Topiroxostat hmoovyog ib tug uas tsis yog purine xaiv xanthine oxidoreductase inhibitor tsim los ntawm Fuji Pharmaceutical Co., Ltd. nyob rau hauv Nyiv, uas selectively thiab reversibly inhibits xanthine oxidoreductase thiab txo cov ntshav uric acid. Cov kev tshawb fawb soj ntsuam tau pom tias FYX-051 muaj qhov cuam tshuam loj heev rau ob qho tib si oxidative thiab txo qis XORs, tsis muaj kev cuam tshuam rau lwm cov pyrimidine purine metabolic enzymes. Nws cov kev sib tw thiab kev xaiv inhibitory cuam tshuam ua rau nws muaj kev nyab xeeb dua, muaj zog dua, thiab ruaj khov dua hauv kev txo cov uric acid.
|
检验项目Test khoom |
标准规定Acceptancecriteria |
检验结果 Cov |
|
|
性状 Cov cim |
外观Appearance |
应为白色至淡黄色结品性粉末 Whiteto teeb daj crystalline hmoov |
符合规定 Conform |
|
溶解度 Solubilioy |
在N-甲基吡格烷酮中溶解,在2甲基亚砜 中路溶,在水中几乎不溶 |
符合规定 Conform | |
|
鉴别 Kev txheeb xyuas |
HPLC yog qhov zoo tshaj plaws |
主峰保留时间应与对照品一致. Lub sijhawm khaws cia ntawm lub ncov tseem ceeb yuav tsum ua raws li CRS |
与对照品一致 Ua raws li CRS |
|
红外光谱 IR |
应与对照品图谱一致 Infrared absorption spectrum ntawm cov khoom yuav tsum ua raws li CRS |
与对照品图谱一致 Ua raws li CRS |
|
|
粉末X射线衍射 Powder x-raydiffraction |
本品的X射线粉末衍射图谱应于对照品的 图谱 [行射角(2θ) 分别为 10.3 degree, 16.1" 20.6 degree, 25.9 degree 与26.9] Ib qho XRD ntawm cov khoom yuav tsum ua raws li CRS ntawm [20 is10.3,16.1 degree, 20.6 degree, 25,9 txog 26.9 degree) |
符合规定 Conform |
|
|
Cov ntaub ntawv PSD |
d({0}}.9) 不得过30μm d(0.9) Tsawg dua los yog sib npaug li 30μm |
20μm |
|
|
有关物质 Cov khoom muaj feem xyuam |
杂质B不得过{{0}}.10% Impurity B Tsawg dua lossis sib npaug rau 0.10% |
未检出 N.D. |
|
|
杂质C不得过{{0}}.10% Impuriny C Tsawg dua lossis sib npaug li 0.10% |
0.02% |
||
|
杂质D不得过{{0}}.10% Impurity D Tsawg dua lossis sib npaug rau 0.10% |
0.02% |
||
|
杂质E不得过{{0}}.10% Impuriy ES0.10% |
未检出 N.D. | ||
|
其他单个杂质不得过{{0}}.10% Cov impurities Tsawg dua lossis sib npaug rau 0.10% |
0.03% |
||
|
总杂质不得过{{0}}.5% Tag nrho cov impurities Tsawg dua lossis sib npaug rau 0.5% |
0.09% |
||
| 残留溶剂(1) Residual Sohents (1) |
甲醇不得过{0}}.3% Methanol Tsawg dua lossis sib npaug li 0.3% |
未检出 N.D. | |
|
异丙醇不得过{{0}}.5% isopropanol Tsawg dua lossis sib npaug li 0.5% |
未检出 N.D. |
||
|
2氯甲烷不得过0.06% dichloromethane Tsawg dua lossis sib npaug rau 0.06% |
未检出 N.D. |
||
| 残留溶剂(1) Residual Sohents (1) |
N-甲基吡路烷酮不得过0.053% N-methylpyrrolidone Tsawg dua lossis sib npaug li 0.053% |
0.004% |
|
| 水分 ater |
不得过0.5% S0.5% |
0.14% | |
| 炽灼残渣 Residue ntawm ignition |
不得过{{0}}.1% Tsawg dua lossis sib npaug li 0.1% |
0.04% | |
| 重金属 Heay Metals |
不得过百万分之2十 Tsawg dua los yog sib npaug rau 20ppm |
符合规定 Conform | |
| 含量测定 Assay |
按无水物计算, 含Ci₃HaNg应为 98.0%~102.0% 98. 0%~102.0% |
100.3% |
|
|
结论: Xaus: |
本品按粉碎后托匹司他QS-00-149(04版)质量标准检验, 结果符合规定. Cov khoom no tau raug tshuaj xyuas raws li tus qauv zoo QS-00-149 (version 04) ntawm Topiroxostat tom qab crushing, thiab cov txiaj ntsig tau raws li qhov xav tau |
||
Yuav ua li cas xaiv uric acid txo cov khoom?
