Canagliflozin hmoov CAS 842133-18-0
Khoom npe: Canagliflozin; Canaglifozion; Cagliflozin; CS-183; Invokana
CAS Nr.: 842133-18-0
Cov mis mos molecular: C24H25FO5S
Purity & Qib: 99% HPLC; Qib tshuaj
MOQ & Pob: 10g; Pob raws li xav tau
Shipping: Kev nyab xeeb thiab xa khoom sai
Khw & Txee lub neej: Txias & qhuav qhov chaw; 24 hli
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Daim ntawv pov thawj: COA; HPLC; MSDS; TDS, thiab lwm yam.
Hauj lwm lawm
Canagliflozin yog dab tsi?
Canagliflozin yog ib qho kev xaiv SGLT2 inhibitor, uas ua rau CHO hlwb qhia mSGLT2, rSGLT2 thiab hSGLT2 nrog IC50 ntawm 2 nM, 3.7 nM thiab 4.4 nM, raws li. Canagliflozin yog tshuaj lom neeg, thiabCanagliflozin hmoovyog cov hmoov dawb dawb uas muaj kev ruaj ntseg tsis zoo, uas yuav tsum tau muab cia rau hauv qhov chaw qhuav, tsaus thiab txias. cov
| Khoom npe | Canagliflozin |
| CAS | 842133-18-0 |
| Cov mis mos molecular | C24H25FO5S |
| Molecular hnyav | 444.52 |
| EINECS Number | 695-192-1 |
| Kev cia khoom | -20 degree |
| Melting point | 68 - 72 degree |
| Solubility | Dissolved hauv DMSO (40 mg / ml) |
| Qhov tshwm sim | Dawb hmoov |
| Boiling point | 642.9 ± 55. 0 degree (Predicted) |
| Qhov ntom | 1.364 |
Canagliflozin ua haujlwm li cas?
Khoom Specification
| Yam khoom | Specification | Cov txiaj ntsig |
| Yam ntxwv | Dawb los yog dawb crystalline hmoov | Ua raws |
| Kev txheeb xyuas | Los ntawm IR | Ua raws |
| Los ntawm HPLC | Ua raws | |
| Melting Point | 95ºC~105ºC | 101ºC~102ºC |
| Cov ntsiab lus dej | 2.0%~3.0% | 2.50% |
| Hnyav Hlau | Tsawg dua lossis sib npaug li 20ppm | Ua raws |
| Residue ntawm Ignition | Tsawg dua lossis sib npaug rau 0.10% | 0.06% |
| Isomer | Tsawg dua lossis sib npaug rau 0.15% | ND |
| Yam khoom muaj feem | Ib qho impurity: Tsawg dua lossis sib npaug rau 0.20% | 0.06% |
| Tag nrho cov impurities: Tsawg dua lossis sib npaug rau 0.50% | 0.16% | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.50% | 99.84% |
| Daim ntawv pov thawj | Hauv tsev Standard | |
Kev siv ntawm Canagliflozin yog dab tsi?
Ua ntej, cov nyhuv hypoglycemic
1. Inhibition ntawm sodium-glucose cotransporter (SGLT): Canagliflozin tuaj yeem tsis tsuas yog txhim kho cov tshuaj insulin los ntawm inhibiting lub raum SGLT2, tab sis kuj yog ib feem txo qis ntshav qabzib nce ntxiv los ntawm inhibiting SGLT1 kom ncua kev nqus cov piam thaj hauv cov hnyuv, uas muaj ob qho kev cuam tshuam ntawm -glucosidase inhibitor thiab lub raum mechanism.
2. Txhim kho islet muaj nuj nqi:Canagliflozin hmoovtuaj yeem nce qib adiponectin hauv cov ntshav, txo cov visceral adipose cov ntaub so ntswg thiab cov rog ectopic, yog li txo cov tshuaj insulin.
3. Kev loj hlob ntawm -cells: Qhov ceev ntawm parasympathetic paj hlwb (PN) thiab cov hlab ntsha fiber ntau nyob rau hauv epidermis tau nce tom qab siv cov Canagliflozin, uas txhim kho qhov poob ntawm unmyelinated fibrils nyob rau hauv thaum ntxov theem ntawm DPN, yog li nce V.
Thib ob, poob phaus thiab lipid-txo cov nyhuv:
Kev poob qis ntawm lub cev thaum ntxov yog tshwm sim los ntawm cov kua dej tawm los ntawm kev txhawb nqa ntawm natrium ntawm Canagliflozin, thiab kev poob qis ntawm lub cev yog tshwm sim los ntawm kev txo qis ntawm calories thiab ua rau txo qis ntawm cov rog.
Thib peb, cov nyhuv antihypertensive
Nyob rau hauv cov xwm txheej ntawm hyperglycemia (HG), cov piam thaj ntau dhau nkag mus rau hauv lub raum tubular hlwb (PTC) los ntawm SGLT2, uas txhawb kev tsim cov raum angiotensinogen (AGT), ua kom lub raum renin-angiotensin system (RAS), nce qib ntawm lub raum angiotensin II. , thiab ua rau sodium retention thiab arterial siab. Canagliflozin tuaj yeem cuam tshuam rau lub raum los ntawm kev thaiv SGLT2 kom txo qis kev tsim tawm ntawm ROS hauv PTC thiab nce qhov kev qhia ntawm lub raum AGT.
