Caspofungin hmoov CAS 162808-62-0

Caspofungin yog dab tsi?

Caspofungin hmoovyog thawj echinocandin khoom pom zoo rau kev kho mob ntawm invasive fungal kab mob. Caspofungin yog ib qho semi-synthetic lipopeptide (echinocandin) compound tau los ntawm cov khoom fermentation ntawm Glarea Lozoyensis. Caspofungin acetate inhibits cov synthesis ntawm (1,3)-D-glucan, ib qho tseem ceeb ntawm cov phab ntsa ntawm tes ntawm ntau filamentous fungi thiab poov xab. (1,3)-D-glucan tsis muaj nyob rau hauv cov tsiaj txhu. Cov kev tshawb fawb hauv vitro pharmacological tau pom tias Aids-058650 muaj cov tshuaj tua kab mob tiv thaiv ntau yam kab mob Aspergillus thiab Candida. Hauv vitro thiab hauv vivo kev sim tshuaj tshuaj tau tshawb pom tias Caspofungin muaj cov tshuaj tua kab mob zoo tshaj plaws tiv thaiv cov kab mob kis tau zoo xws li Candida thiab Aspergillus. Nws cov txheej txheem ntawm kev ua haujlwm yog inhibit biosynthesis ntawm 1, 3- -glucan hauv cov phab ntsa ntawm cov kab mob fungal thiab cuam tshuam cov qauv ntawm cov kab mob fungal; Cov ntawv thov kev kho mob kuj tau lees paub tias cov tshuaj no muaj cov txiaj ntsig zoo rau ntau hom candidiasis thiab aspergillosis.

tiv tauj peb ntawm Email :sales6@faithfulbio.com

Caspofungin hloov cov kab mob fungal cell li cas?

Qhov tshwm sim ntawm kev tawm tsam hauv cov kab mob fungal rau cov khoom siv tshuaj tiv thaiv kab mob tau ua rau muaj kev xav tau tshiab rau kev kho tshiab.Caspofungin hmoovyog ib qho piv txwv tseem ceeb ntawm xws li ib tug tshiab compound, hloov cell phab ntsa biosynthesis los ntawm inhibiting lub synthesis ntawm -1,3-D-glucan. Txawm hais tias muaj kev nce qib tseem ceeb hauv kev nkag siab txog cov txheej txheem ntawm kev ua ntawm Aids-058650, nws cov teebmeem ntawm biophysical zog ntawm cov kab mob fungal tseem to taub tsis zoo. Txoj kev tshawb no siv atomic force microscopy (AFM) los ua kom pom tias Cancidas (tm) hloov pauv cov khoom ntawm tes ntawm "Candida albicans". CASPOFUNGIN ua rau muaj kev hloov pauv tseem ceeb hauv cell morphology thiab cov qauv, uas muaj feem cuam tshuam nrog kev txo qis hauv cell phab ntsa txhua yam muaj zog. Tsis tas li ntawd, peb pom tias cov khoom no ua rau muaj kev cuam tshuam loj ntawm cov cell adhesion protein Als1 ntawm lub xovtooj ntawm tes, ua rau muaj zog ntawm cov xov tooj ntawm tes hydrophobicity-ob qho tib si nta uas ua rau cov cell aggregation. Qhov kev coj cwj pwm no tsis tau pom nyob rau hauv cov kab mob poov xab uas tsis muaj Als1, qhia tias cov protein no ua lub luag haujlwm tseem ceeb hauv kev txiav txim siab cov phenotype ntawm "Candida albicans".

 

Caspofungin Metabolized hauv lub siab li cas?

Cancidas (tm) nthuav tawm cov kab mob bactericidal tiv thaiv Candida spp. (xws li triazole- cov kab mob resistant) thiab cov kab mob bacteriostatic tawm tsam Aspergillus spp. Lub pharmacokinetics ntawm Caspofungin yog triphasic thiab nonlinear. Tom qab ntawd, cov khoom yog maj mam tso tawm ntawm cov ntaub so ntswg extravascular thiab maj mam metabolized nyob rau hauv daim siab. Cov khoom no yog hydrolyzed nyob rau hauv daim siab thiab maj mam metabolized los ntawm N-acetylation mus rau hauv ob inactive metabolites; Kev txo koob tshuaj yog pom zoo nyob rau hauv cov mob hnyav hnyav. Aids058650 kuj spontaneously degrades rau qhib -ring compounds.

