Pirfenidone hmoov CAS 53179-13-8

Pirfenidone hmoovyog ib yam tshuaj, hmoov dawb, molecular mis: C12H11NO, molecular hnyav: 185.222, ceev: 1.137 g/cm3, melting point: 96-97ºC, boiling point: 329.1ºC Nws yog ib tug tshiab anti-fibrosis me me molecule compound. , belongs rau cov tshuaj pyridine. Soluble nyob rau hauv cawv thiab chloroform, thiab insoluble nyob rau hauv dej, molecules hla lub cell nto tsis xav tau receptors. Nws tau txais lub npe ntawm cov tshuaj menyuam ntsuag los ntawm FDA ntawm Tebchaws Meskas thiab EMA ntawm European Union. Lub ntiaj teb thawj zaug thiab tib cov tshuaj kho mob kom tau txais qhov qhia txog idiopathic pulmonary fibrosis (IPF).

Pirfenidone yog dab tsi?

Tus kab mob ntsws interstitial yog ib pab pawg ntawm heterogeneous non-tumor thiab non-infectious ntsws kab mob nrog o thiab interstitial fibrosis ntawm alveolar units raws li cov kev hloov pauv pathological. Nyob rau hauv lub mob hnyav, nws yog feem ntau raug mob los yog o, thiab nyob rau hauv lub sij hawm ntev, nws feem ntau yog fibrosis. Nyob rau hauv xyoo tas los no, nrog kev nce qib ntawm kev kho mob mus tas li, kev tshawb fawb ntawm cov kab mob ntsws interstitial tau dhau los ua qhov tob thiab tob, thiab kev faib cov kab mob tau dhau los ua kom ntxaws. Ntau hom kab mob ntsws interstitial muaj ntau yam kev kuaj mob thiab kev kho mob.

Pirfenidone hmoovtuaj yeem tiv thaiv thiab thim rov qab fibrosis thiab caws pliav; Nws tau teev tseg los ntawm Shionogi hauv 2008 thiab tau pom zoo los ntawm US Food and Drug Administration. Nws yog thawj cov tshuaj uas muaj qee yam kev kho mob ntawm idiopathic pulmonary fibrosis (IPF) los ntawm kev rov ua dua, randomized, placebo-tswj theem III kev sim tshuaj.

Qhov twg yog pirfenidon haum rau?

1. Idiopathic pulmonary fibrosis

Idio-pathic pulmonary fibrosis (IPF) yog ib qho mob inflammatory interstitial ntsws kab mob uas tsis paub ua, tsis zoo, thiab kev tuag siab. Pirfenidone yog ib qho tshuaj tiv thaiv kab mob thiab tiv thaiv fibrosis, uas tuaj yeem siv los kho IPF.

2. Lub siab fibrosis

3. Kab mob raum fibrosis

4. Ntau yam sclerosis

Ntau tus kab mob sclerosis (MS) yog ib qho kab mob inflammatory thiab demyelinating cuam tshuam nrog lub hauv nruab nrab lub paj hlwb thiab kev tiv thaiv kab mob. Cov yam ntxwv ntawm lub cev tiv thaiv kab mob yog kev ua kom cov stellate hlwb, glial hlwb, endothelial hlwb, thiab nce lymphocytes, thaum Pirfenidone muaj cov yam ntxwv ntawm inhibiting cell activation.

5. Myocardial fibrosis

Cov kab mob plawv, xws li kub siab, cardiomyopathy, thiab atrial fibrillation, txhua tus tuaj yeem ua rau myocardial fibrosis, thiab tom qab ntawd ua rau mob hnyav lossis tsim tus kab mob.

6. Cov kab mob qog: neurofibroma, uterine leiomyoma, malignant glioma.

7. Kev tiv thaiv ntawm fibrosis tom qab hloov lub cev

8. Mob caj dab caj dab

Pirfenidone ua haujlwm li cas?

Pirfenidone hmoovyog ib qho zoo cytokine inhibitor, uas tuaj yeem cuam tshuam kev ua haujlwm lom neeg ntawm fibroblasts thiab txo cov cell proliferation thiab matrix collagen synthesis los ntawm kev tswj lossis inhibiting qee yam. Nyob rau tib lub sijhawm, nws tuaj yeem cuam tshuam qhov tso tawm ntawm cov kab mob sib kis, txo cov lipid peroxidation, thiab lwm yam, thiab siv nws cov tshuaj tiv thaiv kab mob thiab antioxidant.

1. inhibit collagen synthesis

Pirfenidone tuaj yeem txo qhov kev qhia ntawm bFGF, TGF-, CTGF, thiab TIMP-1 hauv fibroblasts ntawm lub ntsws, ob lub raum, thiab lwm yam kabmob, thiab nws muaj feem cuam tshuam nrog collagen synthesis thiab matrix txo. Kev tsim khoom ntawm hom ⅰ thiab hom ⅲ collagen fibers kuj zoo sib xws rau cov synthesis ntawm matrix collagen. Nws tuaj yeem tsis tsuas yog txo cov kev qhia ntawm TGF- tab sis kuj txo qis kev tsim ntawm -ⅰ collagen.

2. Anti-inflammatory nyhuv

Nws tuaj yeem inhibit inflammatory mediators los ntawm exerting lawv anti-inflammatory teebmeem rau ntau qib.

3. Antioxidant nyhuv

Nws exerts nws cov nyhuv antioxidant los ntawm kev tshem tawm cov dawb radicals, inhibiting lipid peroxidation, thiab txo oxidative kev nyuaj siab.

Cov kev phiv ntawm pirfenidon yog dab tsi?

Pirfenidone yog ib qho tshuaj rau pulmonary fibrosis, uas yog tsim rau me me mus rau nruab nrab idiopathic pulmonary fibrosis. Qee qhov kev mob tshwm sim kuj tshwm sim thaum siv, thiab cov neeg mob yuav muaj cov kab mob hauv plab, xws li xeev siab, plab zom mov, ntuav, anorexia, thiab lwm yam. Cov neeg mob kuj muaj kev tsis haum rau lub teeb, thiab daim tawv nqaij yuav tshwm sim tom qab siv. Yog li, nws raug pom zoo tias cov neeg mob yuav tsum siv tshuaj pleev thaiv hnub kom tsis txhob raug ultraviolet rays thiab tiv thaiv cov tawv nqaij ua xua thaum siv cov tshuaj no.

Tsis tas li ntawd, daim siab ua haujlwm yuav raug puas tsuaj, transaminase tuaj yeem nce ntxiv, thiab jaundice kuj tuaj yeem tshwm sim hauv cov neeg mob. Yog li ntawd, cov neeg mob raug qhia kom saib xyuas lub siab ua haujlwm tsis tu ncua.

Yuav xaiv cov khoom siv li cas

Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.

Koj tuaj yeem tiv tauj kuv ntawm WhatsApp:+86 13137770562

Muaj ntau hom kev xa khoom rau koj xaiv

Tsis lees paub: Cov ntawv luam tawm ntawm lub vev xaib no yog siv los txhawb kev sib pauv kev kawm thiab kev kawm, thiab tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov lim kom zoo. Yog tias koj ntseeg tias tsab xov xwm no ua txhaum, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.

Nco tseg: Cov tshuaj no yuav tsum tau siv rau kev tshawb fawb nkaus xwb. Cov lus thov no tsis tau raug soj ntsuam los ntawm Food and Drug Administration. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv lawv. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho lossis tiv thaiv kab mob.

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