Fingolimod Hydrochloride CAS TSIS TAU

Ntau yam sclerosis yog ib yam kab mob uas yuav ua rau lub hlwb thiab tus txha caj qaum (central nervous system) ua rau neeg tsis taus. Cov nqaij mos spasm, cov neeg mob hnyav yuav poob lawv qhov kev sib npaug los yog tshwm sim ntau lub cev muaj zog. Txawm li cas los xij, cov khoom no tsis muaj cov tshuaj zoo hauv qhov ncauj, thiab nws yuav tsum tau mus rau hauv tsev kho mob ntau zaus, uas ua rau muaj teeb meem loj rau kev kho thiab kho cov neeg mob. Raws li thawj cov tshuaj hauv qhov ncauj, Fingolimod hydrochloride daws qhov teeb meem no. Raws li Novartis Pharmaceutical Company, lub chaw tsim tshuaj ntawm cov tshuaj, cov txheej txheem pharmacological ntawmFingolimod hydrochloride hmoovyog thim rov qab. Yog tias cov tshuaj raug tso tseg, cov qib lymphocyte circulating yuav rov zoo li qub. Tam sim no, cov khoom no tau pom zoo muag los ntawm US Food and Drug Administration (FDA). Cov koob tshuaj pom zoo yog 0.5mg qhov ncauj ib hnub ib zaug.

Yuav ua li cas yog lub mechanism ntawm kev txiav txim ntawm Fingolimod Hydrochloride?

Fingolimod Hydrochloride hmoovtau tsim los ntawm kev hloov kho cov qauv ntawm cov khoom siv zoo ntawm ascomycete Cordyceps sinensis (ISP-1). Sib txawv los ntawm lwm cov receptor modulators, nws muaj kev sib koom ua ke nrog rau lwm cov tshuaj tiv thaiv kab mob, uas tuaj yeem hloov cov kev taw qhia ntawm lymphocytes thiab cov synthesis thiab kev qhia ntawm intercellular adhesion molecules.Ntshiab fingolimodyog sphingosine -l-phosphate (s1PR) receptor modulator. Tom qab phosphorylation nyob rau hauv vivo, nws khi rau S1P receptor ntawm lymphocyte nto, uas hloov cov migration ntawm lymphocytes, yaum cov hlwb kom nkag mus rau cov ntaub so ntswg lymphoid, tiv thaiv lawv tawm ntawm lymphoid cov ntaub so ntswg thiab nkag mus rau hauv graft, thiab ces tiv thaiv cov cell los ntawm infiltrating mus rau hauv lub plawv paj hlwb. system (CNS), yog li ua tiav cov txiaj ntsig ntawm kev tiv thaiv kab mob.

Peb tuaj yeem siv cov khoom no kom raug li cas?

Hauv kev kho mob ntawm cov neeg mob uas rov muaj ntau yam sclerosis, peb tsis tas yuav sivFingolimod hydrochlorideraws li qhov tshuaj noj ntawm 0.5 mg / hnub; Nyob rau tib lub sijhawm, thawj koob tshuaj yuav tsum tau saib xyuas raws li qhov xav tau.
1) Saib xyuas cov cim qhia thiab cov tsos mob ntawm bradycardia hauv txhua tus neeg mob tsawg kawg 6 teev tom qab noj thawj zaug, thiab ntsuas pulse thiab ntshav siab txhua teev. Tau txais ECG ua ntej kev tswj hwm thiab thaum kawg ntawm lub sijhawm soj ntsuam.
2) Cov neeg mob lub plawv dhia<45 bpm or newly onset second degree or higher atrioventricular block should be monitored until it is detected and resolved. After administration, patients with the lowest heart rate at the end of the observation period should be monitored until their heart rate increases.
3) Hauv cov neeg mob uas muaj cov tsos mob ntawm bradycardia, kev tshuaj xyuas ECG txuas ntxiv yog pib kom txog thaum cov tsos mob raug daws; Yog tias yuav tsum muaj kev cuam tshuam tshuaj rau kev kho mob bradycardia, kev soj ntsuam ECG txuas ntxiv yuav tsum tau ua thaum hmo ntuj ntawm cov cuab yeej kho mob, thiab thawj koob tshuaj xyuas yuav tsum rov ua dua rau kev tswj hwm thib ob.
4) Cov neeg mob uas muaj kev pheej hmoo siab ntawm cov tsos mob bradycardia lossis lub plawv nres vim muaj kev sib koom ua ke kho mob lossis cov tshuaj sib xyaw ua ke siv txuas ntxiv ECG saib xyuas thaum hmo ntuj
5) Cov neeg mob uas muaj QTc ncua sij hawm ntev ntawm lub hauv paus los yog lub sijhawm soj ntsuam, lossis cov neeg siv tshuaj uas paub tias muaj kev pheej hmoo ntawm cov pob tw ventricular tachycardia, yuav tsum tau saib xyuas ib hmos nrog kev soj ntsuam ECG tas li.