Zoo li lwm yam echinocandins,Caspofungin hmoovexerts nws cov teebmeem los ntawm noncompetitively inhibiting -(1,3)-D-glucan synthase, ib feem tseem ceeb ntawm fungal cell phab ntsa synthesis; cov enzyme no tsis muaj nyob rau hauv mammalian hlwb.

MF ntawm Caspofungin

Qhov ntom	1.36 g / cm³
Boiling point	1408.1ºC ntawm 760 mmHg
Cov mis mos molecular	C₅₃H₈₉N₉O₁₅
Molecular hnyav	1092.33
Flash point	805.4ºC
Cov huab hwm coj	1091.65
PSA	400
LogP	0.7612
Refractive Index	1.623
Cia tej yam kev mob	2-8 degree

Specification

Muaj ntau txoj kev xa khoom rau koj xaiv

Peb lub zog:

Peb lub tuam txhab tau dhau los ntawm FDA thiab ISO19001 kev tswj hwm qhov system ntawv pov thawj. Thiab peb muaj kev koom tes nrog kev cog lus nrog ntau lub Hoobkas thiab chaw kuaj hauv Suav teb, Peb lub tuam txhab tuaj yeem muabCaspofungin hmoovthiab lwm yam ntawm tus nqi zoo dua. Yog tias koj txaus siab, thov sau ib tsab ntawv.
Peb tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev thauj mus los, tab sis kuj txhawb ntau txoj kev them nyiaj, txawm tias koj siv nyiaj US, euros, Australian las, lossis cov nyiaj hauv zos los ntawm Singapore, Malaysia, Thaib, thiab lwm yam. Peb kuj tuaj yeem txhawb cov txiaj ntsig hauv zos hauv cov cheeb tsam thiab cov tebchaws no. Tsis tas li ntawd, peb kuj txhawb nqa cov npav hauv txhab nyiaj (credit cards, thiab lwm yam) rau kev them nyiaj.

FAQ:

Q1: CASPORFUNGIN yog dab tsitxawv ntawm lwm cov tshuaj tua kab mob?
CASPORFUNGIN yog thawj tus neeg pom zoo los ntawm chav kawm tshiab ntawm cov tshuaj tua kab mob, cov echinocandins. Los ntawm kev tsom mus rau cov phab ntsa ntawm cov kab mob fungal (raws li qhov tsis zoo rau cov kab mob fungal cell membrane), echinocandins nthuav tawm cov txheej txheem tshwj xeeb ntawm kev ua cuam tshuam rau lwm cov tshuaj tiv thaiv kab mob tam sim no.
Q2: Caspofungin puas cuam tshuam rau daim siab?
Caspofungin yog ib feem tshem tawm ntawm daim siab, thiab qhov nce ntawm AUC tau pom nyob rau hauv cov neeg mob uas muaj lub siab tsis txaus. Yog li ntawd, kev txo qis hauv CS-1171 noj koob tshuaj tau pom zoo rau cov neeg mob uas muaj lub siab tsis txaus, raws li kev kwv yees los ntawm Child-Pugh (CP) chav kawm B.
Q3: Puas yog Caspofungin MK-0991hla cov ntshav-b hlwb barrier?

Standard koob tshuaj CAS tsis txaus los kho cov kab mob CNS fungal. MK-0991 qhia tias muaj peev xwm nkag mus rau hauv tib neeg lub paj hlwb (CNS). Hauv kev mob meninges, kev nkag mus ntawm CAS yuav nce ntxiv hauv qee tus neeg mob.

Tsis lees paub: Cov ntaub ntawv luam tawm ntawm lub vev xaib no los ntawm Is Taws Nem, tsis tau txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm cov ntsiab lus. Thov ua tib zoo saib kom paub qhov txawv. Tsis tas li ntawd, cov khoom muab los ntawm peb lub tuam txhab tsuas yog siv rau kev tshawb fawb tshawb fawb. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.

Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais, thov hu rau peb los ntawmEmail :sales6@faithfulbio.com . Peb pab neeg tau cog lus los ua kom tiav kev txaus siab ntawm cov neeg siv khoom.

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