Fosaprepitant hmoovyog ib tug neurokinin -1 receptor antagonist tsim rau kev tiv thaiv ntawm chemotherapy-induced xeev siab thiab ntuav (CINV). Cov kev tshawb fawb soj ntsuam tau pom tias cov khoom no muaj ib tug siab affinity rau tib neeg, tab sis ib tug tsawg affinity rau serotonin, dopamine, thiab corticosteroid receptors.
| Cov mis mos molecular |
|
|
|
Yam |
Txuj |
Kuaj cov txiaj ntsig |
|
Qhov tshwm sim |
Dawb crystalline hmoov |
Ua raws |
|
Daim qhia npe |
RT yog tib yam nrog cov qauv qauv hauv HPLC system |
Ua raws |
|
PH |
4.5 ~ 7.0 |
5.89 |
|
Melting point |
153 degree ~ 158 degree |
155 degree |
|
Optical kev sib hloov |
{{0 {}} degree ~ -20 degree |
18 DEGREE |
|
Poob rau ziab |
Tsawg dua los yog sib npaug rau 0. 50% |
0.13% |
|
Hnyav hlau |
Tsawg dua los yog sib npaug rau 0. 002% |
0.001% |
|
Dej (Kf) |
Tsawg dua los yog sib npaug rau 0. 5% |
0.3% |
|
Sulfated tshauv |
Tsawg dua lossis sib npaug rau 0.1% |
0.1% |
|
Cov ntsiab lus fluorin |
Ntau dua lossis sib npaug li 4.8% |
5.1% |
|
Tus kab chlorides |
Tsawg dua los yog sib npaug rau 0. 02% |
0.02% |
|
Cov khoom muaj feem xyuam |
Tus kheej impurity: Tsawg dua lossis sib npaug rau 0.5% Tag nrho cov impurity: tsawg dua los yog sib npaug rau 2. 0% |
0.1% 1.8% |
|
Assisy (anhydrous) |
Ntau dua los yog sib npaug rau 98% |
98.89% |
| Xaus: |
Ua raws li kev lag luam specification. |
Lub hauv paus ntsiab lus pharmacological ntawm cov khoom no yog dab tsi?
Peb paub tias cov khoom P yog ib hom tachykinin (neurokinin), uas yog nyob rau hauv nruab nrab thiab peripheral paj hlwb neurons. Nws muaj feem xyuam rau ntau lub zog, xws li ntuav, kev nyuaj siab, mob inflammatory thiab o ntawm lwm yam kab mob. Qhov kev txiav txim ntawm cov tshuaj P yog kho los ntawm NK-1 receptor, uas yog G protein receptor thiab txuas nrog phosphoinositide teeb liab txoj kev. Yog tias peb tuaj yeem xaiv kev tiv thaiv kev sib xyaw ntawm cov tshuaj P thiab NK-1 receptor nyob rau hauv lub hauv paus paj hlwb, peb tuaj yeem ua tiav qhov kev tiv thaiv ntawm cov kab mob saum toj no.
ntshiab Fosaprepitanttuaj yeem cuam tshuam qhov ntuav ntuav thiab ntuav los ntawm cisplatin hauv 72 teev ntawm kev siv hauv tus qauv tsiaj tus kheej. Lub caij no, cov khoom no tuaj yeem txhim kho nws cov nyhuv antiemetic los ntawm kev sib txuas nrog dexamethasone lossis 5-HT receptors, lossis nrog cov receptor blockerondansetronCov. Hauv kev sim simulation ntawm kev ua haujlwm molecular, peb pom tiasFosaprepitant hmoovFeem ntau butters kev txiav txim ntawm cov tshuaj p los ntawm binding to nk -1 Cov receptors (tsuas yog tam sim no hauv nruab nrab ntawm cov leeg ntshav thiab nws lub periphery). Tab sis lub affinity rau nk -2 thiab nk -3 receptors yog tsawg heev.
Muaj ntau txoj kev xa khoom rau koj xaiv
|
Tsheb Thauj Mus Los |
Shipping Txoj Kev |
Cargo Qhov hnyav |
Qhov zoo |
|
3-7 hnub |
DHL, Lub teb chaws Yelemees DHL, Lub teb chaws Yelemees DPD, |
Haum rau hauv qab 50kg. |
Peb muaj cov chaw khaws khoom hauv Tebchaws Yelemees thiab California, Asmeskas, |
|
7-15 hnub |
Los ntawm huab cua |
Haum rau ntau tshaj 50kg. |
|
|
15-60 hnub |
Los ntawm Hiav Txwv |
Haum rau ntau tshaj 500kg. |
Peb ua tau zoo:
Peb lub tuam txhab tau dhau FDA thiab ISO19001 kev tswj hwm kev tswj hwm kev ua haujlwm zoo. Thiab peb muaj kev pom zoo sab hauv kev sib koom tes nrog ntau yam khoom lag luam thiab chaw kuaj xyuas hauv Suav teb, peb lub tuam txhab tuaj yeem muabFosaprepitant hmoovtus lwm yam. ntawm ib tug nqi ntau dua. Yog tias koj txaus siab, thov tso cov lus.
Peb tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev thauj mus los, tab sis kuj txhawb ntau txoj kev them nyiaj, txawm tias koj siv nyiaj US, euros, Australian las, lossis cov nyiaj hauv zos los ntawm Singapore, Malaysia, Thaib, thiab lwm yam. Peb kuj tuaj yeem txhawb cov txiaj ntsig hauv zos hauv cov cheeb tsam thiab cov tebchaws no. Tsis tas li ntawd, peb kuj txhawb nqa cov npav hauv txhab nyiaj (credit cards, thiab lwm yam) rau kev them nyiaj.
Tsis lees paub: Cov ntaub ntawv luam tawm ntawm lub vev xaib no los ntawm Is Taws Nem, tsis tau txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm cov ntsiab lus. Thov ua tib zoo saib kom paub qhov txawv. Tsis tas li ntawd, cov khoom muab los ntawm peb lub tuam txhab tsuas yog siv rau kev tshawb fawb tshawb fawb. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.
Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais, thov hu rau peb los ntawmEmail :sales6@faithfulbio.com . Peb pab neeg tau cog lus los ua kom tiav kev txaus siab ntawm cov neeg siv khoom.
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