Thaum siv cov khoom no, peb yuav tsum xyuam xim rau dab tsi?

Txawm hais tias, rau lub sijhawm tam sim no, peb tsis tau txais cov lus ceeb toom ntawm overdose mob ntawm cov khoom no. Txawm li cas los xij, ntawm 40 mg / hnub, 5/6 cov neeg mob tau tshaj tawm lub hauv siab mob ceev lossis tsis xis nyob, uas tau ua raws li kev kho mob me me. Tsis tas li ntawd, tsis yog kev lim ntshav lossis kev hloov ntshav ntshav tuaj yeem ua rau cov khoom no raug tshem tawm ntawm lub cev.

Thaum siv cov khoom no, koj yuav tsum tau xyuam xim rau ob yam khoom hauv qab no.

(1) Ketoconazole: Cov neeg mob yuav tsum tau saib xyuas kom zoo vim tias 70% nce ntxiv rau kev kis tus kab mob fingomod thiab muaj kev pheej hmoo siab ntawm kev tsis zoo thaumketoconazoleyog siv systemically tib lub sij hawm.

(2) Tshuaj Tiv Thaiv: Cov tshuaj tiv thaiv uas zam los yog txo qis vim muaj kev pheej hmoo ntawm kev kis kab mob thaum kho fingomod thiab 2 lub hlis tom qab tso tseg.

Muaj ntau txoj kev xa khoom rau koj xaiv

Peb lub zog:

Peb lub tuam txhab tau dhau los ntawm FDA thiab ISO19001 kev tswj hwm qhov system ntawv pov thawj. Thiab peb muaj kev koom tes nrog kev cog lus nrog ntau lub Hoobkas thiab chaw kuaj hauv Suav teb, Peb lub tuam txhab tuaj yeem muabFingolimod Hydrochloridelos yog Ketoconazole. ntawm tus nqi zoo dua. Yog tias koj txaus siab, thov sau ib tsab ntawv.

Peb tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev thauj mus los, tab sis kuj txhawb ntau txoj hauv kev them nyiaj, txawm tias koj siv nyiaj US, euros, Australian las, lossis cov nyiaj hauv zos los ntawm Singapore, Malaysia, Thaib, thiab lwm yam. Peb kuj tuaj yeem txhawb cov txiaj ntsig hauv zos hauv cov cheeb tsam thiab cov tebchaws no. Tsis tas li ntawd, peb kuj txhawb nqa cov npav hauv txhab nyiaj (credit cards, thiab lwm yam) rau kev them nyiaj.

Tsis lees paub: Cov ntaub ntawv luam tawm ntawm lub vev xaib no los ntawm Is Taws Nem, tsis tau txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm cov ntsiab lus. Thov ua tib zoo saib kom paub qhov txawv. Tsis tas li ntawd, cov khoom muab los ntawm peb lub tuam txhab tsuas yog siv rau kev tshawb fawb tshawb fawb. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.

Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais, thov hu rau peb los ntawmEmail :sales6@faithfulbio.com  . Peb pab neeg tau cog lus los ua kom tiav kev txaus siab ntawm cov neeg siv khoom.

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