Plaub, txo uric acid
Canagliflozin tuaj yeem txo qis qib uric acid hauv cov ntshav thiab txo qhov kev pheej hmoo ntawm thawj ntu thiab rov tshwm sim ntawm gout tsis zoo tshwm sim los ntawm ib nrab.
V. Kev tiv thaiv kab mob plawv
Cov kev tshawb fawb tau pom tias Canagliflozin tuaj yeem txo qhov kev pheej hmoo ntawm cov kab mob plawv loj (kab plawv tuag, tsis tuag myocardial infarction lossis tsis tuag taus). Qee qhov kev tshawb fawb tau qhia tias Canagliflozin muaj kev tiv thaiv thawj zaug thiab theem nrab ntawm cov kab mob plawv.
HTML5 atlas of Canagliflozin
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Puas yog canagliflozin tib yam li metformin?
Muaj qhov sib txawv ntawm Canagliflozin thiab metformin hauv cov txheej txheem hypoglycemic. Canagliflozin belongs rau sodium glucose cotransporter 2 inhibitor. Feem ntau los ntawm kev txo qis lub raum cov piam thaj hauv lub raum, txo cov ntshav qabzib rov qab los ntawm lub raum, thiab ua kom cov kua nplaum tawm ntawm cov zis, yog li ua lub luag haujlwm hauv kev txo cov ntshav qab zib. Metformin feem ntau txo cov ntshav qab zib los ntawm inhibiting qhov chaw ntawm cov piam thaj thiab nce cov piam thaj. Tsis tas li ntawd, metformin tuaj yeem txhim kho cov tshuaj insulin. Ob cov tshuaj uas tau hais los saum toj no yog cov tshuaj hypoglycemic, yog li nws raug nquahu kom siv lawv raws li kev qhia ntawm tus kws kho mob, thiab tsis txhob siv los ntawm koj tus kheej.
Cov txiaj ntsig ntawm canagliflozin yog dab tsi?
Cov kev mob tshwm sim ntawm kev siv ntev ntev ntawm Canagliflozin muaj xws li kev tsis haum tshuaj, kab mob urinary, kab mob ntawm qhov chaw mos, hypoglycemia, teeb meem rau lub raum, thiab lwm yam. Kev tshuaj xyuas tshwj xeeb yog raws li hauv qab no:
1. kev tsis haum tshuaj
Kev siv ntev ntev ntawm Canagliflozin tuaj yeem ua rau hlwv thiab tev ntawm daim tawv nqaij, thiab txawm tias dysphagia, uas yog ib qho kev tsis haum tshuaj.
2. Cov kab mob tso zis
Thaum siv Canagliflozin, tej zaum yuav muaj teeb meem ntawm cov kab mob urinary, xws li hematuria thiab mob thaum tso zis.
3. Lub sij hawm kis kab mob
Thaum siv, qhov chaw mos khaus thiab qhov txawv txav ntawm qhov tso tawm tuaj yeem tshwm sim, thiab cov txiv neej yuav muaj qhov mob noov thiab o, uas yog ib qho kev mob tshwm sim ntawm qhov chaw mos.
4. Hypoglycemia
Canagliflozin yog cov tshuaj hypoglycemic. Yog tias nws tsis siv kom raug, nws tuaj yeem ua rau hypoglycemia hauv cov neeg mob, feem ntau tshwm sim los ntawm kiv taub hau thiab lub plawv dhia ceev.
5. teeb meem raum
Tej zaum kuj yuav muaj kab mob raum thaum siv, xws li tsis muaj peev xwm tso zis thiab hloov cov zis tso zis.
Yuav ua li cas thiab qhov twg yuav Canagliflozin Powder wholesale?
Koj tuaj yeem tso siab rau peb qhov kev txiav txim vim tias peb muaj cov ntaub ntawv zoo ntawm kev muag tshuaj qhia kev cai lij choj.
Peb ua qhov kev kuaj xyuas ywj pheej ntawm txhua yam khoom thiab tom qab ntawd muag rau peb cov neeg siv khoom hwm.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Muaj ntau txoj kev xa khoom rau koj xaiv
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Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
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3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
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7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:allen@faithfulbio.comTam sim no.
Tsis lees paub: Cov ntawv luam tawm ntawm lub xaib no yog siv los txhawb kev sib pauv kev kawm thiab kev kawm, thiab tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov lim kom zoo. Yog tias koj ntseeg tias tsab xov xwm no ua txhaum, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab cov kev pabcuam hauv lub vev xaib no.
Nco tseg: Cov tshuaj no yuav tsum tau siv rau kev tshawb fawb nkaus xwb. Cov lus thov no tsis tau raug soj ntsuam los ntawm Food and Drug Administration. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv lawv. Cov khoom no tsis yog tsim los kuaj xyuas, kho, kho, lossis tiv thaiv txhua yam kab mob.
Cim npe nrov: canagliflozin hmoov cas 842133-18-0, Suav teb, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua nyob rau hauv Tuam Tshoj
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