Cyclosporin yog ib qho tshuaj tiv thaiv kab mob muaj zog uas tuaj yeem cuam tshuam cov lus teb ntawm cellular mediators, reversibly inhibit T cell proliferation, thiab tsis inhibit tiam ntawm cov ntshav los yog cuam tshuam rau phagocytic muaj nuj nqi. Yog li ntawd, piv nrog rau lwm yam inhibitors, nws muaj qhov zoo ntawm kev tsis tshua muaj inducing los yog aggravating kab mob.Cyclosporin A hmoovyog ib rab koob dawb zoo li siv lead ua nrog lub melting point ntawm 148-151 degree, soluble nyob rau hauv methanol, ethanol, acetone, ether los yog chloroform, thiab me ntsis soluble nyob rau hauv dej thiab saturated hydrocarbons.
|
Cov khoom |
Txuj |
Kev tshwm sim |
|
Qhov tshwm sim |
Dawb crystalline hmoov |
Ua raws |
|
Solublility |
Ua raws |
Ua raws |
|
Kev txheeb xyuas |
Ua raws |
Ua raws |
|
Poob rau ziab |
2.0%max |
0.6% |
|
Hnyav hlau |
0.002% max |
<0.002% |
|
Tus kheej impurity |
0.7% max |
0.3% |
|
Tag nrho cov impurity |
1.5% max |
1.0% |
|
Lwm yam impurity |
0.1% max |
0.05% |
|
Acetone |
0.5% max |
0.04% |
|
Ethanol |
0.5% max |
0.00% |
|
Ethyl acetate hmoov |
0.5% max |
0.07% |
|
QHIA |
98.5%~101.5% |
99.23% |
|
Kev txiav txim siab: Cov khoom lag luam ua raws li USP36 |
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Cyclosporin A immunosuppressant yog dab tsi?
Pure Cyclosporine yog lipophilic cyclic peptide compound tsim los ntawm 11 amino acids cais los ntawm kab lis kev cai nruab nrab ntawm qee yam Hyphomycetes fungi. Nws belongs rau qeb ntawm cov tshuaj tiv thaiv muaj zog, uas tuaj yeem cuam tshuam cov lus teb ntawm cellular mediators, reversibly inhibit T cell proliferation, tsis inhibit tiam ntawm cov qe ntshav, thiab tsis cuam tshuam rau phagocytic muaj nuj nqi. Yog li ntawd, piv nrog rau lwm yam inhibitors,Cyclosporin A hmoovmuaj qhov zoo ntawm kev ua kom tsis zoo los yog ua rau kis kab mob. Nws yog tsuas yog siv hauv kev kho mob rau kev tiv thaiv kev tsis lees paub hauv lub raum, lub siab, lub plawv, lub ntsws, thiab cov pob txha pob txha hloov, thiab tuaj yeem siv ua ke nrog cov tshuaj hormones adrenal cortex, tab sis yuav tsum tsis txhob siv nrog rau lwm cov tshuaj tiv thaiv kab mob. Nws kuj tseem siv rau qee yam kab mob autoimmune xws li kab mob lupus erythematosus, lupus nephritis, rheumatoid mob caj dab, thiab autoimmune hemolytic anemia. Siv rau kev kho mob xws li uveitis, mob hnyav aplastic anemia, refractory thawj thrombocytopenic purpura, psoriasis, thiab lwm yam.
Txog cov tshuaj pharmacological ntawm cov khoom no?
Cyclosporine tsis ua haujlwm ntawm cov pob txha pob txha, tsis tshua muaj kev cuam tshuam rau B hlwb, thiab tsis muaj qhov cuam tshuam tseem ceeb rau kev ciaj sia ntawm granulocytes ntawm cov tshuaj kho mob. Lub ntsiab mechanism ntawm kev txiav txim ntawmntshiab cyclosporin Ayog tias cyclosporine A tsim ib txoj hauv kev nrog cyclosporine thiab tom qab ntawd ua rau calcineurin, uas nyob ntawm calcium / calcium binding protein, inhibiting dephosphorylation ntawm NF-AT thiab tiv thaiv nws los ntawm kev nkag mus rau hauv lub nucleus, yog li inhibiting zus tau tej cov IL-2 , inhibiting kev tua ntawm NK hlwb, thiab inhibiting tiam ntawm T lymphocytes.
