Khoom Taw Qhia
Dapagliflozin hmoovyog ib yam tshiab ntawm cov tshuaj tiv thaiv kab mob ntshav qab zib thiab thawj SGLT2 inhibitor pom zoo rau kev kho mob ntshav qab zib hom 2. Nws tuaj yeem siv los ua ib qho kev xaiv tseem ceeb hauv kev kho mob ntshav qab zib hom 2 thiab tsim nyog rau cov neeg laus uas muaj ntshav qab zib hom 2 raws li kev noj haus thiab kev tawm dag zog los txhim kho cov ntshav qab zib. Dapagliflozin yog sodium-glucose co-transporter 2 inhibitor. Lub US Food and Drug Administration (FDA) tau pom zoo dapagliflozin rau kev kho mob ntawm hom 2 mob ntshav qab zib mellitus thiab xav kom cov tuam txhab lag luam ua cov kev tshawb fawb tom qab kev lag luam txog kev pheej hmoo ntawm kev siv tshuaj. Txoj kev tshawb no yuav ntsuas cov tshuaj pharmacokinetics, kev ua tau zoo thiab kev nyab xeeb ntawm dapagliflozin hauv cov neeg mob menyuam yaus.
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| Dapagliflozin hmoov Daim duab | Dapagliflozin hmoov MF |
Khoom siv
Dapagliflozin hmoovraug pom zoo rau cov neeg mob uas muaj ntshav qab zib hom 2 thiab paub tseeb tias muaj kab mob plawv lossis ntau yam kab mob plawv kom txo qis kev pheej hmoo ntawm kev mus pw hauv tsev kho mob rau myocardial infarction. Nws tuaj yeem siv los ua ib qho kev kho mob lossis ua ke nrog lwm cov tshuaj (xws li metformin, canagliflozin, saxagliptin, thiab lwm yam). Dapagliflozin xaiv inhibits sodium-glucose co-transporter 2 (SGLT2), txo lub raum qabzib reabsorption, thiab ncaj qha tso tawm cov suab thaj ntau dhau hauv cov zis, yog li txo cov ntshav qab zib hauv cov neeg mob ntshav qab zib hom 2 los kho ntshav qab zib.
A concise and efficient synthesis of the SGLT-2 inhibitor dapagliflozin. The synthetic route uses ethyl C-aryl glycoside 9 as a key intermediate, which is easily crystallized and purified into a crystalline n-propanol solvate with high purity (>98.5%). The tetra-O-unprotected compound 9 can be directly reduced to crude dapagliflozin with high diastereoselectivity. Finally, a pure API with high purity (>99.7%) tau cais tawm thiab ua kom huv.
5-Bromo-2-chlorobenzoic acid yog chlorinated, reacted nrog phenethyl ether kom dhau Friedel-Crafts cov tshuaj tiv thaiv, thiab carbonyl txo kom tau 5-bromo-2-chloro-4' -ethoxydiphenylmethane, uas tom qab ntawd condensed nrog 2,3,4,6-tetra-O-trimethylsilyl-D-pyranogluconoic acid-1,5-lactone, reacted nrog cov anomeric carbon hydroxyl ether tshuaj phau ntawv, thiab tiv thaiv kom tau txais 2-chloro-5-(1- methyl)benzoic acid, uas yog txo nrog Et3SiH/BF3·OEt2 kom tshem tawm cov methoxy pawg, esterified nrog acetic anhydride, thiab hydrolyzed kom tau dapagliflozin.
