Glimepiride hmoov CAS 93479-97-1

Glimepiride hmoovyog ib tug dawb los yog dawb-zoo li odorless crystal nrog cov tshuaj formula C24H34N4O5S. Cov khoom no yog soluble hauv chloroform, me ntsis soluble hauv ethanol, yuav luag insoluble hauv dej los yog 0.1mol/L hydrochloric acid tov thiab me ntsis soluble nyob rau hauv 0.1mol/L sodium hydroxide tov. Raws li qhov no, peb tuaj yeem kuaj qhov zoo ntawm cov khoom. Coj ethanol ua piv txwv. Hauv thawj kauj ruam, peb siv cov khoom tsim nyog no, ntxiv ethanol kom yaj thiab dilute nws los ua cov tshuaj uas muaj li ntawm 10µg ib ml, thiab ntsuas nws raws li ultraviolet-pom spectrophotometry (Txoj cai. 0401), thiab nws muaj qhov nqus siab tshaj plaws ntawm lub wavelength ntawm 228nm. Kauj Ruam 2: Lub infrared absorption spectrum ntawm cov khoom no yuav tsum ua raws li kev tswj hwm spectrum (Spectrum Set 1085). Qhov thib peb kauj ruam yog noj li 0.1g ntawm cov khoom no thiab 0.2g ntawm poov tshuaj nitrate, sib tov, sov lawv kom carbonized thiab ashed, cia lawv txias, ntxiv 10mL dej rau cov seem kom yaj lawv, lim lawv, thiab cov filtrate qhia pom cov tshuaj tiv thaiv ntawm sulfate (txoj cai 0301).

Dab tsi yog qhov ua tau zoo thiab kev phiv ntawm glimepiride?

Glimepiride yog ib qho khoom noj khoom haus uas tuaj yeem noj ncaj qha, tab sis nws yuav tsum raug sau tseg tias nws tsuas yog siv tau rau hom 2 mob ntshav qab zib xwb tab sis tsis yog rau hom 1 mob ntshav qab zib.
Lub luag haujlwm tseem ceeb ntawmglimepiride hmoovyog kom txo cov ntshav qab zib, txhim kho cov tshuaj insulin, txo cov tshuaj insulin, txhawb kev tswj qhov hnyav thiab txhim kho cov ntshav lipid. Cov kev mob tshwm sim feem ntau yog mob plab hnyuv, lactic acidosis, vitamin B12 tsis txaus, lub raum tsis txaus, tsis haum tshuaj thiab lwm yam. Thov tshawb xyuas qhov kev tshuaj ntsuam hauv qab no kom paub meej:

Ua ntej, qhov ua tau zoo thiab lub luag haujlwm:

1. Txo cov ntshav qab zib: glimepirid yog cov tshuaj metformin, uas tuaj yeem txo cov piam thaj hauv cov ntshav los ntawm kev ua kom cov leeg nqaij rhiab heev rau cov piam thaj thiab txo cov ntshav qabzib hauv lub siab.

2. Txhim kho cov tshuaj insulin rhiab heev: amary pab txhim kho lub cev cov lus teb rau insulin, kom insulin tuaj yeem thauj cov piam thaj mus rau hauv cov hlwb kom txo cov ntshav qab zib.

3. Txo cov tshuaj insulin tsis kam: AMARYL tuaj yeem txo qhov tsis kam ntawm cov ntaub so ntswg rau insulin thiab pab txhim kho kev ua haujlwm ntawm insulin.

4. Txhawb nqa kev tswj qhov hnyav: Piv nrog rau lwm cov tshuaj tiv thaiv kab mob, cov ntsiav tshuaj glimepiride feem ntau tsis ua kom pom tseeb qhov hnyav, uas yuav pab tau rau kev tswj qhov hnyav.

