Khoom Taw Qhia
Epalrestat hmoovyog tsaus liab koob-puab crystals nrog ib tug tsis hnov tsw thiab iab saj. Nws yog yooj yim soluble nyob rau hauv tetrahydrofuran, kuj soluble nyob rau hauv dimethylformamide, kuj insoluble nyob rau hauv methanol, ethanol, ethyl acetate los yog acetone, insoluble nyob rau hauv chloroform los yog ether, thiab yuav luag insoluble nyob rau hauv dej. Lub melting point yog 210-217 degree (ethanol-dej). Tam sim no nws tsuas yog hom tshiab ntawm aldose reductase (AR) inhibitor. Nws txhim kho cov tsos mob ntawm tus mob (kev mob loog, mob) thiab cov hlab ntsha tsis ua haujlwm ntawm cov ntshav qab zib peripheral neuropathy los ntawm inhibiting qhov tsim ntawm sorbitol. Nws yog ib qho tshuaj siv los kho mob ntshav qab zib neuropathy. Nws yog siv los kho cov ntshav qab zib thiab nws cov teeb meem, xws li neuropathy, corneal epitheliopathy, retinopathy thiab microangiopathy.
|
|
|
| epalrestat hmoov Daim duab | Epalrestat hmoov MF |
Khoom siv
epalrestat hmoovyog siv los tiv thaiv, txhim kho thiab kho cov kab mob peripheral paj hlwb (tshem tawm, mob), vibration paresthesia thiab lub plawv dhia txawv txav cuam tshuam nrog ntshav qab zib. Raws li nws cov tshuaj sawv cev, epalrestat tuaj yeem txo qhov sib xyaw ntawm fructose thiab sorbitol hauv cov hlwb los ntawm kev thim rov qab inhibiting kev ua haujlwm ntawm aldose reductase, rov ua haujlwm ntawm Na+-K+-ATPase thiab inositol, nce qhov tsim ntawm NO. nyob rau hauv endothelial hlwb, inhibit protein kinase C signaling pathway, endothelial cell adhesion, siab qab zib-mediated qhia ntawm neutrophils thiab endothelial adhesion yam, thiab txo cov carboxymethyl lysine khoom ntawm cov neeg mob ntshav qab zib, yog li kho cov kab mob xws li ntshav qab zib thiab nws cov teeb meem.
Epalrestat (EPL) yog carboxylic acid derivative, uas plays lub luag haujlwm tseem ceeb hauv kev kho mob ntshav qab zib mellitus mob ntev (neuropathy, nephropathy, cardiopathy thiab retinopathy). Lub siab hauv cov neeg mob ntshav qab zib los ntawm kev txo qis lipid peroxidase concentration hauv cov ntshav liab.
EPL nthuav tawm tsis zoo solubility thiab dissolution tus nqi belongs rau Class II ntawm BCS system ntawm kev faib tawm.
Yog li ntawd, nws yog ib qho tsim nyog yuav tsum tau ua kom muaj kev sib cais ntawm EPL uas yuav muaj kev cuam tshuam zoo rau lub qhov ncauj bioavailability. Ntxiv mus, nws yuav tsum tau ua kom pom EPL cov tshuaj pharmacokinetic los txiav txim siab nws cov tshuaj pharmacodynamic. Txawm hais tias EPL yog siv los kho cov mob ntshav qab zib, tsuas yog qee qhov kev tshawb fawb pharmacokinetic tau luam tawm.
Khoom Specification
| Cov khoom kuaj | Specifications | Cov txiaj ntsig |
| Yam ntxwv | Tsaus liab koob-puab crystals | Ua raws |
| Solubility | Dawb soluble hauv dej, xyaum insoluble hauv acetone, ethanol, trichloromethane thiab ether. | Ua raws |
| Cov khoom muaj feem xyuam | Tag nrho impurities: Tsawg dua lossis sib npaug rau 0.5% | 0.07% |
| Poob rau ziab | Tsawg dua lossis sib npaug rau 0.5% | 0.10% |
| Residue ntawm ignition | Tsawg dua lossis sib npaug rau 0.1% | 0.04% |
| Cov hlau hnyav | Tsawg dua lossis sib npaug li 10ppm | 10 ppm |
| Desicchlora | Ob lub kua yuav tsum tau ntshiab | Ua raws |
| Kev kuaj carbonization | Yuav tsum tsis txhob tob tshaj qhov kev siv tshuaj | Ua raws |
| Microbial txwv | E.coli: Tsis kuaj pom | Ua raws |
| Assay | 99.00% | 99.30% |
| Xaus | Ua raws li tus qauv kev lag luam | |
Yuav Ua Li Cas Kom Tau Txais Cov QauvEpalrestat hmoov?
