Methylglucamine CAS 6284-40-8

Meglumine hmoovyog cov hmoov dawb crystalline uas yog soluble hauv dej, me ntsis soluble hauv ethanol, thiab yuav luag insoluble hauv chloroform. Me ntsis qab zib nrog rau qab ntsev thiab astringent saj, Ntshiab meglumine yog qhov sib npaug ion dav siv los txhim kho cov tshuaj solubility. Thiab qhov tsim nyog sib npaug ions yog qhov tseem ceeb tshwj xeeb rau kev txhim kho cov solubility thiab bioavailability ntawm cov khoom siv raw khoom.

Yuav ua li cas thiaj tsim tau meglumine?

Muaj meglumine yog tau los ntawm condensation ntawm qabzib thiab monomethylamine thiab tom qab ntawd catalytic hydrogenation.

Kauj Ruam 1: ntxiv anhydrous ethanol thiab cov qabzib qhuav rau hauv lub lauj kaub cov tshuaj tiv thaiv, qhia cov roj monomethylamine qhuav ntawm 50 degree, hnov ​​​​mob rau 1.5-2h, thiab tom qab ntawd cov tshuaj maj mam meej, thiab khaws cia ntawm 50 degree rau 2h mus rau muab Glucose dimethylamine kua.
Kauj Ruam 2: Cov tshuaj Glucose dimethylamine tau muab ntxiv rau hauv autoclave, pressurized rau 2.5MPa los ntawm kev qhia hydrogen nyob rau hauv lub xub ntiag ntawm Raney nickel, thiab nplawm ntawm 80-85 degree rau 1-2 teev. Tom qab ntawd tso tawm tom qab txias thiab siab nyem, txias thiab crystallizing cov txheej txheej meglumine ethanol, thiab lim kom tau cov khoom meglumine crude.
Kauj ruam 3: lub crude meglumine yog refined thiab ces purified kom tau cov khoom tiav.

Feem ntau, peb siv meglumine li cas?

Meglumine yog cov cawv qab zib tau los ntawm cov piam thaj uas muaj cov amino pawg hloov pauv. Yog li ntawd, nws yog feem ntau siv raws li ib tug excipient ntawm cov tshuaj, tshwj xeeb tshaj yog nws muaj peev xwm tsim ntsev nrog ib co tshuaj los ua kom lub solubility ntawm cov tshuaj, thiab nws yog ib qho zoo heev latent hnyav nyob rau hauv cov tshuaj. Tsis tas li ntawd, cov khoom no kuj tseem siv tau ua cosolvent thiab surfactant ntawm tus neeg sawv cev sib txawv. thiab ua ke nrog iodinated tebchaw hauv kev sib piv xov xwm xws li diatrizoate meglumine, iothalamate meglumine, thiab iodipamide meglumine.

Daim ntawv thov tshiab ntawm meglumine hauv tshuaj yog dab tsi?

Meglumine muaj cov permeability zoo sib xws thiab ionic radius rau sodium, uas tuaj yeem txhim kho cov tshuaj solubility thiab bioavailability, thiab tsis nkag mus rau cell membrane. Nws feem ntau yog siv los hloov cov sodium hauv kev kho mob, xws li Co-solvent ntawm tus neeg sawv cev sib txawv, surfactants, cosolvents, tshuaj ntsuam xyuas thiab lwm yam. Tab sis qhov tseeb, meglumine muaj ntau yam kev siv thiab tsim nyog rau txhua yam tsis muaj zog acidic tshuaj nrog PKa tus nqi ntawm 2 thiab 7. Tsis tas li ntawd, meglumine tuaj yeem ua rau kom muaj kev cog lus ntawm myocardium, dilate peripheral cov hlab ntsha, thiab yog li txo cov hlab plawv. Nws tuaj yeem siv rau kev tiv thaiv thiab kho kab mob plawv, cardiomyopathy, myocarditis, mob plawv / mob plawv tsis ua haujlwm, mob sinus syndrome thiab lwm yam kab mob hauv tsev kho mob.

Muaj ntau txoj kev xa khoom rau koj xaiv

Peb lub zog:

Peb lub tuam txhab tau dhau los ntawm FDA thiab ISO19001 kev tswj hwm qhov system ntawv pov thawj. Thiab peb muaj kev koom tes nrog kev cog lus nrog ntau lub Hoobkas thiab chaw kuaj hauv Suav teb, Peb lub tuam txhab tuaj yeem muabMeglumine,diatrizoate meglumine, thiab lwm yam. ntawm tus nqi zoo dua. Yog tias koj txaus siab, thov sau ib tsab ntawv.

Peb tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev thauj mus los, tab sis kuj txhawb ntau txoj hauv kev them nyiaj, txawm tias koj siv nyiaj US, euros, Australian las, lossis cov nyiaj hauv zos los ntawm Singapore, Malaysia, Thaib, thiab lwm yam. Peb kuj tuaj yeem txhawb cov txiaj ntsig hauv zos hauv cov cheeb tsam thiab cov tebchaws no. Tsis tas li ntawd, peb kuj txhawb nqa cov npav hauv txhab nyiaj (credit cards, thiab lwm yam) rau kev them nyiaj.

Tsis lees paub: Cov ntaub ntawv luam tawm ntawm lub vev xaib no los ntawm Is Taws Nem, tsis tau txhais hais tias lub vev xaib no pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm cov ntsiab lus. Thov ua tib zoo saib kom paub qhov txawv. Tsis tas li ntawd, cov khoom muab los ntawm peb lub tuam txhab tsuas yog siv rau kev tshawb fawb tshawb fawb. Peb tsis muaj lub luag haujlwm rau qhov tshwm sim ntawm kev siv tsis raug.

Yog tias koj txaus siab rau peb cov khoom, lossis muaj cov lus qhia tseem ceeb ntawm peb cov khoom lossis tsis txaus siab rau cov khoom tau txais, thov hu rau peb los ntawmEmail :sales6@faithfulbio.com  . Peb pab neeg tau cog lus los ua kom tiav kev txaus siab ntawm cov neeg siv khoom.

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