5. Txhim kho cov ntshav lipid: Cov kev tshawb fawb tau pom tias GlimperideTej zaum yuav muaj txiaj ntsig zoo ntawm kev txo cov roj cholesterol thiab triglyceride.

Qhov thib ob, qhov tshwm sim tuaj yeem tshwm sim:

1. Kev tsis xis nyob hauv plab: Cov kev mob tshwm sim feem ntau muaj xws li mob plab, xeev siab, raws plab thiab tsis qab los noj mov.

2. Lactic acidosis: Txawm hais tias qhov tshwm sim tsawg, CLIMEPIRIDE tuaj yeem ua rau lactic acidosis, uas yog ib qho mob hnyav tab sis tsis tshua muaj tshwm sim thiab yuav tsum tau kho sai.

3. Vitamin B12 tsis txaus: Kev siv Glimpiride mus ntev yuav txo qhov nqus ntawm vitamin B12, yog li ua rau muaj kev pheej hmoo ntawm vitamin B12 tsis txaus.

4. Lub raum tsis txaus: Qee zaum, Grimepride tuaj yeem muaj kev cuam tshuam rau lub raum ua haujlwm.

5, kev tsis haum tshuaj: cov tib neeg yuav muaj kev fab tshuaj rau cov khoom xyaw hauv cov tshuaj, xws li pob khaus, urticaria, o lossis ua pa luv.

Tsis tas li ntawd, nws yuav tsum tau muab sau tseg tias qhov kev tsis zoo ntawm cov khoom yuav txawv ntawm ib tus neeg mus rau ib tus neeg, yog li txhua qhov teeb meem txawv txawv yuav tsum tau saib xyuas thiab tham nrog koj tus thawj saib xyuas thiab tus kws kho mob tam sim ntawd thaum tshawb nrhiav thiab siv. Peb lub tuam txhab tuaj yeem tsis tsuas yog muab ntau hom II cov khoom lag luam hypoglycemic xws li Grimepride thiab Glipizide, tab sis kuj tseem muaj cov khoom lag luam ntws thiab qis, xws li Methyl carbamate thiab 3-Ethyl-4-methyl-3-pyrrolin. -2-ib. Yog tias koj txaus siab, thov hu rau peb ntawmemail:sales6@faithfulbio.com

Cov ntaub ntawv khoom:

Lub mechanism ntawm kev txiav txim ntawm cov khoom no yog dab tsi?

Glimepiride yog qhov thib peb tiam sulfonylurea cov tshuaj tiv thaiv kab mob ntev ntev. Zoo li txhua yam sulfonylureas, nws yog ib qho tshuaj insulin secretagogue, thiab lub luag haujlwm tseem ceeb ntawm nws cov nyhuv hypoglycemic yog los txhawb cov islet hlwb kom tso cov tshuaj insulin, ib feem txhim kho qhov rhiab heev ntawm cov ntaub so ntswg ib puag ncig rau insulin, thiab txhawb kev nce ntawm insulin receptor kev ua haujlwm hauv hlwb kom txo cov ntshav. qab zib. Hauv kev nthuav dav, nws cov txheej txheem ntawm kev ua haujlwm yog tias nws khi rau sulfonylurea receptor (cov protein nrog cov txheeb ze molecular hnyav ntawm 6.5 × 104) ntawm pancreatic -cells, uas yog txuas nrog ATP-sensitive K + (KATP) channel, uas ua rau kaw KATP. channel, depolarization ntawm cell membrane, qhib lub voltage-dependent calcium channel, influx ntawm Ga2+, tso tawm ntawm insulin thiab inhibition ntawm hepatic qabzib synthesis.

Dab tsi yog qhov zoo ntawm glimepiride piv nrog glibenclamide?