Txais tos xa ib qho kev nug rausunny@faithfulbio.comtxhua lub sijhawm rau tus qauv dawb yog tias koj xav tau APIEpalrestat hmoov.
Qhov zoo tshaj plaws Epalrestat hmoov Chaw tsim tshuaj paus thiab tsum
Faithfulbio muaj kev paub dhau los hauv kev xa tawm cov ntaub ntawv raw thiab tau tsim kev sib raug zoo thiab kev koom tes ntev nrog peb cov neeg siv khoom. Peb ib txwm muab cov khoom zoo thiab kev pabcuam ua ntej. Yog tias koj muaj cov khoom siv raw khoom xav tau, thov hu rau peb. Peb tuaj yeem lees paub qhov kev txiav txim nrog koj raws li koj qhov yuav khoom ntau. Peb kuj txhawb peb txoj kev koom tes thawj zaug pib los ntawm cov qauv. Tsis tas li ntawd, peb txoj kev thauj mus los sai thiab nyab xeeb kuj ua rau koj tshem tawm cov teeb meem ntawm kev lis kev cai.
Peb muaj kev ntseeg siab ntawm peb cov khoom zoo, tab sis yog tias muaj teeb meem tom qab muag, peb yuav teb sai li sai tau thiab daws lawv nrog koj txoj hauv kev zoo tshaj plaws.
Vim Li Cas Xaiv FaithfulbioEpalrestat hmoov?
Faithfulbio tshwj xeeb hauvEpalrestat hmoovrau ntau xyoo, peb muab cov khoom ntawm tus nqi sib tw, thiab peb cov khoom yog qhov zoo tshaj plaws, vim tias peb nruj heev hauv cov khoom tsim thiab kev sim, thiab muaj kev ua tiav thiab paub tab. Tsis tas li ntawd, peb cov neeg ua haujlwm Cov lus hais rau cov khoom muaj kev sib tw heev.
Muaj ntau txoj kev xa khoom rau koj xaiv
|
Tsheb thauj mus los |
Shipping txoj kev |
Cargo hnyav xav tau |
Qhov zoo |
|
3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau qis dua 50kg. |
Peb muaj warehouses nyob rau hauv lub teb chaws Yelemees thiab California, teb chaws USA, |
|
7-15 hnub |
Los ntawm Cua |
Haum rau ntau tshaj 50kg. |
|
|
15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
ua siab zoo ceeb toom:SivEpalrestat hmoovrau kev tshawb fawb nkaus xwb. Txhua lub tebchaw muaj kev pheej hmoo. Thov nrog koj tus kws kho mob tham thiab kawm txog cov kev tshawb fawb muaj ua ntej siv. Tsis tas li ntawd, cov lus piav qhia saum toj no ntawm qhov sib xyaw yog los ntawm cov ntaub ntawv online. Yog tias muaj kev ua txhaum cai, thov hu rau peb kom tshem tawm.
Yuav Ua Li Cas Epalrestat hmoov?
Cia li xa email rausunny@faithfulbio.com, lossis xa koj qhov yuav tsum tau ua hauv daim ntawv hauv qab, peb muaj kev pabcuam txhua lub sijhawm!
Cim npe nrov: epalrestat hmoov cas 82159-09-9, Suav teb, lwm tus neeg, manufacturers, hoobkas, customized, lag luam wholesale, yuav, nqe, tej, ntshiab, tsim, luv nqi, kev muag, Tshuag, dawb qauv, raw hmoov, raw khoom, ua nyob rau hauv Tuam Tshoj