Muaj ntau ntau yam khoom los txo cov uric acid, uas feem ntau yog muab faib ua ob pawg: thawj qeb yog tshuaj los inhibit uric acid ntau lawm. Qhov thib ob hom tshuaj los txhawb uric acid excretion. Qhov thib ib feem ntau yog siv Topiroxostat, febuxostat thiab allopurinol, thaum lub thib ob feem ntau yog siv benzbromarone.
1. topiloric yog ib qho inhibitor tshiab ntawm xanthine oxidase, uas yog superior rau allopurinol hauv kev txo cov uric acid, tab sis qis dua febuxostat. Txawm li cas los xij, FYX 051 muaj kev cuam tshuam tsawg dua ntawm cov hlab plawv, thiab tuaj yeem txo cov qib hyperuricemia ntawm cov neeg mob uas muaj kab mob raum III thiab gout. Tam sim no,Topiroxostat hmoovyog thawj qhov kev xaiv rau kev kho mob mus sij hawm ntev ntawm hyperuricemia hauv tsev kho mob.
2. Febuxostat yog cov tshuaj ib txwm siv los txo cov uric acid, tab sis nws muaj kev puas tsuaj rau daim siab thiab lub raum ua haujlwm thiab tuaj yeem ua rau muaj kev pheej hmoo ntawm cov hlab plawv. Hauv particular, hyperuricemia yog ib hom kab mob ntev. Kev siv lub sijhawm ntev ntawm cov khoom no yuav tsum tau saib xyuas lub siab thiab lub raum ua haujlwm tsis tu ncua thiab tshuaj xyuas kab mob plawv. Txawm li cas los xij, nws cov txiaj ntsig ntawm kev txo cov uric acid sai heev, yog li nws tuaj yeem txo qis thaum siv.
3. Allopurinol feem ntau inhibits qhov tsim ntawm uric acid, feem ntau kho hyperuricemia thiab gout, thiab kuj muaj qee yam cuam tshuam rau uric acid raum calculi. Txawm li cas los xij, cov khoom no tuaj yeem ua rau tawv nqaij ua xua.
4. Lub mechanism ntawm kev txiav txim ntawm Exurate yog los txhawb lub excretion ntawm uric acid. Thiab cov nyhuv yog zoo kawg li. Feem ntau, cov neeg mob yuav tsum tau noj nws los ntawm ib koob me me, thiab cov koob tshuaj tuaj yeem hloov kho raws li tus neeg mob qhov xwm txheej hauv kev kho mob tom qab. Txawm li cas los xij, nws yog ib qho tsim nyog yuav tsum tau saib xyuas cov ntshav uric acid tsis tu ncua thaum siv nws kom tsis txhob muaj cov ntshav uric acid txo qis los yog tuaj yeem rov ua dua ntawm gouty mob caj dab. Thaum lub sij hawm thov, cov neeg mob yuav tsum tau haus dej kom ntau kom tso zis tso zis thiab tsis txhob tsim cov uric acid crystals.
Rau cov neeg mob gout, txawm hais tias hom tshuaj twg yog siv los txo cov uric acid, cov tshuaj uric acid yuav tsum tau tswj tsis pub dhau 360. Yog tias muaj pob zeb gout, cov uric acid yuav tsum tau tswj tsis pub dhau 300, thiab kev tswj cov uric acid yuav tsum. ua tus kheej ntau dua ua ke nrog tus kws kho mob cov lus qhia thiab koj tus kheej qhov xwm txheej tiag tiag. Peb lub tuam txhab koom nrog ntau yam khoom siv los tiv thaiv gout. Ntxiv rau qhov saum toj no Topiroxostat thiab Febuxostat, peb kuj tuaj yeem muab cov khoom lag luam xws li D-Glucosamine hydrochloride, Etoricoxib, Phenylbutazone sodium thiab lawv cov derivatives. Yog tias koj txaus siab, thov hu rau peb ntawmemail: sales6@faithfulbio.comsai li sai tau.
|
|
|
|
|
| Topiroxostat | Febuxostat | Allopurinol | benzbromarone tshuaj |
Yuav Topiroxostat puas muaj kev phiv tshuaj?
Topiroxostat yog cov khoom siv kho mob rau kev kho mob gout thiab hyperuricemia. Zoo li lwm yam khoom, nws kuj yuav ua rau qee qhov kev mob tshwm sim. Ua ntej txiav txim siab seb yuav siv cov khoom no, nws yog ib qho tseem ceeb heev rau cov neeg mob thiab cov kws kho mob kom paub txog nws cov kev mob tshwm sim. Tshooj lus no yuav qhia tshwj xeeb txog cov kev mob tshwm sim tshwm sim ntawmTopiroxostat hmoovthiab muab cov ntaub ntawv tseem ceeb kom nkag siab zoo dua thiab tswj cov teeb meem uas yuav tshwm sim.