Tsis yog txhua cov tshuaj sulfonylurea theem nrab muaj tib txoj kev pheej hmoo ntawm hypoglycemia. Raws li kev sim cov ntaub ntawv txheeb cais, qhov tshwm sim ntawm hypoglycemia hauv glibenclamide yog siab li 20-30%, thaum qhov tshwm sim ntawm hypoglycemia hauv glimepiride tsuas yog 2% mus rau 4%. Raws li cov kev tshawb fawb soj ntsuam, qhov laj thawj yog vim li cas cov khoom no ua rau tsis tshua muaj ntshav qab zib tsawg yog tias nws khi thiab cuam tshuam nrog cov tshuaj insulin sai dua li glimepiride.
Glibenclamide tuaj yeem cuam tshuam nrog cov tshuaj insulin secretion homeostasis inhibition los tiv thaiv hypoglycemia, thaum glimepiride tsis ua. Tsis tas li ntawd, glibenclamide tuaj yeem txo qhov tso tawm ntawm glucagon los tiv thaiv hypoglycemia, thaum glimepiride tsis ua.
Meanwhile, recent studies have shown that different sulfonylurea coal based drugs have varying affinities for KATP. The order is roughly as follows: glibenclamide=glimepiride>tolbutamide>Chlorpropamide. Tsis tas li ntawd, glimepiride tuaj yeem ua rau cov ntshav qabzib nce siab los ntawm txoj hauv kev uas tsis yog insulin, uas tuaj yeem yog vim muaj kev nthuav qhia ntau ntxiv ntawm cov piam thaj thauj mus rau 1 thiab 4 cov protein. Tsis tas li ntawd, cov txiaj ntsig ntawm glimepiride ntawm cov hlab plawv KATP channel tsis muaj zog dua li ntawm Glibornuride, gliclazide, thiab glipizide. Yog li ntawd, qhov tsis zoo ntawm cov hlab plawv cov tshuaj tiv thaiv ntawm cov khoom no yog tsawg dua li cov khoom ntawm peb cov khoom saum toj no.

Muaj ntau txoj kev xa khoom rau koj xaiv

Peb lub zog:

Peb lub tuam txhab tau dhau los ntawm FDA thiab ISO19001 kev tswj hwm qhov system ntawv pov thawj. Thiab peb muaj kev koom tes nrog kev cog lus nrog ntau lub Hoobkas thiab cov chaw soj nstuam hauv Suav teb, Yog li, peb lub tuam txhab tsis tuaj yeem muab cov khoom lag luam hypoglycemic nkaus xwb, xws liGlimepiride hmoovthiab glibenclamide hmoov. Peb tseem tuaj yeem muab lwm cov khoom lag luam tsis zoo, xws li Glibornuride, gliclazide, thiab glipizide, thiab peb tuaj yeem txhawb kev sib txuas ntawm qee cov khoom lag luam tsis txaus, xws li tolbutamide, CHLORPROPAMIDE thiab lwm yam.

Peb tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev thauj mus los, tab sis kuj txhawb ntau txoj kev them nyiaj, txawm tias koj siv nyiaj US, euros, Australian las, lossis cov nyiaj hauv zos los ntawm Singapore, Malaysia, Thaib, thiab lwm yam. Peb kuj tuaj yeem txhawb cov txiaj ntsig hauv zos hauv cov cheeb tsam thiab cov tebchaws no. Tsis tas li ntawd, peb kuj txhawb nqa cov npav hauv txhab nyiaj (credit cards, thiab lwm yam) rau kev them nyiaj.

Tsis lees paub: Cov ntaub ntawv luam tawm ntawm lub vev xaib no los ntawm Is Taws Nem, tsis tau txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm cov ntsiab lus. Thov ua tib zoo saib kom paub qhov txawv. Tsis tas li ntawd, cov khoom muab los ntawm peb lub tuam txhab tsuas yog siv rau kev tshawb fawb tshawb fawb. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.

Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais, thov hu rau peb los ntawmEmail :sales6@faithfulbio.com  . Peb pab neeg tau cog lus los ua kom tiav kev txaus siab ntawm cov neeg siv khoom.

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