yuav tsum tau siv rau kev tshawb fawb nkaus xwb. Cov lus thov no tsis tau raug soj ntsuam los ntawm Food and Drug Administration. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv lawv. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho lossis tiv thaiv kab mob.

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