Gemcitabine hydrochloride hmoovyog ib hom tshiab hluavtaws ntawm ob fluoro nucleoside antitumor tshuaj. Nws tau pom zoo xyoo 1995 hauv South Africa, Sweden, Holland, Australia, thiab lwm lub tebchaws. Xyoo 1996, US Food and Drug Administration tau pom zoo thawj kab kev kho mob rau cov qog nqaij hlav qog nqaij hlav tsis me me thiab mob qog nqaij hlav pancreatic. Nyob rau hauv xyoo tas los no, cov tshuaj zoo rau kev kho mob ntawm cov qog nqaij hlav qog nqaij hlav tsis me me (NSCLC) tau qhia txog kev nce siab, xws li gemcitabine, paclitaxel, docetaxel, yog vinblastine, thiab lwm yam. Piv nrog rau cov tshuaj chemotherapy, lawv muaj qhov zoo ntawm cov nyhuv curative siab thiab tsawg toxicity.
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| Gemcitabine hydrochloride hmoov | Gemcitabine HCL Molecular formula |
Dab tsi yog cov txheej txheem thiab qhov zoo ntawm gemcitabine hydrochloride?
Gemcitabine hydrochloride hmoovyog ib tiam tshiab ntawm cov tshuaj antimetabolic. Nws yog ib hom tshuaj tiv thaiv kab mob ntawm tes. Nws feem ntau ua rau S-phase hlwb hauv DNA synthesis theem. Raws li qee qhov xwm txheej, nws tseem tuaj yeem tiv thaiv kev loj hlob ntawm G1 theem mus rau theem S. Nws muaj zog tiv thaiv kab mob tiv thaiv kab mob qog noj ntshav uas tsis yog me me (NSCLC). Cov kev tshawb fawb txawv teb chaws tau pom tias qhov ua tau zoo ntawm gemcitabine hydrochloride ib leeg hauv kev kho NSCLC yog 18% ~ 35%. Qhov txiaj ntsig zoo ntawm kev sib xyaw cisplatin hauv kev kho mob ntawm cov qog nqaij hlav tsis me me (NSCLC) yog 41.7%. Qhov txiaj ntsig zoo ntawm carboplatin ntawm NSCLC qib siab yog 16%, uas zoo ib yam li cisplatin, tab sis cov tshuaj toxicity tsawg, tshwj xeeb tshaj yog nyob rau hauv plab hnyuv cov tshuaj tiv thaiv, pob txha pob txha, thiab raum thiab peripheral paj hlwb. Ua ke nrog carboplatin, nws muaj kev sib koom ua ke thiab ntxiv cov nyhuv thiab tuaj yeem tsim cov nyhuv curative ntau dua.
Dab tsi yog cov teebmeem ntawm gemcitabine hydrochloride?
Gemcitabine hydrochloride hmoovmuaj kev ua kom pom tseeb cytotoxic ntawm cov kab mob nas kab mob, thiab nws cov haujlwm tiv thaiv kab mob cuam tshuam nrog rau hom kev tswj hwm. Piv txwv li, kev tswj hwm txhua hnub tuaj yeem ua rau cov tsiaj tuag, tab sis nws cov kev tiv thaiv kab mob tsawg heev. Txawm li cas los xij, thaum muab cov tshuaj ib zaug txhua 3 ~ 4 hnub, qhov koob tshuaj ntawm cov tshuaj tsis ua rau tuag taus, uas muaj cov tshuaj tiv thaiv kab mob zoo rau ntau hom qog.
Cov kev mob tshwm sim ntawm cov khoom no muaj xws li kev tiv thaiv pob txha pob txha, anemia, leukopenia, thiab thrombocytopenia. Kwv yees li 66% ntawm cov neeg mob muaj cov kab mob siab transaminase abnormalities, feem ntau mob me me thiab tsis-progressive puas. Kwv yees li 33% ntawm cov neeg mob tsim xeev siab thiab ntuav. Kwv yees li ntawm 50% ntawm cov neeg mob muaj cov proteinuria me me thiab hematuria, thiab qee qhov xwm txheej tau piav qhia lub raum tsis ua haujlwm. Kwv yees li 25% ntawm cov neeg mob tau tsim cov pob khaus tawv nqaij thiab 10% ntawm cov neeg mob tsim khaus. Tsawg dua 1% ntawm cov neeg mob yuav muaj bronchospasm, thiab lwm yam.
Puas yog kev ua haujlwm lom neeg ntawm cov khoom no puas muaj lwm yam cuam tshuam rau lub cev?
Raws li ib tug prodrug, cov khoom no yog ib tug zoo substrate rau deoxythymidine kinase phosphorylation hauv hlwb. Raws li kev txiav txim ntawm enzymes, nws tuaj yeem hloov mus rau hauv cov metabolites hauv qab no: Gemcitabine phosphate (DFDCMP), gemcitabine diphosphate (DFDCDP), thiab gemcitabine triphosphate (tsis xws luag), ntawm ob qhov tom kawg yog cov khoom lag luam. Tib lub sijhawm, gemcitabine HCl (ly188011), raws li DNA synthesis inhibitor, ua rau PANC1, miapaca2, bxpc3, thiab capan2 hlwb nrog IC50 ntawm 50 nm, 40 nm, 18 nm, thiab 12 nm, raws li. Clinically, cov kev kho mob tseem ceeb rau cov khoom no yog qib siab lossis metastatic pancreatic mob qog noj ntshav thiab hauv zos qib siab lossis metastatic uas tsis yog-me me ntawm lub ntsws qog nqaij hlav, mob qog noj ntshav siab tsis me me, mob qog noj ntshav tsis me me, mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav. , thiab lwm yam qog nqaij hlav.
Tsis lees paub: tshwj tsis yog tias tau teev tseg, tsab xov xwm kev paub luam tawm los ntawm lub vev xaib no los ntawm Is Taws Nem thiab feem ntau yog siv los txhawb kev sib pauv kev kawm thiab kev kawm. Nws tsis txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Thov ua tib zoo tshuaj xyuas nws. Yog tias koj xav tias muaj kev ua txhaum cai hauv tsab xov xwm no, thov hu rau tus thawj tswj hwm. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv cov ntaub ntawv thiab kev pabcuam ntawm lub vev xaib no.
Nco tseg: Tag nrho cov tebchaw muaj kev pheej hmoo. Thov nrog koj tus kws qhia ntawv, kws kho mob, lossis lwm tus kws tshawb fawb ua ntej siv. Cov khoom no tsis yog siv los kuaj xyuas, tiv thaiv lossis kho cov kab mob, tab sis tsuas yog siv rau kev tshawb fawb tshawb fawb. Lub tuam txhab tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.
Yog tias koj xav tau kev pab, thov hu rau peb
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