1. Cov tshuaj tiv thaiv kab mob plab
Topiroxostat tuaj yeem ua rau muaj kev phiv ntawm txoj hnyuv, xws li xeev siab, ntuav, raws plab thiab plab zom mov. Cov kev mob tshwm sim no feem ntau yog luv luv thiab tshwm sim thaum ntxov ntawm kev kho mob. Yog tias cov tsos mob no tshwm sim los yog hnyav zuj zus, cov neeg mob yuav tsum hu rau tus kws kho mob kom ntsuam xyuas thiab tawm tswv yim.
2. Ua kom lub siab ua haujlwm enzymes
Qee cov neeg mob tau tshaj tawm txog kev nce hauv siab ua haujlwm enzymes thaum siv Topiroxostat. Qhov no tej zaum yuav yog vim muaj cov tshuaj ntawm lub siab. Nws yog ib qho tseem ceeb los saib xyuas daim siab ua haujlwm, thiab xyuas lub siab ua haujlwm tsis tu ncua thaum kho kom paub tseeb tias tsis muaj qhov txawv txav. Cov neeg mob yuav tsum ceeb toom rau lawv cov kws kho mob tam sim ntawd yog tias daim siab enzymes nce siab lossis lwm cov tsos mob ntawm lub siab tshwm sim.
3. Kev tsis haum tshuaj
Qee tus neeg mob yuav muaj kev fab tshuaj rau Topiroxostat, nrog rau cov pob khaus, urticaria, ua tsis taus pa, caj pas nruj thiab lub ntsej muag o. Yog tias muaj kev fab tshuaj, tus neeg mob yuav tsum tsis txhob siv tshuaj tam sim ntawd thiab nrhiav kev pab kho mob.
4. Lwm yam kev mob tshwm sim
Ntxiv rau cov kev mob tshwm sim uas tau hais los saum toj no, Topiroxostat kuj tseem tuaj yeem ua rau lwm yam kev mob tshwm sim, xws li mob taub hau, qaug zog, mob nqaij thiab mob pob qij txha. Yog tias cov neeg mob muaj cov tsos mob txawv txawv lossis tsis xis nyob thaum siv Topiroxostat, lawv yuav tsum sab laj nrog kws kho mob txhawm rau tshuaj xyuas thiab cov lus qhia ntxiv.
Muaj ntau txoj kev xa khoom rau koj xaiv
|
Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
|
3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
|
7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
|
|
15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Peb lub zog:
Peb lub tuam txhab tau dhau los ntawm FDA thiab ISO19001 kev tswj hwm qhov system ntawv pov thawj. Thiab peb muaj kev koom tes nrog kev cog lus nrog ntau lub chaw tsim khoom thiab chaw soj nstuam hauv Suav teb, Peb lub tuam txhab tau koom nrog ntau qhov kev txhim kho los tiv thaiv gout. Ntxiv rau qhov saum toj no Topiroxostat thiab Febuxostat, peb kuj tuaj yeem muab cov khoom lag luam xws li D-Glucosamine hydrochloride, Etoricoxib, Phenylbutazone sodium thiab lawv cov derivatives. Yog tias koj txaus siab, thov hu rau peb.
Peb tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev thauj mus los, tab sis kuj txhawb ntau txoj hauv kev them nyiaj, txawm tias koj siv nyiaj US, euros, Australian las, lossis cov nyiaj hauv zos los ntawm Singapore, Malaysia, Thaib, thiab lwm yam. Peb kuj tuaj yeem txhawb cov txiaj ntsig hauv zos hauv cov cheeb tsam thiab cov tebchaws no. Tsis tas li ntawd, peb kuj txhawb nqa cov npav hauv txhab nyiaj (credit cards, thiab lwm yam) rau kev them nyiaj.
Tsis lees paub: Cov ntaub ntawv luam tawm ntawm lub vev xaib no los ntawm Is Taws Nem, tsis tau txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm cov ntsiab lus. Thov ua tib zoo saib kom paub qhov txawv. Tsis tas li ntawd, cov khoom muab los ntawm peb lub tuam txhab tsuas yog siv rau kev tshawb fawb tshawb fawb. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.
Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais, thov hu rau peb los ntawmEmail :sales6@faithfulbio.com . Peb pab neeg tau cog lus los ua kom tiav kev txaus siab ntawm cov neeg siv khoom.
Cim npe nrov: topiroxostat hmoov cas 577778-58-6, Suav teb, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, kev muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua nyob rau hauv Tuam Tshoj