Linagliptin API hmoov CAS 668270-12-0

Linagliptin API hmoov CAS 668270-12-0yog DPP-IV inhibitor. DPP-IV yog ib qho incretin hormone uas khi rau cov protein thiab muaj nyob rau hauv ntau cov ntaub so ntswg, xws li ob lub raum, siab, txhuam ciam teb ntawm cov hnyuv me, cov kab mob pancreatic, lymphocytes, thiab endothelial hlwb. Cov enzyme no inactivates GLP-1 los ntawm hydrolyzing N-terminal alanine residue ntawm txoj hauj lwm 2. Yog li ntawd, inhibiting cov enzyme no nce GLP-1 concentration, stimulating insulin ntau lawm los ntawm pancreatic islet hlwb thaum tib lub sij hawm txo glucagon concentration, yog li exerting andiabetic nyhuv. Linagliptin inhibits DPP-IV los ntawm nruj ligand / receptor binding, sib tw nrog substrates rau khi qhov chaw. Nws yog ib qho kev xaiv, sib tw, thiab thim rov qab DPP-IV inhibitor.

Linagliptin (BI-1356) yog ib qho muaj zog thiab xaiv DPP-4 inhibitor nrog IC50 ntawm 1 nM. Nws cov kev xaiv rau DPP-4 yog ntau dua 10,000 npaug ntau dua li lwm cov dipeptidyl peptidases xws li DPP-2, DPP-8, thiab DPP9. Linagliptin activates glomerular autophagy hauv hom 2 mob ntshav qab zib hom 2. DPP4 mediates ferroptosis hauv TP53-tsis muaj CRC hlwb.