Txoj kev tshawb fawb ntawm cov khoom no yog dab tsi?
Cov khoom no yog cov tshuaj muaj roj-soluble, uas tuaj yeem nqus tau los ntawm kev noj thiab noj cov zaub mov muaj roj. Cov kua tsib tsis txaus, stagnation, ua rau lub plab qeeb qeeb, nce plab hnyuv peristalsis, pancreatic dysfunction thiab fatty dysentery tag nrho cuam tshuam rau kev nqus ntawm cov khoom no.
Kev nqus ntawm qhov ncauj yog qhov tsis sib xws thiab sib txawv ntawm cov neeg sib txawv. Qhov nruab nrab bioavailability yog 30%, tab sisCyclosporin A Hmoovtuaj yeem nce ntxiv nrog rau ncua sijhawm kho thiab nce cov tshuaj noj. Tom qab hloov daim siab, qhov nqus tuaj yeem txo qis hauv cov neeg mob uas muaj kab mob siab lossis mob plab hnyuv. Kev khi tus nqi ntawm cov khoom no nrog cov ntshav plasma yog siab li 90%, feem ntau nrog lipoprotein.
Txawm hais tias nws lub siab loj thiab lub raum toxicity, tsis zoo solubility, nqaim kho Performance index, thiab tsawg bioavailability tau cuam tshuam nws daim ntawv thov ntxiv hauv cov teb no. Txawm li cas los xij, tam sim no tib neeg tab tom sim hloov kho nws cov qauv thiab sib txuas ua ke ntawm cov khoom sib txuas, thiab tshawb nrhiav cov tshuaj tiv thaiv kab mob uas tsis muaj tshuaj lom thiab cov kev mob tshwm sim, lossis cov khoom siv uas tsis muaj tshuaj lom thiab lwm yam kev ua lom neeg txawm tias lawv tsis muaj kev tiv thaiv kab mob.
Muaj ntau txoj kev xa khoom rau koj xaiv
|
Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
|
3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
|
7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
|
|
15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Peb lub zog:
Peb lub tuam txhab tau dhau los ntawm FDA thiab ISO19001 kev tswj hwm qhov system ntawv pov thawj. Thiab peb muaj kev koom tes nrog kev cog lus nrog ntau lub Hoobkas thiab chaw kuaj hauv Suav teb, Peb lub tuam txhab tuaj yeem muabcyclosporin A. ntawm tus nqi zoo dua. Yog tias koj txaus siab, thov sau ib tsab ntawv.
Peb tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev thauj mus los, tab sis kuj txhawb ntau txoj kev them nyiaj, txawm tias koj siv nyiaj US, euros, Australian las, lossis cov nyiaj hauv zos los ntawm Singapore, Malaysia, Thaib, thiab lwm yam. Peb kuj tuaj yeem txhawb cov txiaj ntsig hauv zos hauv cov cheeb tsam thiab cov tebchaws no. Tsis tas li ntawd, peb kuj txhawb nqa cov npav hauv txhab nyiaj (credit cards, thiab lwm yam) rau kev them nyiaj.
Tsis lees paub: Cov ntaub ntawv luam tawm ntawm lub vev xaib no los ntawm Is Taws Nem, tsis tau txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm cov ntsiab lus. Thov ua tib zoo saib kom paub qhov txawv. Tsis tas li ntawd, cov khoom muab los ntawm peb lub tuam txhab tsuas yog siv rau kev tshawb fawb tshawb fawb. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.
Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais, thov hu rau peb los ntawmEmail :sales6@faithfulbio.com . Peb pab neeg tau cog lus los ua kom tiav kev txaus siab ntawm cov neeg siv khoom.
Cim npe nrov: cyclosporin a hmoov cas 59865-13-3, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua hauv Suav teb