Khoom Specification
| Yam khoom | Txuj | Cov qhabnias xeem |
| Qhov tshwm sim | Dawb rau lub teeb daj hmoov | Ua raws |
| Qhov Loj | 100% dhau 80 mesh | Ua raws |
| Poob rau ziab | Tsawg dua lossis sib npaug rau 3.0% | 0.021 |
| Purity | >98.00% | 0.9856 |
| Total Heavy Metals | Tsawg dua lossis sib npaug li 10ppm | <10ppm |
| Raws li | Tsawg dua los yog sib npaug rau 1.0ppm | <0.1ppm |
| Pb | Tsawg dua los yog sib npaug rau 1.0ppm | <0.2ppm |
| Cd | Tsawg dua lossis sib npaug rau 0.5ppm | Tsis zoo |
| Hg | Tsawg dua los yog sib npaug rau 1.0ppm | Tsis zoo |
| Tag Nrho Phaj suav | Tsawg dua los yog sib npaug rau 1,000cfu/g | <15cfu/g |
| Pwm thiab Poov xab | Tsawg dua lossis sib npaug li 100cfu / g | <5cfu/g |
| E. Coli | Tsawg dua lossis sib npaug li 1cfu / g | 0.003cfu/g |
| Salmonella | Tsawg dua lossis sib npaug li 1cfu / g | Tsis zoo |
| Ua xua | - | Tsis zoo |
| GMO | - | Tsis zoo |
| Cov tshuaj tua kab residue | Tsawg dua lossis sib npaug li 1cfu / g | Tsis zoo |
| Ib feem siv | Coptis chinasis | Rhizome |
| Ua raws li tus qauv kev lag luam |
Yuav Ua Li Cas Kom Tau Txais Cov QauvDapagliflozin hmoov?
Txais tos xa ib qho kev nug rausunny@faithfulbio.comtxhua lub sijhawm rau tus qauv dawb yog tias koj xav tau APIDapagliflozin hmoov.
Qhov zoo tshaj plaws Dapagliflozin hmoov Chaw tsim tshuaj paus thiab tsum
Faithfulbio muaj kev paub dhau los hauv kev xa tawm cov ntaub ntawv raw thiab tau tsim kev sib raug zoo thiab kev koom tes ntev nrog peb cov neeg siv khoom. Peb ib txwm muab cov khoom zoo thiab kev pabcuam ua ntej. Yog tias koj muaj cov khoom siv raw khoom xav tau, thov hu rau peb. Peb tuaj yeem lees paub qhov kev txiav txim nrog koj raws li koj qhov yuav khoom ntau. Peb kuj txhawb peb txoj kev koom tes thawj zaug pib los ntawm cov qauv. Tsis tas li ntawd, peb txoj kev thauj mus los sai thiab nyab xeeb kuj ua rau koj tshem tawm cov teeb meem ntawm kev lis kev cai.
Peb muaj kev ntseeg siab ntawm peb cov khoom zoo, tab sis yog tias muaj teeb meem tom qab muag, peb yuav teb sai li sai tau thiab daws lawv nrog koj txoj hauv kev zoo tshaj plaws.
Vim Li Cas Xaiv FaithfulbioDapagliflozin hmoov?
Faithfulbio tshwj xeeb hauvDapagliflozin hmoovrau ntau xyoo, peb muab cov khoom ntawm tus nqi sib tw, thiab peb cov khoom yog qhov zoo tshaj plaws, vim tias peb nruj heev hauv cov khoom tsim thiab kev sim, thiab muaj kev ua tiav thiab paub tab. Tsis tas li ntawd, peb cov neeg ua haujlwm Cov lus hais rau cov khoom muaj kev sib tw heev.
Muaj ntau txoj kev xa khoom rau koj xaiv
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Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
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3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
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7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
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15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
ua siab zoo ceeb toom:SivDapagliflozin hmoovrau kev tshawb fawb nkaus xwb. Txhua lub tebchaw muaj kev pheej hmoo. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv. Tsis tas li ntawd, cov lus piav qhia saum toj no ntawm qhov sib xyaw yog los ntawm cov ntaub ntawv online. Yog tias muaj kev ua txhaum cai, thov hu rau peb kom tshem tawm.
Qhov twg Yuav Dapagliflozin hmoov?
Cia li xa email rausunny@faithfulbio.com, lossis xa koj qhov yuav tsum tau ua hauv daim ntawv hauv qab, peb muaj kev pabcuam txhua lub sijhawm!
Cim npe nrov: dapagliflozin hmoov cas 461432-26-8, Suav teb, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, kev muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua nyob rau hauv Tuam Tshoj